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Acquired Aplastic Anemia

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Mohamed khaled

on 29 September 2013

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Transcript of Acquired Aplastic Anemia

Loss of weight
((Thiamphenicol for two weeks!))
on clinical examination:
Aplastic anemia
The story of Ehab
Sch. hematobium
Anclystoma duod.
1. Prevalence
2. Patho-physiology

Anemia: Malaise, Breathlessness, weight loss, Tachycardia

Sch. hematobium: Hepatosplenomegaly, Hypersplenism, calcium stones, hematuria, fever, malaise, anemia(hemorrhagic, microcytic, hemolytic)

Anclystoma: blood in the stool, fever, anemia(microcytic, hemorrhagic)

Granulocytopenia: fever
Aplastic anemia
Bone marrow biopsy to confirm
RBCs shows:

Anisocytosis: variation in size of cells

Poikilocytosis: abnormal RBCs
WBC shows:
moderate leucopenia (neutropenia

Complete Blood Picture
Pancytopenia with
fatty bone marrow
3. Etiology:
- Direct toxicity (Radiation, Chemotherapy, Benzene, Drugs)
-Immune mediated (Autoimmune, Pregnancy, drugs, Viral infection)
drug induced
benzene induced
4. TTT (management/ cure/ genetic counseling)
5. Possible TTT
4. complications
Full transcript