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psy383_Nicotine?

Smoked tobacco: from cigarette to synapse
by

Will Moore

on 22 February 2016

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Transcript of psy383_Nicotine?

filter: 95% cellulose acetate
rolling paper
'tipping' paper
blended
shredded
tobacco
Nicotine
Na
K
Ca
+
+
+
+
inhibitory
excitatory
modulatory
Smoking:
a behavior so ubiquitous, its name invokes an entire route of administration...
Harmala Alkaloids
MAOI
monoamine oxidase inhibitor:
5-HT
NE
DA
harmaline
harmine
benzodiazepine site
inverse agonist
also act(s) as
but this is complicated...
Perhaps more widely known as a key ingredient in...
Ayahuasca
mood
prevents breakdown of orally
ingested
DMT
downstream
consequence:
and many more!
increase availability of:
increases permeability to:
found both pre- & post-synaptically!
remember, there are no side-effects...
only effects
1.
2.
4.
tobacco smoke inhaled
solid particulate matter (combusted)
substances in vapor form
abosrbed via lungs
lungs are like a giant mucous membrane from
which drugs can pass into the bloodstream
3.
distributed via circulation
the heart pumps drug-containing blood from the lungs
throughout the body, including to our old friend, the brain
crosses the blood-brain barrier
a network of capillaries and astrocytes (glia) that selectively allows some substances to pass into the neural soup
strychnos toxifera
curare
arrow poison
muscle relaxant
(rarely used)
wurari:
Macusi (Guyana) word for blowdart poison
how would this kill you?
source
half life:
LD :
50
40 - 60 mg/kg
human
2 hr
cholinergic stimulant...
w/ relaxing properties?!
rats do not self-administer nicotine!!!
Guillem K, Vouillac C, Azar MR, et al. (September 2005). "Monoamine oxidase inhibition dramatically increases the motivation to self-administer nicotine in rats". J. Neurosci. 25 (38): 8593–600. doi:10.1523/JNEUROSCI.2139-05.2005. PMID 16177026.
widely regarded as one of the most addictive drugs
self-administration in animal models is our principle criterion for determining how dependence-inducing a substance is
5.
binds to nicotinic receptor
ionotropic (fast neurotransmission)

non-selective cation channel
0.
cigarette:
most common vehicle
fortunately, tobacco contains LOTS of drugs!
Acetylcholine

cycle
1. synthesized from choline and acetyl coenzyme A

2. packaged into vesicles via ACh transporter

3. released into synapse (when calcium enters cell)

4. 'extra' ACh is broken down by acetylcholinesterase

5. choline transporter reuptakes choline
contains ~ 1-3 mg nicotine
so WHY is it addictive?
vision
audition
can alter perception of:
spacetime
"ripples in the stream of consciousness..."
synergistic potentiation
Full transcript