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Renin-Angiotensin-Aldosterone System (RAAS)

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Sumanpreet Dosanjh

on 9 December 2013

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Transcript of Renin-Angiotensin-Aldosterone System (RAAS)

Effect(RENIN)
What is controlled?
What is being controlled is blood pressure not only in the kidneys, but in the body as a whole.

Angiotensin increases blood pressure by four main ways:
1. It elevates local blood pressure in the glomerular capillaries by constricting efferent renal arterioles.
2. It elevates blood pressure throughout the body by constricting peripheral blood vessels all over the body.
3. It stimulates thirst. When water intake increases, blood volume increases and, therefore, blood pressure increases.
4. It stimulates the adrenal cortex to release the steroid hormone aldosterone.
Effect(Angiotensin)
When renin is released by the kidneys into the blood, it with another enzyme called ACE(angiotensin converting enzyme) converts an inactive protein form of angiotensin in the blood into the active hormone angiotensin.

For Renin, the target tissue is blood.

For Angiotensin, the target tissues are the renal arterioles, peripheral blood vessels, and adrenal cortex.

For Aldosterone, the target tissue is the kidney where it stimulates Na+ reabsorption.

Target tissue
The release origin is different for each of the two hormones and the one enzyme of the system:
For Renin(the enzyme), the release origin is the kidney.
Angiotensin’s (a hormone) release origin is the blood.
Release Origin
Kidney
Renin-Angiotensin-Aldosterone System (RAAS)
The RAAS system is a system that raises blood pressure in both kidneys and the body as a whole.

What is RAAS? Good question.
Aldosterone’s(the other hormone)
release origin is the adrenal gland.


Release Origin
Aldosterone stimulates Na+ reabsorption by kidneys.
It carries out this task by simulating Na+ reabsorption, which causes water reabsorption and this increases blood volume, therefore, increases blood pressure.

Effect(ALDOSTERONE)
Question: What type of system is it?
A. Antagonistic
B. Synergistic
C. Neither

B. Synergistic
GOOD JOB!!!!
The RAAS system is synergistic because renin, angiotensin, and aldosterone work together to cause changes that increase blood pressure.

WE’re almost done! Is the RAAS system animal or plant hormones?
The RAAS system is an animal hormone-based system.
THE END!!!!!!!!

sources
M. Hills, David; Sadava, David; Heller, Craig H.; V. Price, Mary. “Principles of Life.” Chapter 40: Salt and Water Balance and Nitrogen Excretion. Copyright 2012 by Sinauer Associates, Inc, 23 Plumtree Road, Sunderland MA 01375 USA.

M. Hills, David; Sadava, David; Heller, Craig H.; V. Price, Mary. “Principles of Life.” Chapter 40: Salt and Water Balance and Nitrogen Excretion. Copyright 2012 by Sinauer Associates, Inc, 23 Plumtree Road, Sunderland MA 01375 USA.
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