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Vitamin B12 Presentation

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by

Michelle Cushing

on 21 November 2012

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Transcript of Vitamin B12 Presentation

Metabolic Pathway, etc. Vitamin B12 (Cobalamin) Animal Proteins Most people who eat animal foods eat enough to meet their Vitamin B12 needs. Vitamin B12 bound tightly to animal proteins HCl in stomach denatures proteins and releases Vitamin B12 Releasing and rebonding Vitamin B12 Small Intestines Red Blood Cell formation Vitamin B12 is not tightly bound to protein in fortified (non-animal) foods HCl intrinsic factor Vitamin B12 Intrinsic Factor binds to free Vitamin B12 to carry it to small intestines Non-diet related deficiencies:
Pernicious anemia - no intrinsic factor Insufficient HCl and Intrinsic Factor:
Atrophic Gastritis (10-30% of older adults)
Gastrointestinal disorders (ie, GERD, Ulcers)
Gastrointestinal surgeries
Certain Medications to treat the above disorders (ie, Prevacid for GERD) Cells of small intestine recognize only IF-B12 complex DNA synthesis Proper Neuron Function Deficiency Symptoms:
Megaloblastic Anemia - fatigue, weakness, constipation, loss of appetite.
more severe in infants - failure to thrive.
Neurological symptoms, at worst confusion and Demensia. Strict vegetarians and women who are pregnant or lactating have special Vitamin B12 needs. Can be treated with large oral doses, intramuscular injections or a gel nasal spray. RDA: 0–6 months = 0.4 mcg *
7–12 months = 0.5 mcg *
1–3 years = 0.9 mcg
4–8 years 1.2 mcg
9–13 years = 1.8 mcg
14+ years = 2.4 mcg
pregnancy = 2.6 mcg
lactation = 2.8 mcg
* Adequate Intake Foods High in Vitamin B12:

Clams, 3 oz = 84.1 mcg
Beef liver, 3 oz = 70.7 mcg
Mussels, 3 oz = 20.4 mcg
Oyster Stew, 1 cup = 15.4 mcg
Crab, 3 oz = 8.8 mcg
Salmon, 3 oz = 4.8 mcg
Breakfast cereal
(25% DV = 1.5 mcg; 100% DV = 6.0 mcg)
Milk, low-fat, 1 cup = 1.2 mcg
Swiss Cheese, 1 oz = 0.9 mcg
Egg, 1 hard boiled = 0.6 mcg
Chicken Breast, 3 oz = 0.3 mcg *After absorption: Enterohepatic circulation for reabsorption Metabolic Functions: Malabsorption in small intestine possible:
Type II Diabetic taking Metformin
Dietary Deficiency risks:
strict vegetarian/vegan
excessive folate intake
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