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Vitamin B12 Presentation
Transcript of Vitamin B12 Presentation
Pernicious anemia - no intrinsic factor Insufficient HCl and Intrinsic Factor:
Atrophic Gastritis (10-30% of older adults)
Gastrointestinal disorders (ie, GERD, Ulcers)
Certain Medications to treat the above disorders (ie, Prevacid for GERD) Cells of small intestine recognize only IF-B12 complex DNA synthesis Proper Neuron Function Deficiency Symptoms:
Megaloblastic Anemia - fatigue, weakness, constipation, loss of appetite.
more severe in infants - failure to thrive.
Neurological symptoms, at worst confusion and Demensia. Strict vegetarians and women who are pregnant or lactating have special Vitamin B12 needs. Can be treated with large oral doses, intramuscular injections or a gel nasal spray. RDA: 0–6 months = 0.4 mcg *
7–12 months = 0.5 mcg *
1–3 years = 0.9 mcg
4–8 years 1.2 mcg
9–13 years = 1.8 mcg
14+ years = 2.4 mcg
pregnancy = 2.6 mcg
lactation = 2.8 mcg
* Adequate Intake Foods High in Vitamin B12:
Clams, 3 oz = 84.1 mcg
Beef liver, 3 oz = 70.7 mcg
Mussels, 3 oz = 20.4 mcg
Oyster Stew, 1 cup = 15.4 mcg
Crab, 3 oz = 8.8 mcg
Salmon, 3 oz = 4.8 mcg
(25% DV = 1.5 mcg; 100% DV = 6.0 mcg)
Milk, low-fat, 1 cup = 1.2 mcg
Swiss Cheese, 1 oz = 0.9 mcg
Egg, 1 hard boiled = 0.6 mcg
Chicken Breast, 3 oz = 0.3 mcg *After absorption: Enterohepatic circulation for reabsorption Metabolic Functions: Malabsorption in small intestine possible:
Type II Diabetic taking Metformin
Dietary Deficiency risks:
excessive folate intake