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Drug effects and Aspirin

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by

Harvey Buckle

on 7 September 2017

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Transcript of Drug effects and Aspirin

Drug effects and Aspirin
Effect of drugs
Watch Mr Harvey
Understand
Mild analgesics function by intercepting the pain stimulus at the source, often by interfering with the production of substances that cause pain, swelling or fever. • Aspirin is prepared from salicylic acid. • Aspirin can be used as an anticoagulant, in prevention of the recurrence of heart attacks and strokes and as a prophylactic.
Under discussion
The effect of drugs
The effect and synthesis os Aspirin
Applications
Description of the use of salicylic acid and its derivatives as mild analgesics.
• Explanation of the synthesis of aspirin from salicylic acid, including yield, purity
by recrystallization and characterization using IR and melting point.
• Discussion of the synergistic effects of aspirin with alcohol.
• Discussion of how the aspirin can be chemically modified into a salt to increase
its aqueous solubility and how this facilitates its bioavailability.
Drug packets
Get into pairs and prescribe
Details
Salycyclic acid
2 OH Benzoic acid
Ester form as it make stomach, mouth and thraot bleed
Prostoglandins synthase
carrying message to brain
Prevents sweling - arthritis e.g
Strokes - thins blood
Too much - acidosis fatal
Synergistic effects
Parcetamol e.g less probematic but high does kidney and liver damage

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