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phenelzine

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by

arwa abouelenain

on 14 April 2011

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Transcript of phenelzine

Also called: Clinical depression, Dysthymic disorder, Major depressive disorder, Unipolar depression.
Sadness Change
In Weight death or
suicide Feelings of worthlessness Energy loss Symptoms Hydrazine GABA Anxiolytic
Effect Initial Dose Early phase treatment Maintenance
dose Absorption Tmax
= 43 minutes =19.8 ng/mL Its effect lasts for several weeks Metabolism 73% - 96 hours phenylacetic acid and parahydroxyphenylacetic Elimination half-life elimination
= 11.6 hrs. Treat symptoms of depression:
Sadness
guilt
anxiety disorder
insomnia
thoughts of death or suicide hypertension
crisis Serotonin
syndrome vitamin B6 Barbiturates Clomipramine
(Anafranil) Insulin agitation confusion difficulty
breathing fainting
spells
headache fever &
increased
sweating Activation
of Mania or
Hypomania Orthostatic
Hypotension
Seizures Nervous
System
Effects Endocrine
and Metabolic
Effects Withdrawal
Of Therapy Cmax http://www.nlm.nih.gov/medlineplus/depression.html

http://media.pfizer.com/files/products/uspi_nardil.pdf

http://www.minddisorders.com/Ob-Ps/Phenelzine.html

http://www.drugs.com/monograph/phenelzine-sulfate.html

Textbook: Psychologists' psychotropic drug reference (pages 490, 491, 493)

Instant pharmacology book (page 279) Treat eating disorders (Bulimia nervosa),
Changes in appetite. Group Number 5 Group Co-ordinatior Dr. Amr Mahrous Trade name:
Nardil®
Generic name:
phenelzine / phenelzine sulfate
Pharmacological class:
hydrazine monoamine-oxidase inhibitor
Mode of action:
Anti-depressant
Full transcript