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Epigenetics: The Effect of your Hormones on Gene Expression
Transcript of Epigenetics: The Effect of your Hormones on Gene Expression
Other Mental Illnesses
Unravel the chromatin
Changes in gene exposure
Passed down parent to child
Behavioral Epigentics: Hormones as Epigenetic Mechanisms
Hormones as epigenetic signals has been one of the more recent advances in the study of epigenetics,focusing mostly on environmental stimuli.
Acute restraint stress
Epigenetics: The Effect of your Hormones and Stress on Gene Expression
16% of all people
Only 40% genetic
Major environmental factors
Increased Stress: Increased Depression
Long term consequences
Introduction to Epigentics
What is epigenetics?
Epigenetics is the "study of changes in organisms caused by modification of gene expression rather than the genetic code itself"
Mechanisms of Epigenetics
146 base pairs of DNA
4 types histone proteins (H2A, H2B, H3, and H4)--8 in total.
Linker Histone H1
Activation and control of the genome
Most recognized way of epigenetic modification
5' position of the Cytosine ring within Cpg dinucleotides
Cancer Studies (inappropriate methylation)
Variations in behavior
Sexual dimorphism in DNA methylation
ERα by DNA methylation in the cortex of males and females
Prevention of Brain Damage
Epigenetic Regulation of Peptide Hormones
Non endocrine Tissues
Encoded by one or two genes
Cascade--Second Messengers- CAMP
Fewer methyl groups
Long lasting change
Prepare for future
“If you think of the stress system as preparing you for fight or flight, you might imagine that these epigenetic changes might prepare you to fight harder or flee faster the next time you encounter something stressful.”
Alzheimer's disease--altered methylation patterns
DNA methylation microarrays
Therapy--Cancer, Alzheimers, Fragile X Syndrome
Chronic stress is no joke!
Champagne, Frances A., and Emilie F. Rissman. "Behavioral Epigenetics: A New Frontier in the Study of
Hormones and Behavior." Hormones and Behavior 59.3 (2011): 277-78. 2011. Web. 3 June 2015.
"Chronic Stress May Cause Long-Lasting Epigenetic Changes." Johns Hopkins Medicine. 10 Sept. 2010.
Web. 3 June 2015.
Crews, David. "Epigenetics, Brain, Behavior, and the Environment." Hormones.gr. 18 Dec. 2009. Web. 03
"Epigenetic Modifications Regulate Gene Expression." Epigenetic Modifications Regulate Gene
Expression. Web. 03 June 2015.
Fowden, Abigail L., and Alison J. Forhead. "Hormones as Epigenetic Signals in Developmental
Programming." Wiley Online Library. John Wiley and Sons, Inc., 15 Apr. 2009. Web. 03 June 2015.
Stankiewicz, Adrian M., Artur H. Swiergiel, and Pawel Lisowski. "Epigenetics of Stress Adaptations in
the Brain." ScienceDirect. Sept. 2013. Web. 03 June 2015.
Zhang, Xiang, and Shuk-Mei Ho. "Epigenetics Meets Endocrinology." Journal of Endocrinology. Society
for Endocrinology, 24 Nov. 2010. Web. 3 June 2015.
"Brain Power." Flickr. Yahoo! Web. 03 June 2015.
"CGS : What Neuro-revolution? The Public Find Brain Science Irrelevant and Anxiety-Provoking." CGS :
What Neuro-revolution? The Public Find Brain Science Irrelevant and Anxiety-Provoking. Web. 03 June 2015.
"DNA." Mashable. Web. 03 June 2015.
"DNA Methylation and Hydroxymethylation." DNA Methylation and Hydroxymethylation. Web. 03 June
"Epigenetics and Chromatin Structure." Epigenetics and Chromatin Structure. Web. 03 June 2015.
"Findings from Quantitative Analysis of Chromatin Structure Challenge Classical Model of Static
Regularity." Findings from Quantitative Analysis of Chromatin Structure Challenge Classical Model of Static Regularity. Web. 03 June 2015.
"Jody's Fitness - BLOG - Stressed Out? Try a Little Exercise..." Jody's Fitness - BLOG - Stressed Out? Try a
Little Exercise...Web. 03 June 2015.
"Nature vs. Nurture series." My Bin of Thoughts. 15 July 2010. Web. 03 June 2015.
"Research - Nathaniel Martin's Research Page." Nathaniel Martins Research Page. Web. 03 June 2015.
"Why Too Much Stress Leads To Too Little - The Body Consultants." The Body Consultants. 02 June 2014.
Web. 03 June 2015.
William, Aarron Jacob. "What Is Epigenetics?" Vimeo. 2014. Web. 03 June 2015.