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C Diff Super Bug

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Lainee Bulawa

on 28 April 2014

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Transcript of C Diff Super Bug

Clostridium difficile
Phage Therapy
C. Difficile
Viterbo Nurses
Wisconsin Hospitals
Research and Conferences
The Future of C. Diff
Wrap Up
What is it resistant to?


What Works?
Fecal Microbiota Transplant
Effects on the Body
Patients with C. diff treated differently
Single room

Gloves and gowns

Wash hands

Remain in room as much as possible
What does it do
Gram Positive, spore-forming, anaerobic rod-shaped bacteria

Produces 2 exotoxins (A and B)

Cause of 25% of antibiotic-associated diarrhea

Can lead to other diseases such as:

pseudomembranous colitis (PMC)

toxic megacolon

perforations of the colon



Discovered in 1957
Resistance in about 8% of USA strains in 2013
Discovered in 1952
Class: Nitroimidazoles
Class: Glycopeptide
Used to treat antiobiotic
induced Colitis
Binds to RpoB (beta unit) of RNA Polymerase, inhibits chain initiation
Used to treat parasitic bacterial infections
Total Abdominal Colectomy

Diverting Loop Ileostomy
Colonic Lavage
Highly specific antibdies from llamas may be used to control infections
2013 APIC Clostridium difficile Educational and Consesus Conference
Specific targets
Antibiotic stewardship
First used in 1958
Restores microbiota in intestines

Donar feces is harvested and screened
Feces is diluted
Delivered via
colonoscopy (91%)
nasogastric/duodenal tube (79%)
Contact isolation
Caution with body fluids
Severe illness
Broad spectrum antibiotics

Target topoisomerases II and

Discovered in 1962

C. Diff resistance found in
Small, ubiquitous bacteria

Motile, prevalent in soil

Produces spores
Spores survive in intestine

Coupled with antibiotics, spores can cause problems

This can lead to more
serious diseases
Hospital Acquired Infection

Wash Hands

Rooms and Equipment

Antibiotics only given when necessary
14,000 people die as a result of C. diff
every year in the U.S.

25% of all HAIs

Most lethal HAIs

The U.S. spends an average of $2
billion every year treating it
Double whammy

Urgent problem

Not a lost cause
Antibiotic Resistance
"When bacteria don't respond to the drugs designed to kill them"
-Center for Disease Control
Full transcript