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Stem Cell Factor/ c-kit system: a molecular enhancer of metastasis from prostate cancer?

ISCOMS Oral Presentation
by

Alejandro Jiménez

on 14 December 2012

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Transcript of Stem Cell Factor/ c-kit system: a molecular enhancer of metastasis from prostate cancer?

Alejandro Jiménez-Sánchez

National University of Mexico Stem Cell Factor/c-Kit system:

a molecular enhancer of metastasis from prostate cancer? Prostate Cancer Statistics Hormone Therapy



Surgery



Radiation Therapy



Chemotherapy Prostate Cancer Stages Migration Clonogenicity Survival Metastatic
Cancer Cell
Behaviour Invasion Proliferation Metastasis The Project Cell lines c-Kit expression Migration Clonogenicity Mwm K562 DU145 PC3 HaCat RT-PCR Western Blot (cc) image by anemoneprojectors on Flickr Mwm K562 HaCat DU145 PC3 c-Kit 289pb c-Kit 145kDa GAPDH 37kDa 400 pb kDa 300 200 181.8 115.5 37.1 * * ** P<0.01
P<0.05 ** * ** ** P<0.01 ** P<0.05 * * * * * ** Proliferation * The Stem Cell Factor alone does not enhance the migration and clonogenicity abilities which are crucial steps for the whole metastatic behaviour.

However, Stem Cell Factor increases the proliferation rate of prostate cancer cell lines. Conclusions Stem Cell Factor/c-Kit system + Proliferation NO
Migration NO Clonogenicity (cc) photo by medhead on Flickr Jemal A. Global Cancer Statistics. (2011) National Cancer Institute
www.cancer.gov (2012) J. L. Spivak. The Anemia of Cancer: Death by Thousand Cuts. (2005) National Univeristy of Mexico

Leticia Rocha Zavaleta (supervisor)

Cecilia Aguilar (technical support)

Tzipe Govezensky (statistical support) Acknowledgments Proliferation


Survival


Migration
Full transcript