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C Diff Super Bug
Transcript of C Diff Super Bug
Research and Conferences
The Future of C. Diff
What is it resistant to?
Fecal Microbiota Transplant
Effects on the Body
Patients with C. diff treated differently
Gloves and gowns
Remain in room as much as possible
What does it do
Gram Positive, spore-forming, anaerobic rod-shaped bacteria
Produces 2 exotoxins (A and B)
Cause of 25% of antibiotic-associated diarrhea
Can lead to other diseases such as:
pseudomembranous colitis (PMC)
perforations of the colon
Discovered in 1957
Resistance in about 8% of USA strains in 2013
Discovered in 1952
Used to treat antiobiotic
Binds to RpoB (beta unit) of RNA Polymerase, inhibits chain initiation
Used to treat parasitic bacterial infections
Total Abdominal Colectomy
Diverting Loop Ileostomy
Highly specific antibdies from llamas may be used to control infections
2013 APIC Clostridium difficile Educational and Consesus Conference
First used in 1958
Restores microbiota in intestines
Donar feces is harvested and screened
Feces is diluted
nasogastric/duodenal tube (79%)
Caution with body fluids
Broad spectrum antibiotics
Target topoisomerases II and
Discovered in 1962
C. Diff resistance found in
Small, ubiquitous bacteria
Motile, prevalent in soil
Spores survive in intestine
Coupled with antibiotics, spores can cause problems
This can lead to more
Hospital Acquired Infection
Rooms and Equipment
Antibiotics only given when necessary
14,000 people die as a result of C. diff
every year in the U.S.
25% of all HAIs
Most lethal HAIs
The U.S. spends an average of $2
billion every year treating it
Not a lost cause
"When bacteria don't respond to the drugs designed to kill them"
-Center for Disease Control