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Cannabinoids in immune modulation

PGO presentation CBI-50806

Leontien van der Bent

on 22 November 2012

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Transcript of Cannabinoids in immune modulation

Basu and Dittel (Immunol Res (2011) 51:26-38) Immunomodulatory effects of CB2 activation - Downregulation of transcription factors

- Suppression of immune cell survival, proliferation
and differentiation

- Action depends on ligand and cell type, as well
as exposure time Basu and Dittel (Immunol Res (2011) 51:26-38) - Upregulation of anti-inflammatory cytokines

- Downregulation of pro-inflammatory cytokines

- Suppression of immune cell migration

- Induction of apoptosis Expression of CB1 and CB2 receptors What are cannabinoids? www.kindgreenbuds.com/marijuana-articles/cannabisscience.html Phytocannabinoids Endocannabinoids Synthetic cannabinoids Formed by humans, animals and some plants
2-arachidonoyl glycerol (2-AG)

Postsynaptically formed
Regulate energy balance and food intake
CB1/CB2 agonists Derived from plants
Psychoactive properties
CB1/CB2 agonists http://www.tumblr.com/tagged/cannabinoids www.kindgreenbuds.com/marijuana-articles/cannabisscience.html Synthetically produced
Many side-effects http://vaporblog.org/blog/ Immunomodulation by Cannabinoids Leontien van der Bent,
Wouter van den Braak, Tim Crolla,
Kim Duintjer, Renske Egberts,
Liza Wijler Medical use of cannabinoids Research of cannabinoids Cell migration
in vitro transwell migration assays Cell proliferation
[3H]-thymidine incorporation Apoptosis
TUNEL and fluorescence cytometry Cytokine production
Western Blot
ELISA Immunoglobulin class switching
ELISA Sarfaraz et al. 2008 Current applications:
Analgesic functions
Anti-neuropathic pain

Appetite stimulating
Anti-emetic Future applications
Apoptosis induction
in cancer Diseases
Alzheimer’s disease
Multiple sclerosis
HIV-related dementia
Cancer Disadvantages and pitfalls
Th1/Th2 dysbalance
Full transcript