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Transcript of psy383_Nicotine?
a behavior so ubiquitous, its name invokes an entire route of administration...
monoamine oxidase inhibitor:
also act(s) as
but this is complicated...
Perhaps more widely known as a key ingredient in...
prevents breakdown of orally
and many more!
increase availability of:
increases permeability to:
found both pre- & post-synaptically!
remember, there are no side-effects...
tobacco smoke inhaled
solid particulate matter (combusted)
substances in vapor form
abosrbed via lungs
lungs are like a giant mucous membrane from
which drugs can pass into the bloodstream
distributed via circulation
the heart pumps drug-containing blood from the lungs
throughout the body, including to our old friend, the brain
crosses the blood-brain barrier
a network of capillaries and astrocytes (glia) that selectively allows some substances to pass into the neural soup
Macusi (Guyana) word for blowdart poison
how would this kill you?
40 - 60 mg/kg
w/ relaxing properties?!
rats do not self-administer nicotine!!!
Guillem K, Vouillac C, Azar MR, et al. (September 2005). "Monoamine oxidase inhibition dramatically increases the motivation to self-administer nicotine in rats". J. Neurosci. 25 (38): 8593–600. doi:10.1523/JNEUROSCI.2139-05.2005. PMID 16177026.
widely regarded as one of the most addictive drugs
self-administration in animal models is our principle criterion for determining how dependence-inducing a substance is
binds to nicotinic receptor
ionotropic (fast neurotransmission)
non-selective cation channel
most common vehicle
fortunately, tobacco contains LOTS of drugs!
1. synthesized from choline and acetyl coenzyme A
2. packaged into vesicles via ACh transporter
3. released into synapse (when calcium enters cell)
4. 'extra' ACh is broken down by acetylcholinesterase
5. choline transporter reuptakes choline
contains ~ 1-3 mg nicotine
so WHY is it addictive?
can alter perception of:
"ripples in the stream of consciousness..."