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Preparation and standardization of sodium thiosulfate
Transcript of Preparation and standardization of sodium thiosulfate
Question and Answers
antidote of cyanide poisoning
treatment of calciphylaxis in haemodialysis patients
Dissolve sodium thiosulfate and sodium carbonate in 1000 mL of recently boiled and cooled water.
Weigh accurately the Potassium dichromate (
previously pulverized and dried at 120 C for 4 hours
) and dissolved in 1000 mL of water in a glass stoppered 500 mL flask.
Swirl to dissolve the sample, remove the stopper and add KI, Sodium bicarbonate and hydrochloric acid stopper the flask.
Swirl to mix, and allow to stand in dark for 10 minutes.
Rinse the stopper and the inner walls of the flask with water.
Titrate the liberated iodine with sodium thiosulfate until the solution is only faintly
Add the starch TS and continue the titration to the discharge of
Why should the water use in dissolving sodium thiosulfate is recently boiled?
FOR THE PURPOSE OF STERILIZATION
IT COMPELS CARBON DIOXIDE
What is the use of adding sodium carbonate to the sodium thiosulfate solution?
USE AS PRESERVATIVE TO PREVENT ACID-CATALYZED HYDROLYSIS
Write the chemical equation of sodium thiosulfate and potassium dichromate?
What is responsible for the greenish color of the solution at the endpoint of the titration?
Aside from using potassium dichromate, how is sodium thiosulfate standardize?
SODIUM THIOSULFATE CAN BE STANDARDIZED AGAINST PURE IODINE DISSOLVED IN KI OR AGAINST IODINE SET FREE FROM AN ACIDIFIED SOLUTION OF KI BY STANDARD SOLUTION OF POTASSIUM PERMANGANATE OR VARIOUS PRIMARY STANDARD OXIDIZING AGENTS SUCH AS POTASSIUM IODATE.
26 g Sodium thiosulfate
200 mg Sodium carbonate
210 mg Potassium dichromate
5 mL hydrochloric acid
2 g Sodium bicarbonate
3 g Potassium iodide
Jenkin's Quantitative Pharmaceutical Chemistry by Digangi and Knevel
: sodium thiosulfate
K2Cr2O7 + 6KI +14HCl 3I2 + 2CrCl3 +8KCl +7H2O