Send the link below via email or IMCopy
Present to your audienceStart remote presentation
- Invited audience members will follow you as you navigate and present
- People invited to a presentation do not need a Prezi account
- This link expires 10 minutes after you close the presentation
- A maximum of 30 users can follow your presentation
- Learn more about this feature in our knowledge base article
Do you really want to delete this prezi?
Neither you, nor the coeditors you shared it with will be able to recover it again.
Make your likes visible on Facebook?
You can change this under Settings & Account at any time.
Signals (ligands) bind with receptors
Transcript of Signals (ligands) bind with receptors
Agonists bind with receptors and have the same effect as the primary ligand, or might even increase activity more than the primary ligand
Antagonists bind with receptors and do not cause a cellular response. They "block" the receptor so the primary ligand cannot bind
Signals can act locally
or over distance
Local signals can be fat-soluble
or water soluble too, but there is no special terminology
Receptor is on the cell that
produced the signal
Signal binds with receptor on nearby cell.
Passes only through ISF
Long distance signals
Delivered by neurons
Travel through blood before binding with receptor
Hormones can be fat-soluble or water soluble
Steroids are fat-soluble
Non-steroids are water-
Estradiol (an estrogen)
Testosterone (an androgen)
Progesterone (a progestin)
Cortisol (a glucocorticoid)
Aldosterone (a mineralocorticoid)
Transport in blood
Steroids need a protein carrier because they are not water soluble. These are called steroid-binding globulins.
Location of the receptor
The receptor is located in the cytosol or nucleus. Steroids enter the cell by simple diffusion
Steroids activate gene expression
Diverse group of chemicals which include:
Catecholamines eg. epinephrine
Proteins eg. insulin, antidiuretic hormone
Transport in blood
Travel dissolved in blood - may need carrier protein for protection from enzymes
Location of Receptor
Receptors are located on the plasma membrane - hormone does NOT enter the cell
1. Activate enzyme
2. Activate 2nd messenger system
3. Open or close an ion channel