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Japan SU Summit 2014 11 McCauley Digital Bio v10

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Raymond McCauley

on 29 August 2017

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Transcript of Japan SU Summit 2014 11 McCauley Digital Bio v10

DNA
Sequencing
+1-650-776-4561
for your attention
raymond@raymondmccauley.net
Raymond McCauley
biochemistry
biophysics
electrical engineering
computer science
bioinformatics
nanotechnology
genetic engineering
DNA sequencing
personalized health
DISCLAIMER
These are my opinions and are not intended to reflect the views of any group or organization with which I may be affiliated.
Exponential Biosciences
systems
biology
past:
Biotech Chair: Singularity U
Co-Founder: Playtpus Project
Co-Founder & Chief Architect: BioCurious
Principal: Exponential Biosciences

Current Research Areas:
Personal Genomics
Therapeutic Genetic Engineering
Low Cost Access to Biotech Tools
Cancer Dx and Treatment
Singularity
University
Raymond McCauley
@raymondmccauley
Thank you
Applications
good preview
of things to come
Biomimetics / Packaging
yogurt = finger food
WikiFood, WikiPearl
Dave Edwards, Harvard bioengineer
Nutrigenomics
Retail / Vertical Farming
Raymond McCauley
Coming of Age
in the Biotech Century
raymond@raymondmccauley.net
@raymondmccauley
hyperorganic, hyperlocal
pesticide & herbicide free
Fiesta Hypermart, Houston, Texas, 1991
10,000+ sq ft hydroponic produce dept
Houston's biggest tourist attraction
Backed by NASA CELSS research group
6 months
700 000 meals sold
$2+M revenues
biodegradable & delicious
protein-based packaging
Bob's, Brazil
just the beginning...
Courtesy Ruby Gadelrab, Invitae
Functional Foods
Conflicts
Medicine
Agriculture
Energy & Manufacturing
Biotechnology =
1/3 of Global Economy
& Financial Interests
Anthrocyte
Deloitte
Exogen
Genomera
GLG
Illumina
Intellimed
Platypus Project
QIAGEN
Singularity University
Verinata
WellPoint
Marked with throughout presentation.
*
Caterpillar
Disruption
is never
Expected
Personalized Foods &
Food for Thought...
Food
example: Okanagan Fruit Specialties
Not multinational, but family startup
Not implanted, but adjusted
Not labeled, but branded
What is Food?
Cocoa
$2.1B
Chocolate
$131.7B
by 2019...
shifting production
global warming, disease
genetic engineering
shifting consumption
Asian markets
production innovation
health benefits
source:
Cocoa & Chocolate Market - Global Trends & Forecasts to 2019.
Entire presentation copyright 2014 by Raymond McCauley
Disruption
Mother (Nature)
Biotech
or
is the
of all
2020
=
+
2001
=
ApE = A Plasmid Editor
Rise of the
Biotech
Garage
Inventor
bioprinter project
OpenPCR
$599 DNA Copy Machine
+
Industrial
Biology
Biohacking
Cow-Free
Milk & Cheese
Genetic
Engineering
Software Development
=
The
small
future
is
industrial microbiology
"Mary had a little microbe"?
gene prospecting
Microbial
Nation
Bacterial Reservoir
Eat ammonia
Eliminate smell
Crowd out
tinea pedis
Keep feet healthy
Peter DiLaura, CEO
Practical Advice
Use antibiotics wisely
Eat like ancestors
Get a dog
Citizen Science
& Crowd-Sourced
Metagenomics
Human
Prenatal Genetic Dx
Mitochondrial therapy
Germ line therapy
How long until
genetic engineering
for
humans
?
How long until
genetic engineering
for
adults
?
Future
of genetic engineering
ZFPs
TALENs
CRISPR/Cas9
$10000
$5000
$1000
Better, Cheaper, Faster
Genetic Engineering Tools
*
The
future
is
coming
fast
2010: discovered
2011: microbes
2012: plants, animals
2013: human cells, company
2014: patent fight
Drag and Drop
Genetic Engineering
TALENs
Transcription
Activator
Like
Effector
Nucleases
TALENs have modified genes in:
yeast
fruitfly
roundworm
cricket
zebrafish
frog
rat
pig
cow
thale cress
rice
silkworm
human somatic cells
pluripotent stem cells
Nature Reviews Molecular Cell Biology 14, 49-55 (January 2013)
http://www.brc.a-star.edu.sg/index.php?sectionID=12
hijacked from plant bacteria that genetically engineer their host plants
discovered by Bogdanove & Moscou, Iowa State University, in 2009
make double stranded breaks to knock-out and knock-in genes
Clustered
Regularly
Interspaced
Short
Palindromic
Repeats
hijacked prokaryotic immune system mechanism
discovered by Horvath & Barrangou, DuPont/Danisco, in 2010
immunize industrial bacteria
gene silencing in stem cells
CRISPRs
MSTN
LRP5
APP
CCR5
PCSK9
FUT2
Lean muscles
Extra-strong bones
Alzheimer’s-resistant
HIV-resistant
Lower coronary risk
Stomach flu resistant
Genes to Knock Out
adapted from George Church, private communication
Behavioral and Mental Traits
MAOA gene & aggression
last to implement
poorly understood
Therapeutics,
then
Enhancement
Gene Expression
"gene doping"
EPO, red blood cell production
Myostatin, muscle growth inhibition
VEGF, blood vessel production
IGF-1, targeted muscle mass increase
Qualified
Speculation
RNA-Guided Human Genome Engineering via Cas9
Prashant Mali, Luhan Yang, Kevin M. Esvelt, John Aach, Marc Guell, James E. DiCarlo, Julie E. Norville, and George M. Church
Science 15 February 2013

Multiplex Genome Engineering Using CRISPR/Cas Systems
Le Cong, F. Ann Ran, David Cox, Shuailiang Lin, Robert Barretto, Naomi Habib, Patrick D. Hsu, Xuebing Wu, Wenyan Jiang, Luciano A. Marraffini, and Feng Zhang
Science 15 February 2013
Academically (for reference)...
Commerically...
$43 million Series A , Nov 2013
Flagship Ventures
Polaris Partners
Third Rock Ventures
Partners Innovation Fund
TALENs
CRISPRs
Basic Research
Always Pays Off
Mitacs Accelerate's research internship program
NRC’s Industrial Research Assistance Program
CRA's Scientific Research and Experimental Development Tax Incentive
Gov't & Industry Cooperation in Canada
Drag & Drop Tools
DNA Synthesis
Lab Automation
Industrial Biology
Systems Biology
TALENs & CRISPRs
Renaissance in
Genetic Engineering
Industry Materials Energy Agriculture Medicine Research
Microbiomes
IVF/PGD
Genome
Editing
Microbiome Roles
Digest food
Synthesize nutrients
Protect against disease
Mood, sleep, eating behavior
Partnership with Mayo Clinic, 7 Oct 2014
inflammatory bowel diseases
metabolic disorders
colorectal cancer
1. Avoid excess sugary foods
2. Good quality sleep
3. Meditation and relaxation
4. Eat fiber
5. Eat natural probiotic foods
6. Consider probiotic supplements
The Gut Microbiome,
Anxiety and Depression:
6 Steps to Take
by Peter Bongiorno, ND, LAc
November 8, 2014
Jessica
Richman,
CEO
microbiome hacking
& DIY fecal transplants
Phage
Therapy
Use viruses to kill bacteria
Specifically targeted
Alternative to wide spectrum antibiotics
Developed in Russia, new Western interest
Image credit: Bacteriophages and Biotechnology
http://www.pharmainfo.net/luckypharmacist/bacteriophages
But not today...
CRISPR/Cas9
is a toolkit for
Genes
and regulatory regions
Knock-out
Knock-in
Repair
Edit
cheap
highly targeted
improvable
bluebird bio
Editas Medicine
GenSight
Lysogene
Spark
uniQure BV
Voyager Therapeutics
and others
Genetic Engineering
Therapeutics
Companies
they work,
everywhere
Athletic Sensors
Medical Sensors
200+ sensors
Car
Phone
You
12+ sensors
0 sensors
Edge
Scanadu
importance
of
hearing
to be a
cyborg
http://rockhealth.com/tag/wearables/
Wearables &
Implantables
now
next
wearables
implantables
We are
all
cyborgs
vaccination
biotechnological
artifact
Hannes Sjoblad
Singularity U Ambassador for Sweden
Biohacker and Body Hacker
hannes.sjoblad@singularityu.org
@BioNyfiken
Tom van Oudenaarden
Piercing Utrecht
www.piercingutrecht.nl
xNTi kit
RFID chipset
2x12mm cylindrical USP grade lead-free Schott 8625 biocompatible glass casing
Pre-loaded injection assembly
Use with 13.56MHz RFID systems & NFC

$99 from
dangerousthings.com
Biohackerspace in Sweden
RFIDs for 100 Project
my actual point
implants are easy
Privacy & Security Concerns
The Mark of the Beast?
There's an app for that!
very intimate...
Genome Editing with CRISPR-Cas9
Animation created by:
McGovern Institute for
Brain Research at MIT,
Feng Zhang, Sputnik Animation
open electronic locks
unlock smartphones
trade contact info
banking, cars, etc.
Shaping the oral microbiota
through intimate kissing
Remco Kort, Martien Caspers, Astrid van de Graaf, Wim van Egmond, Bart Keijser and Guus Roeselers
...we investigated the effects of intimate kissing on the oral microbiota of 21 couples by self-administered questionnaires about their past kissing behavior and by the evaluation of tongue and salivary microbiota samples in a controlled kissing experiment...
"
"
17 Nov 2014, in Amsterdam
brings up many questions...
Expose your kids
Raymond McCauley
+1-650-776-4561
Build a
biohacker
space
Get a Book
The Stuff of Life
by Mark Schultz
Illustrated by
Zander Cannon
& Kevin Cannon
Plague, Inc
Download an app
to biotechnology
(& yourself)
Kids & Biohacking
Cold Spring Harbor Labs Press
Childrens Books
igem.org
international
Genetically
Engineered
Machines
competition
Permanent Beta
Biohacking Community
permanentbeta.nl
RFID
Hackers:
Learn by
Doing
pain check...
ouch scale
flu shot
ear piercing
nipple piercing
genital piercing
watching
Showgirls
Full transcript