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Cannabinoids in immune modulation
Transcript of Cannabinoids in immune modulation
- Suppression of immune cell survival, proliferation
- Action depends on ligand and cell type, as well
as exposure time Basu and Dittel (Immunol Res (2011) 51:26-38) - Upregulation of anti-inflammatory cytokines
- Downregulation of pro-inflammatory cytokines
- Suppression of immune cell migration
- Induction of apoptosis Expression of CB1 and CB2 receptors What are cannabinoids? www.kindgreenbuds.com/marijuana-articles/cannabisscience.html Phytocannabinoids Endocannabinoids Synthetic cannabinoids Formed by humans, animals and some plants
2-arachidonoyl glycerol (2-AG)
Regulate energy balance and food intake
CB1/CB2 agonists Derived from plants
CBD -> THC -> CBN
CB1/CB2 agonists http://www.tumblr.com/tagged/cannabinoids www.kindgreenbuds.com/marijuana-articles/cannabisscience.html Synthetically produced
Many side-effects http://vaporblog.org/blog/ Immunomodulation by Cannabinoids Leontien van der Bent,
Wouter van den Braak, Tim Crolla,
Kim Duintjer, Renske Egberts,
Liza Wijler Medical use of cannabinoids Research of cannabinoids Cell migration
in vitro transwell migration assays Cell proliferation
[3H]-thymidine incorporation Apoptosis
TUNEL and fluorescence cytometry Cytokine production
ELISA Immunoglobulin class switching
ELISA Sarfaraz et al. 2008 Current applications:
Anti-emetic Future applications
in cancer Diseases
Cancer Disadvantages and pitfalls