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How Antibiotics Work and the Basis of Antibiotic Resistance

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Mary Frances Ypma-Wong

on 13 January 2016

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Transcript of How Antibiotics Work and the Basis of Antibiotic Resistance

Define Antibiotic and Semisynthetic Antibiotic

Antibiotic- An antimicrobial agent, usually produced naturally by a bacterium or fungus.

Semisynthetic Antibiotic- A natural antibiotic that has been chemically modified in the laboratory to enhance its stability
Learning Objectives

1. Define antibiotic and semisynthetic antibiotic.

2. Compare bactericidal versus bacteriostatic

3. Identify five modes of action of antimicrobial drugs.

4. Describe how resistance can develop and spread.

5. Detail five mechanisms of antibiotic resistance.

6. List four ways to minimize the development of antibiotic resistance.
3.How Antibiotics Work
5.Mechanisms of Antibiotic Resistance
4.Development of Resistance and the Spread of Resistance
Then, mutations spread between bacterial species by:

1) cell division

2) transduction

3) conjugation

4) transformation

FIVE Mechanisms of Antibiotic Resistance
1. Prevent entry/uptake of antibiotic/drug
2. Enzymatic destruction/inactivation of drug
3. Alteration of drug's target site
4. Rapid efflux of the drug
5. Bypass metabolic pathway
#5 Bypass metabolic pathway –not shown
Then, resistance strains spread among people and animals
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