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Epigenetics: The Effect of your Hormones on Gene Expression
Transcript of Epigenetics: The Effect of your Hormones on Gene Expression
Other Mental Illnesses
Unravel the chromatin
Changes in gene exposure
Passed down parent to child
Behavioral Epigentics: Hormones as Epigenetic Mechanisms
Hormones as epigenetic signals has been one of the more recent advances in the study of epigenetics,focusing mostly on environmental stimuli.
Acute restraint stress
Epigenetics: The Effect of your Hormones and Stress on Gene Expression
16% of all people
Only 40% genetic
Major environmental factors
Increased Stress: Increased Depression
Long term consequences
Introduction to Epigentics
What is epigenetics?
Epigenetics is the "study of changes in organisms caused by modification of gene expression rather than the genetic code itself"
Mechanisms of Epigenetics
146 base pairs of DNA
4 types histone proteins (H2A, H2B, H3, and H4)--8 in total.
Linker Histone H1
Activation and control of the genome
Most recognized way of epigenetic modification
5' position of the Cytosine ring within Cpg dinucleotides
Cancer Studies (inappropriate methylation)
Variations in behavior
Sexual dimorphism in DNA methylation
ERα by DNA methylation in the cortex of males and females
Prevention of Brain Damage
Epigenetic Regulation of Peptide Hormones
Non endocrine Tissues
Encoded by one or two genes
Cascade--Second Messengers- CAMP
Fewer methyl groups
Long lasting change
Prepare for future
“If you think of the stress system as preparing you for fight or flight, you might imagine that these epigenetic changes might prepare you to fight harder or flee faster the next time you encounter something stressful.”
Alzheimer's disease--altered methylation patterns
DNA methylation microarrays
Therapy--Cancer, Alzheimers, Fragile X Syndrome
Chronic stress is no joke!
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