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Kidney Disease

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by

Malak Kourani

on 13 February 2016

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Transcript of Kidney Disease

Signal transduction pathway
Cell Signaling pathway involved
Correct Mechanism
Incorrect Mechanism

Kidneys have millions of units called Nephrons that have a glomerulus attached to a tubule

Blood is sifted into these blood vessels while extra fluid passes to the tubule

Chemicals and water are filtered from fluid

Urine is the final product being passed
PC1
and the
PC2
Decrease cell size
modifiy differentiation apoptosis and proliferation
promote planar cell polarity
decrese cell growth
decrese cell division
$1.25
Friday, October 31, 2014
Vol XCIII, No. 311
Causes and Core Symptoms
What is Kidney Disease?
Function of kidney disease


Causes Include:
Uncontrollable blood pressure and sugar
Blocked Renal Artery
Medicines that may damage kidneys


Symptoms Include
Urinating less than usual
Being Drowsy
Loss of appetite
Sick feeling
Headaches


Graphics of Pathway
K
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D
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Current Direction of Research
Stem Cells
Scientists are looking for Stem Cells in the human body
Group of cells on Bowman's capsule of the neuron
Looking at places in the tubules
Looking for Induced Pluripotent Stem Cell (iPSC) that can spread into any cell or tissue
iPSC has been used to make Kidney cells
Treatment for Stem cells is progressing but not there yet
http://www.wiley.com/college/boyer/0470003790/animations/signal_transduction/signal_transduction.htm

Healthy Kindney


Diseased Kindney
epithelial cells that line renal tubules are not actively engaged in proliferation

Cells begin to divide rapidly
Formation of epithelial and fluid filled cyts
Cystic cells contain a high level of Glycosphingolipids in their membranes
Glucose to ceramide
Increase in synthesis of glucosylceramide in cystic cells
Increase in cell proliferation and apoptosis

Malak Kourani

1st hour
ap bio
Ms.Fahs
Full transcript