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Red Blood Cells

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by

Emerald Sia

on 3 February 2014

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Transcript of Red Blood Cells

Effects of Hyperglycaemia on Mean Cell Volume of Red Blood Cells Analysed by Sysmex XE-5000
20mmol/L
50mmol/L
40mmol/L
30mmol/L
10mmol/L
10/20/30/40/50mmol/L
1
2
3
4
5
6
7
8
9
10
p-value: 0.189
p-value: 0.286
p-value: 0.059
p-value: 0.811
p-value: 0.110
p-value: 0.410
p-value: 0.715
p-value: 0.636
p-value: 0.161
p-value: 0.386
p-value = 0.005
p-value = 0.024
p-value = 0.018
p-value = 0.016
p-value = 0.004
p-value = 0.025
p-value = 0.003
p-value = 0.010
p-value = 0.305
p-value = 0.014
p-value = 0.009
Fick's Law of Diffusion
1. Active Transport
Effect of Diluent
In vivo
In vitro
Transport Mechanisms
Incubation Time
Different Haematology Analyzers
Higher Glucose Concentrations
Future Directions
Blood from Individual for Each MCV Category
Conclusion
1. MCV is affected
by high glucose concentrations
using Sysmex XE-5000
2. The changes are not time-dependent
Supervisor:
Ms Kwek Cheah Yee
Sysmex XE-5000
Red Blood Cell INDICES

Haemoglobin (Hb)
Mean Cell Volume (MCV)
Mean Cell Haemoglobin (MCH)
Mean Cell Haemoglobin Concentration (MCHC)
Haematocrit (HCT)
Red Blood Cell Count (RBC)
1. MCV is affected by high glucose concentrations in samples analysed by Sysmex XE-5000

2. The changes are time-dependent
aim
Our Project:
Discussion
Hans L.P. van Duijnhoven, Marco Treskes (1996), Marked Interference of Hyperglycemia in Measruements of Mean (red) Cell Volume by Technicon H Analyzers, Clinical Chemistry, 42(1), pp. 76
Glucose level 97mmol/L
MCV 111 fL

Glucose level
MCV 90 fL
Hans L.P. van Duijnhoven, Marco Treskes (1996), Marked Interference of Hyperglycemia in Measruements of Mean (red) Cell Volume by Technicon H Analyzers, Clinical Chemistry, 42(1), pp. 76
Emerald Sia
Diyan
Effects of Hyperglycaemia on Mean Cell Volume of Red Blood Cells Analysed by Sysmex XE-5000
Effects of Hyperglycaemia
on Mean Cell Volume oF Red Blood Cells Analysed by sysmex Xe-5000

Acknowledgement
3. Altered Diffusion
2. Facilitated Diffusion
10mmol/L
50mmol/L
40mmol/L
30mmol/L
20mmol/L
60mmol/L
80mmol/L
100mmol/L
120mmol/L
For eg. Low MCV
10mmol/L
30mmol/L
40mmol/L
20mmol/L
50mmol/L
4 hours
>4 hours
15 min
60 min
120 min
180 min
240 min
15 min
30 min
60 min
90 min
120 min
150 min
180 min
210 min
240 min
1
2
3
4
5
6
7
8
9
10
1
2
3
4
5
6
7
8
9
10
Saline
Glucose
Co-Supervisor:
Mr Edmund Lui
Lecturers:
Ms Sharon Quek
Dr Simon Tan
Khoo Teck Puat Hospital:
Frederick Ilagan
*
p-value= 0.001
p-value= 0.002
p-value= 0.202
*
*
*
*
*
*
*
*
*
*
*

Glucose level 64mmol/L
MCV 91 fL

Glucose level 11.5mmol/L
MCV 85.5 fL
p-value: 0.281
p-value: 0.271
p-value: 0.361
p-value: 0.945
p-value: 0.504
Admitted into hospital:
After treatment:
Admitted into hospital:
After Treatment:
Conclusion
Priscilla Foo
Non-Impedance Haematology Analyzer
> 40mmol/L
Conclusion
+
Further biochemical tests
> 40mmol/L
Glucose Concentrations

Coulter LH-500
Cell-Dyn Ruby
Siemens Advia 120
5 time intervals: 15 minute, 60 minte, 120 minute, 180 minute and 240 minute.
Full transcript