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The Use of Genetically Engineered E. Coli and Yeast to Produce Human Insulin

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julia provenzano

on 12 February 2013

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Transcript of The Use of Genetically Engineered E. Coli and Yeast to Produce Human Insulin

The Use of Genetically Engineered E. Coli to Produce Human Insulin Function of Insulin Hormone necessary to regulate blood sugar
Allows cells to take in glucose
Diabetics lack the ability to produce insulin
Inability to regulate glucose in blood stream and cells
Made up of chains A and B, somewhat complex quaternary structure Genetically Engineered E. Coli Human insulin genes inserted into E. Coli plasmid
Enables E. Coli to produce the protein insulin through protein synthesis Basic Procedure of Inserting the Human Insulin Gene into an E. Coli Plasmid 1.) Synthesize human insulin genes (artificial gene synthesis)
2.)EcoR1 inserted to cut plasmid at specific group of genes all activated by lactase
3.)Two human insulin genes inserted into the DNA of the plasmid
4.) Ligase stitches up DNA
5.) Results in recombinant DNA
6.) Genetically engineered E. Coli replicates Risks No proven side effects
Complaints of lethargy and depression
Insulin exact chemical make up Benefits Large quantities of insulin produced
Meet demand for insulin
More accessibility to insulin
Lower cost for insulin
No allergic reactions My Opinion Only has benefits
Use of genetically engineered E. Coli not controversial
First created in 1978, best solution currently to manage diabetes Works Cited "Use of Biotechnology in Pharmaceutical Manufacturing." Wikipedia. Wikimedia
Foundation, 27 Jan. 2013. Web. 09 Feb. 2013. <http://en.wikipedia.org/wiki/Use_of_biotechnology_in_pharmaceutical_manufacturing>. "Insulin Synthesis." Insulin Synthesis. News Medical, n.d. Web. 09 Feb. 2013.
<http://www.news-medical.net/health/Insulin-Synthesis.aspx>. "What Was The First Commercial Use Of Genetic Engineering?" What Was The First
Commercial Use Of Genetic Engineering? N.p., n.d. Web. 12 Feb. 2013. <http://www.biotech.wisc.edu/outreach/poster/firstcommerce.html> "Synthetic Insulin :: DNA Learning Center." DNALC Blogs. N.p., n.d. Web. 12 Feb.2013.
<http://www.dnalc.org/view/15926-Synthetic-insulin.html>.
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