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Kyra Boldrighini

on 27 May 2014

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Looking For New Inhibitants
Ten mice were infected with MRSA and over time the growth of the MRSA was tracked. Then fluid samples were taken from the infected mice and collected by counting the cells of MRSA. The cells were measured by taking one gram of the fluid and spread it over plates. Then allowed them to grow for 24 hours measuring the colonies in a logarithmic (log) scale.
Average effects of treatment on MRSA after 24hrs
Penicillin Resistance
Penicillin prevents cell wall synthesis with the B-lactam ring. The B-lactam ring stops PBP (penicillin-binding protein) from creating an amino acid bridge connecting the walls, making the cell resistant to osmotic pressure. B-lactam blocks the active site for the amino acid bridge. Without the bridge, the cell wall does not form properly
Comparing Inhibitation in MRSA & S. aureus
This case study's focus is on antibiotic resistance in
Staphylococcus aureus
, or MRSA. MRSA is resistant to most of the penicillin derivatives. Most cases of MRSA are hospital-acquired but community-acquired MRSA is becoming more common. If MRSA is detected then you must switch the treatment to vancomycin, a completely different kind of antibiotic.
Can We Ever Win?

Photos of MRSA
Average & Standard Deviation
In this experiment they tested the effects of the FtsZ inhibitor and imipenem. This showed that the FtsZ inhibitor and Imipenem alone worked ok, but together they worked really well
Restoring Susceptibility
Background Information
MRSA Bacteria http://www.bpac.org.nz/BT/2013/June/infected-wounds.aspx
MRSA Infection http://www.surviveoutdoors.com/emergency/mrsa.asp
Photos of MRSA Infections http://www.cdc.gov/mrsa/community/photos/
MRSA vs. Spider Bite http://img.webmd.com/dtmcms/live/webmd/consumer_assets/site_images/articles/health_tools/MRSA_revised_slideshow/webmd_rm_photo_of_spiderbite_and_mrsa.jpg
Overtime the cells have mutated and has become resistant to the B-lactam ring.
MRSA stands for methicillin-resistant S. aureus.
Penicillin, methicillin, and cephalothin have no effect on MRSA because they are all related to methicillin.
Vancomycin is a completely different kind of antibiotic that MRSA is not resistant to.
Laboratory MRSA mouse http://www.niaid.nih.gov/SiteCollectionImages/topics/antimicrobialresistance/staphGenes.jpg
Real World Connection
Even though B-lactam antibiotics are still heavly used, resistance is a big problem. With the dicovery of new inhibitants like the FtsZ inhibator we can create new antibiotics to aid in the fight against bacteria.
Works Cited
Leonard, Maureen. " Antibiotic Resistance: Can We Ever Win?” Case Study 1 (2012): 11. Print.
"MRSA." Niaid. N.p., n.d. Web. 26 May 2014. <http://www.niaid.nih.gov/SiteCollectionImages/topics/antimicrobialresistance/staphGenes.jpg>.

"MRSA Infection (False Spider Bite)." MRSA Infection (False Spider Bite). N.p., n.d. Web. 26 May 2014. <http://www.surviveoutdoors.com/emergency/mrsa.asp>.

"MRSA Photos." Centers for Disease Control and Prevention. Centers for Disease Control and Prevention, 10 Sept. 2013. Web. 26 May 2014. <http://www.cdc.gov/mrsa/community/photos/>.

"Microbiological assessment of infected wounds: when to take a swab and how to interpret the results." Microbiological assessment of infected wounds. N.p., n.d. Web. 26 May 2014. <http://www.bpac.org.nz/BT/2013/June/infected-wounds.aspx>.

"Spiderbite vs. MRSA." Web MD. N.p., n.d. Web. 26 May 2014. <http://img.webmd.com/dtmcms/live/webmd/consumer_assets/site_images/articles/health_tools/MRSA_revised_slideshow/webmd_rm_photo_of_spiderbite_and_mrsa.jpg>.
by Vanessa Rios, Katie Staples, & Kyra Boldrighini
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