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Exo WAVE McCauley Austin 2018 02

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Raymond McCauley

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Transcript of Exo WAVE McCauley Austin 2018 02

Investment Syndicate
+1-650-776-4561
for your attention
Raymond McCauley
biochemistry
biophysics
electrical eng.
computer science
bioinformatics
nanotechnology
DISCLAIMER
These are my opinions and are not intended to reflect the views of any group or organization with which I may be affiliated.
Exponential Biosciences
past:
Raymond McCauley
@raymondmccauley
Thank you
Conflicts
& Financial Interests
Anthrocyte
Deloitte
Exogen
Genomera
GLG
Illumina
Intellimed
Platypus Project
QIAGEN
Singularity University
Verinata
WellPoint
Marked with throughout presentation.
*
Entire presentation copyright 2014 by Raymond McCauley
advisor,
consultant,
investor
Raymond McCauley
raymondmccauley
on Google, LinkedIn & Twitter
+1-650-776-4561
Creative Commons
Attribution-NonCommercial
4.0 International
READING DNA
WRITING DNA
HACKING DNA
2013
=
2007
=
2015
=
+
2001
=
+
+
2018
2022
=
=
=
Source: National Human Genome Research Institute, Exponential Biosciences,
Aug 2017
$999 genome sequencing
$80 exome sequencing
+ interpretation
+ access to
app store
$199 BRCA testing
+ interpretation
+ counseling
+ updates
$29 superhero testing
+ scans variants for
strength
intelligence
speed
+ counseling
+ cape
for qualifying
individuals
veritasgenetics.com
getcolor.com
helix.com
orig3n.com
genomics
In the era of the
$1000 Genome
and racing toward the
$100 Genome
cheap genomes
cancer systems biology
+
=
simple blood tests for cancer
The End of
Mammograms
Colonoscopies
&
?
2017
human genomes
but still slow progress on
complex genetic diseases
first
1 million
and
is now
>
But only by reducing reports
from
200+
to
30+
microorganisms = factories
synthetic biology
industrial biology
industrial chemicals - food - agriculture textiles - biofuels - medical research
or
DNA = blueprints
new factories = exponential
& portable
sustainability
price & supply chain disruption
1.5 million
customers?
igital
D
iology
B
More Human Embryos Edited by CRIPSR
Zika
& gene drives
rapidly push
new DNA through
whole population
in the wild
CRISPR/Cas9
is a Swiss Army Knife for
Genes
and regulatory regions
Knock-out
Knock-in
Repair
Edit
cheap
highly targeted
improvable
they work,
everywhere
Human
Infertility
Prenatal Genetic Dx
Mitochondrial Therapy
Germ-Line Therapy
Enhancement
- Disease Risk
+ Intelligence
+ Longevity
NOW
NEXT
genetic
engineering
GMOs

3.0
Genetically Modified Organisms
better yield
better nutrition
better digestion
drought tolerance
saline soil tolerance
fungus resistance
virus resisitance
24 Aug 2017
Cellular Agriculture
Mark Post
Explosion of
consumer genomics
250+ companies
Ancestry
Athletic
Child talent
Matchmaking
Surreptitious
Non-legal paternity
Legal paternity
Nutrigenomics
Family
Carrier
Health testing
Microbiome
Pets
Food
desktop bioproduction lab
$1699
reprogram
microbes
Rise of the
Biotech
Garage
Inventor
bioprinter project
OpenPCR
$599 DNA Copy Machine
+
Cow-Free
Milk & Cheese
Boston
Paris
San Diego
Seattle
Oakland
Portland
Manchester UK
Biologigaragen
Biospace
Victoria, Canada
Copenhagen
Switzerland
Brooklyn
Sao Paolo
San Francisco
Shenzhen
Tokyo
Bio
Garage
Baltimore
Syn
Bio
Brasil
Launched at Singularity U 2014 Global Solutions Program
*
First clinical study, for gastric cancer, with Hospital Clínico Universidad Católica de Chile
microRNA diagnostics in low resource settings
Targeting emerging economies
Initial work completed at BioCurious in 5 weeks
Indie.bio, 479 Jessie Street, San Francisco, CA
sf.indiebio.co
Indie.bio, San Francisco
Counter Culture Labs, Oakland
Berkeley Biolabs, Berkeley
Janssen Labs + QB3, 953 & UCSF
Bay Area Biohackers
& Small Startup Labs
as New Models
Techshop
indie.bio
Hacker Dojo
Noisebridge
DARE2mansion
Hackteria
FabLab / HTGAA
Target CoLab
Janssen Labs
Silicon Valley
International
Corporate
National
Startup Chile
Hackerspaces
microRNA for diagnostics
EpiPen
Hack
$30 EpiPencil
Four Thieves Vinegar Collective
?
?
?
?
$1200 qPCR
Chai Biotech
Interpretation Websites
Promethease / SNPedia
Interpretome
LiveWello
Genetic Genie
23andMe
Ancestry.com
FamilyTreeDNA
Sources of DTC Genetic Data
buscando un bioinformático
coming
soon:
Fuel
?
Welcome to the
Consumer Genomics
Biohacking
Breakout Session
and/or
Raymond McCauley
Digital Biology:
@raymondmccauley
+1-650-776-4561
Life Is the New Black
Amniocentesis
Non-Invasive
Prenatal Testing
versus
simulated photo, courtesy Natera
World’s biggest database of DNA
40+ million people
China’s Ministry of Public Security
12.7 million offender profiles
migrant workers
college students in high theft areas
Xinjiang Uyghur Autonomous Region
passport applicants, since Sept 2016
source: Human Rights Watch
ConservationX Labs
DNA Barcode Scanner
Maastricht University, Technical University Eindhoven, Singularity University
Human Embryos Edited by CRIPSR - HIV immunity?
April 2016
in United States, previously in China
to correct heart disease (MYBPC3 cardiac myopathy)
Cellular Agriculture
positives
fewer environmental impacts
safer, purer product
more consistent supply
no harm to animals
real world examples
meat with healthier fats
milk without lactose
eggs without cholesterol
rhino horn with no extinction
negatives
the "ick" factor
adapted from New Harvest
* not necessarily genetic engineering
MSTN
LRP5
APP
CCR5
PCSK9
FUT2
SLC30A8
Lean muscles
Extra-strong bones
Alzheimer’s-resistant/immune
HIV-resistant/immune
Lower coronary risk
Stomach flu resistant
Type 2 Diabetes
Genes to Knock Out
adapted from George Church, private communication
Behavioral and Mental Traits
MAOA gene & aggression
last to implement
poorly understood
Therapeutics,
then
Enhancement
Gene Expression
"gene doping"
EPO, red blood cell production
Myostatin, muscle growth inhibition
VEGF, blood vessel production
IGF-1, targeted muscle mass increase
redneck
genetic
engineering
Expresión genética
"dopaje genético"
EPO, producción de hematíes
Miostatina, inhibición del crecimiento muscular
VEGF, producción de vasos sanguíneos
IGF-1, incremento de masa muscular orientada
Locus of Control:
Individuals, Parents, Doctors, Legislators
Widening the Economic Gap
Different Nations & Societies
= Diverse Approaches
Ethics, Laws and Policies
Overcoming
Fear of Other / Fear of Change / Every SciFi Movie Ever
Garage Labs
PCR Machine
Gel Electrophoresis
Fridge & Freezer
Water & Bleach

Biosafety Cabinet
Scale & pH Meter
Photospectrometer
basic equipment set
bicycles & woodworking optional
Laptop & Wifi
Biohazard Disposal
Centrifuge
Pipettors
Autoclave
Multimeter
3D Printer
getting fancy
Biohacking
Resources
for Kids
bit.ly/kidbiohack
Copyright 2018, Raymond McCauley. All Rights Reserved.

Build Our Biotech Future
What do you do
when you have access to potentially
the most dangerous technology
the human race has ever seen?
Put it in the hands
of 5 year olds
as quickly as you can
Alzheimer's
Autism
Cerebral Palsy
Huntington's
Parkinson's
Stroke
Traumatic Brain Injury
Alopecia
Baldness
Burn
Cosmetic
Incision Recovery
Wound Healing
Facelift
Skin Resurfacing
Macular Degeneration, Cataracts
Deafness
Breast Augmentation
Breast Reconstruction
Kidney Regeneration
Liver Regeneration
Pancreas Regeneration
Intestine Regeneration
Heart Attack Repair
Heart Valve Replacement
Heart Regeneration
Bladder Regeneration
Genital Replacement
Infertility
Arthritis
Joint Injury Repair
Cancer Innate Immunity
HIV Treatment
Lupus
Multiple Sclerosis
Copyright 2016, Raymond McCauley, All Rights Reserved
Adapted from Paul Knopfler, Stem Cells, An Insider's Guide
Back Pain
Spinal Cord Regeneration
Stem Cells = Reprogramming Medicine
A hackerspace for biotech

First biohacker lab in the world

Committed to making biotech
accessible, affordable, and open to everyone

Located in Sunnyvale, California

501c3 all-volunteer community lab, supported by monthly memberships and classes
most innovative
education company
in the world
Top
100
#4
Prof. Tulio de Oliveira,
and collaborators
Drive innovation in global health
Reverse the brain drain
Academic, govermental, and commercial
Work on HIV, TB, drug resistance

Platypus
Project
Applying exponential technology
to global grand challenges
Pharmacogenomics at scale
for health systems
Edtech for biology hacking
Raymond McCauley - Current Work
I0
Base
Copyright 2017, Raymond McCauley. All Rights Reserved.
Alltech
Beyond Meat
CellPod
Clara Foods
Hampton Creek
Impossible Foods
Modern Meadows
Nutrigene
Perfect Day/Muufri
Shojinmeat Project
Six Foods
Soylent
Initiatives
To
Watch
New Foods Sector
Microbiomes
& Metagenomics
Weight Loss Success Determined by
Two Gut Microbiota Species
uBiome
Not conglomerate, but family orchard
Not implanted genes, but adjusted genes
Not hidden, but branded and labelled
Okanagan Specialty Fruits
Canadian company acquired by Intrexeon, Feb 2015, $41M
Simplot Innate Potato
Digital Agriculture
Farmville
Zynga
nutrigenomics
farm robotics
biomimicry
crop de-extinction
soil microbiomes
livestock genomics
water remediation
radical polyculture
bioculture
sensing (vision)
aquaculture
heterotrophic algae
bioenergy
data-intensive farming
pharming / manufacture
food security
genetic engineering
tissue engineering
animal-free protein
food tracking
supply chain automation
hyperspectral imaging
GMOs
digital labels
Digital
Agriculture
microirrigation
Ag biotech tracking map for World Bank, 2017
Copyright Raymond McCauley
exoproteins
cellular agriculture
environmental reclamation
*
*
*
*
*
Not
this kind of Digital Agriculture...
Advisor & Investor
Various Media Projects
programming bacteria
to monitor water quality
www.fredsense.com
portable, fast, easy, accurate biosensors
Calgary-based industrial biotech startup
"White Supremacists, You Won't Like Your Tests Results"
&
Arctic Apples
"gene-silenced"
September 2017, Arne Astrup, et al, University of Copenhagen
@LIVCPH
for Innovation
and Accelerators
Aubrey
de Grey
Chief Science Officer
SENS Research Foundation
Longevity
People and Nations
Get Richer
Work Longer
More Education Time
Hyperexperience
Financial Behaviors Change
Underestimate Savings Need
Health Care Costs Increase
Active Retirements
Pensions Recalculated
Inheritance Decrease
the Longevity Dividend
+ 3.0 months / year
+ 2.5 months / year
Radical Biotechnology
& Fintech
Old Institutions Break
Insurance
Pensions
Retirement
Social Security
people aged 50+ equal
a global market nearly the size of China
Longevity Escape Velocity
current progress towards
}
demographics shift
Find me on
and

@LIVCPH
Raymond McCauley, @raymondmccauley
& New Food
Yuki
Hanyu,
Tokyo
DIY cultured meat
+ desktop myoformers
+ manga
working on
$499
and
$199
models

Investment Syndicate
Platypus
Project
Applying exponential technology
to global grand challenges
Edtech for biology hacking
Raymond McCauley - Current Work
Advisor & Investor
Various Media Projects
&
CAR-T
Chimeric
Antigen
Receptor
T-Cell
Therapy
A type of adoptive cell transfer (ACT)
Collect patients’ own immune cells
Program disease recognition regions
Kymriah
Kymriah (tisagenlecleucel) from Novartis
Targets CD19 protein, on cancerous B cells
First FDA approved CAR-T, 30 Aug 2017
Treats acute lymphoblastic leukemia (ALL)
first gene therapy in US
first FDA approved CAR-T
first personalized drug?
cons: $475K a dose, complicated process, cytokine storm
pros: "wonder drug" - about half in remission after 12 months
{
HOW TO PRONOUNCE
Kim

Kardashian
Ma
riah

Carey
+
Source: @abbynac
Yescarta
axicabtagene ciloleucel
large-B-cell lymphomas
approved 18 Oct 2017
Kymriah
tisagenlecleucel
acute lymphoblastic leukemia
approved 30 Aug 2017
JCAR017, PLAT-0x
axicabtagene
NHL, ALL
in trials
Amgen, Celegene, Bellicum Pharma, Cellectis,
Johnson & Johnson, Juno, Kite/Gilead, Novartis, Pfizer, Unum Therapeutics
AGTC, Audentes, Avalanche Biotech, Biomarin, Biogen Idec, Celladon, Dimension Thera, GSK, Noavartis, Shire, Spark Thera, uniQure, Voyager
Crispr Thera, Editas, Intellia, Sangamo,
More CAR-T
Gene Therapy
Gene Editing
What Happens Next in CAR-T
Selected Companies
Discount code:
BLOODMUSIC at checkout
"EZ Bake Oven for Genetic Engineering"
Then:
Chemistry Kit
Now:
Biology Kit
Old World
New World
Why Digital Biology?
Santiago Ramón y Cajal
From Madrid, Spain
Father of modern neuroscience
C. elegans
worm, 1 mm long
has 959 cells
302 are neurons
6393 synapses
OpenWorm.org
Building the world's first digital life form. Open source.
1906 Nobel Prize
Can digitally model and simulate the worm's nervous system
*
Adapted from Stephen Larson and Matteo Cantarelli
Courtesy of Tim Busbice
Courtesy of OpenWorm
Courtesy of OpenWorm
Courtesy of Bio-Rad
Cognitive
Genomics
+
Testing
then
Embryo Selection
then
Genetic Manipulation
Liquid Biposies
2.5M?
Ancestry.com
, 2.2M
23andMe
USA FBI’s national DNA index
In US grocery stores as of mid Nov 2017
consumer features
CRISPR Home Movie
Adapted from Nureki, et al "Real-space and real-time dynamics of CRISPR-Cas9 visualized by high-speed atomic force microscopy"
Nature Communications
Nov 2017, doi:10.1038/s41467-017-01466-8
First (official) gene-therapy in body
At UCSF Beniof, 44 year-old Brian Madeux
Hunter's Syndrome (missing enzyme in carbohydrate metabolism)
Most die before teens
Replaces 2-3x weekly enzyme transfusions $100Ks/year
one delivery virus + one gene + 2 ZFPs
developed by Sangamo Therapeutics
Adapted from "AP Exclusive: US scientists try 1st gene editing in the body",
AP News
, 15 Nov 2017
frequent colds and ear infections, distorted facial features, hearing loss, heart problems, breathing trouble, skin and eye problems, bone and joint flaws, bowel issues and brain and thinking problems.
Hunter Syndrome Symptoms
“I’ve been waiting for this my whole life, something that can potentially cure me.”
A Rough Guide / Some Modest & Practical Suggestions
Nov 2017
Josiah
Zayner
Former NASA biologist
Self-experimenter
DIY GE kits at the-odin.com
Dangerous?
Reportedly, athletes are hacking genes
in
muscle groups, bloodstream, lung surface, and microbiome
, for
energy, endurance, metabolism, hormone increase, recovery, and cognition
.
Discount code:
BLOODMUSIC at checkout
"EZ Bake Oven for Genetic Engineering"
A hackerspace for biotech

First biohacker lab in the world

Committed to making biotech
accessible, affordable, and open to everyone

Located in Sunnyvale, California

501c3 all-volunteer community lab, supported by monthly memberships and classes
Brian Hanley, Butterfly Sciences;
GHRH for life extension, hyperimmunity, 2016
Elizabeth Parrish, BioViva,
telomerase & Alzheimer's treatments, 2015
Aaron Traywick & Tristan Roberts; Ascendance Biomedical, antibodies for HIV; herpes vaccine, fat/muscle control, 2016
Josiah Zayner, The Odin; GFP & myostatin, 2017
Examples of DIY Genetic Engineering
dangerously irresponsible? or pioneers?
biohacking
versus
body hacking
Bodyhacking
v. Biohacking
First
First (unofficial) gene-therapy in body
How to Raise Superheroes
Allowance in Bitcoin/Ether
Kindle with lots of good & inspiring Sci-Fi books
My Brother is a Superhero
Solomons
Wizard of Earthsea
Le Guin
Have Spacesuit Will Travel
Heinlein
Blood Music
Bear
DIY Projects -
Make
Magazine, Amino Labs
One evening a month -- Indiegogo & Kickstarter
Screen time with closed captioning & second audio channel = superior reading and language acquisition
images Tim Peacock for MIT Tech Review & National Institute of Health
Drag and Drop
Genetic Engineering
Bone Marrow Transplants
Pharmacogenomics
Traditional Treatment
Personalized Treatment
+
Adapted from Genesis Genome
Human Organs-on-a-Chip
drug testing
personalized medicine
microfluidics
lung on a chip image
courtesy Harvard Wyss Institute
Where
does
this
lead?
doi.org/10.1161/01.cir.0000032876.55215.10
3D Printed Hearts?
stem cell-derived
heart tissue grafts
(& pancreas grafts)
First we will see
(Redneck Genetic Engineering)
SELF-DRIVING CARS
DRONES
Disease Identification
Is it a Cold
or a Virus?
under $20
in 20 minutes
Cheap qPCR
Biodefense
Basis Biodefense Monitoring System
Lifesaving Drones
TODAY
megaphone
camera
inflatable rescue pod
human-operated
AI-monitored

Resuscitation
Delivery
Emergency Transport
Situational
Awareness
Martin Jetpack
Volocopter
Dubai UAE, 2019
New Zealand, $200K, 2016
parachutes included
Zipline
Drone delivery of medical supplies
Zimbabwe since 2015
current killer app
future killer app
World's first fully self-driving ride
on public roads
Steve Mahan (legally blind)
in Austin, Dec 2016
37K Americans killed in car accidents in 2016
1.2M people worldwide killed by cars annually
40%+ of fatalities due to DUI
90%+ of fatalities due to "human errors and deficiencies"
Cars produce about 25% of greenhouse gases
19 companies promise self-driving cars by 2021
Waymo logged 3+ million self-driving miles
When will we have
self-driving cars
?
the numbers
smart money:
affordable in 8-10 years (2028)
95% of new purchases by 2039
My prediction
not smart money?
smarter money?
by 2032, half of all rides/mileage
are in self-driving cars
Subscription
versus
Ownership
Massive Public Subsidies
2 reasons
Self-Driving Ambulances?
No
or not for critical care
self-driving cars
Uber
versus
Ambulance
Ubulance?
Madison McVeigh/University of Kansa
7% decrease in ambulance use
after 18 months,
less critical cases
Modular
Hospital?
Deploy emergency vehicles where needed
Mobile hospital units (diagnostics, labs)
More efficient, more convenient
50%+ of people said "no way"
ARTIFICIAL
INTELLIGENCE
Some things it is good for
Some things it is
not
Complexity, Big Data,
Pattern Analysis,
Classification,
Some
Diagnostics
Judgement, Big Picture
Big Brother
Big Sister
Downside of too much data?
Full transcript