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The Nucleus Cell Campaign

Cathy Banh and Dylan Vanmali AP Biology Project

Dylan Vanmali

on 28 October 2013

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Transcript of The Nucleus Cell Campaign

Cathy Banh
Period 0/1

The Nucleus
AP Biology
Nucleus Is Best
Child With
Mitochondrial Disease
Dylan Vanmali
Damage to the cell
Phagocytosis: destruction of cells through digestive enzymes from the organelle
To function, lysosomes require a pH level of 4.5.
Acidity can cause damage to the cytosol killing host cell.

Lysosomal disorders are triggered when a particular enzyme exists in too small an amount or is missing altogether
Fabry disease - causes kidney and heart problems, pain and a skin rash
Gaucher disease - causes the spleen to enlarge, anemia and bone lesions if untreated
Hurler syndrome - causes deformities of the skeleton and facial features, enlargement of the spleen and liver, joint stiffness, clouding of the cornea, mental retardation and deafness
Niemann-Pick B disease - leads to enlargement of the spleen and liver, as well as lung disease
Pompe disease - an often fatal storage disease in which glycogen builds up in the liver, heart and muscle, especially during infancy (also known as acid maltase deficiency); weakens heart and muscles
Tay-Sachs disease - a lysosomal storage disease that occurs more commonly in people of Eastern European Ashkenazi descent and causes degeneration of the brain in infants
Mutation in a mitochondrial gene causes people to develop
High concentrations of blood cholesterol
Lower-than-normal concentrations of magnesium.

Dysfunction: cell damage then cell death

Has its own DNA and replicate its own DNA
Diseases caused by mutation in the mtDNA
mito- NOT YOUR - chondria
Diseases And Disorders
Kearns-Sayre syndrome (KSS).

Myoclonus epilepsy with ragged-red fibers (MERRF). MERFF is a mitochondrial encephalomyopathy in which there is an accumulation of diseased mitochondria)

Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS). MELAS is a progressive mitochondrial disease that involves multiple organ systems including the central nervous system, cardiac muscle, skeletal muscle, and gastrointestinal system
Baby With Healthy Nucleus
Nucleus Contains Specific Genetic Information That Makes Up You By Storing Our Chromosomes (DNA)
Nucleus Creates Many Other Organelles And Without Us They Wouldn't Exist
Nucleus Is The Brain Of The Entire System Creating, Processing, And Passing Information Throughout The Cell.
The Nucleus Membrane Bounds The Organelle Protecting The DNA Information.
The Nucleus Regulates The Amount Of Times The Genetic Information Goes Through Transcription (RNA Synthesis) And Translation (Protein Synthesis) By Regulating How Much Is Produced And What Genes Are Being Represented.
The Nuclear Envelope Has Pores To Control Movement Of Molecules Between The Nucleoplasm And The Cytoplasm
Controls Cellular Activities: Metabolism, Growth, And Reproduction By Regulating Gene Expression.
All Organelles Need Us To Tell Them What To Do And When To Do It
Most Organelles Need Us To Even Exist By Using Our Genetic Information To Tell Them What To Do, How To Do It, And When To Do It
We Manage And Build The Entire Cell
It has three main components: the nucleolus, the chromatin and the nuclear envelope
By Using The Cytoskeleton Which Our Genes Created, We Can Use Chemical Signals To Tell Our Network (The Cell) What To Do
Regulating Genes Expression, We Help Manage By Relaying and Messaging The Information Of The Cell Like A Computer Chip By Organizing and Creating Information
Knows What Is Happening Throughout The Cell Since Information Passes Through
Reason To Vote
Nucleolus Can't Even Campaign
Not An Organelle As Defined
Just a Part Of Us
Crumbled Up RNA, Ribosomes, and Proteins (No DNA)
Can't Exist Without Being Created From Our DNA
May Cause Errors In Translation
Our Nuclear Envelope Protects You From Being Destroyed By Protecting You From Invaders
No Such Thing As Rough ER Without The Nucleus's Nuclear Envelope
Rough ER Has No Use Cause A Cell Can Make Use Without One (Nucleus Has Pores And Molecules Can Transport Through The Cytoplasm)
The Ribosomes Attached To The Surface Are Created By Us
Our Ribosomes Are Not Only Attached To Rough ER But Are Located Throughout The Cell
Works Cited
BCSB. "Endoplasmic Reticulum (Rough and Smooth)." BSCB:The British Society for Cell Biology. BSCB, n.d. Web. 27 Oct. 2013. <http://www.bscb.org/?url=softcell/er>.

Bill Nye the Science Guy: Cells. Perf. Bill Nye. YouTube. Disney, 31 Mar. 2013. Web. 27 Oct. 2013. <

Davidson, Michael W. "Molecular Expressions Cell Biology: The Cell Nucleus." Molecular Expressions Cell Biology: The Cell Nucleus. Ed. Graphics & Web Programming Team with Optical Microscopy at the National High Magnetic Field Laboratory. Florida State University, 14 May 2005. Web. 27 Oct. 2013. <http://micro.magnet.fsu.edu/cells/nucleus/nucleus.html>.

"Drug Toxicity & Mitochondria." Mitochondrial Disease Action Committee. N.p., n.d. Web. 26 Oct. 2013.

Greatest Discoveries with Bill Nye. Perf. Bill Nye. YouTube. Disney, 09 Oct. 2008. Web. 27 Oct. 2013. <

"Hydrolase (class of Enzymes)." Encyclopedia Britannica Online. Encyclopedia Britannica, n.d. Web. 26 Oct. 2013.

"Lysosomal Disease - Extraordinary Measures - Research, Cure & Support Information - Sponsored by the MLD Foundation." Lysosomal Disease - Extraordinary Measures - Research, Cure & Support Information - Sponsored by the MLD Foundation. N.p., n.d. Web. 26 Oct. 2013.

"Lysosomal Storage Disease Program - Cedars-Sinai." Lysosomal Storage Disease Program - Cedars-Sinai. N.p., n.d. Web. 26 Oct. 2013.

"Nucleus." Biology Online. Biology-Online.org, 5 Dec. 2008. Web. 27 Oct. 2013. <http://www.biology-online.org/dictionary/Nucleus>.

Olsen, Mark OJ. "Nucleolus: Structure and Function." ELS Citable Reviews in the Life Sciences. Wiley Online Library, Dec. 2010. Web. 27 Oct. 2013. <http://www.els.net/WileyCDA/ElsArticle/refId-a0005975.html>.

"The Mitochondrial and Metabolic Disease Center." The Mitochondrial and Metabolic Disease Center. N.p., n.d. Web. 26 Oct. 2013.

"-The United Mitochondrial Disease Foundation." -The United Mitochondrial Disease Foundation. N.p., n.d. Web. 26 Oct. 2013.

"What Are Mitochondrial Diseases? - NAMDC." What Are Mitochondrial Diseases? - NAMDC. N.p., n.d. Web. 26 Oct. 2013.

"What Are the Functions of Lysosomes?" WiseGEEK. N.p., n.d. Web. 26 Oct. 2013.

"When Mitochondrial Genes Go Bad | Science/AAAS | News." When Mitochondrial Genes Go Bad | Science/AAAS | News. N.p., n.d. Web. 26 Oct. 2013.

Zimmer, Carl. "Self-Destructive Behavior in Cells May Hold Key to a Longer Life." NY Times. N.p., 05 Oct. 2009. Web. 26 Oct. 2013.
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