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Transcript of Goblet Cells
Common Name: Goblet Cell
Goblet cells are specialized epithelial cells, meaning they are found in the epithelial tissue. These cells are located along the outer linings of organs, including the intestinal and respiratory tracts. Goblet cells are also found inside the trachea, bronchus, small intestines, the colon, and in the upper eyelid. The concentration of goblet cells varies throughout the body; their numbers are small relative to other cell types, however in tissues such as the colon they are much more abundant.
The function of goblet cells is to secrete fundamental parts of mucus called mucins. These mucins are glycosylated proteins that are suspended in electrolytes. The mucus secreted by goblet cells are very important; mucus protects the body from chemical damage, and also helps to eliminate particles and microorganisms from the respiratory tree.
Secretion of mucus from goblet cells are induced by irritating stimuli rather than by hormones. The intestinal tract contains many irritants that provoke mucus secretion, and smoke and dust also induce secretion through goblet cells.
Two Methods of Secretion
1. Constitutive/Basal Secretion: low level, continuous secretion that is dependent upon cytoskeletal movement of granules.
2. Stimulated Secretion: regular excretion of granules in response to outer stimuli. This method allows for dramatically increased mucus secretion.
Like most cells, goblet cells have all of the common organelles. However, because these cells deal with secretion, the organelles of the secretory pathway are the central and most important organelles. These organelles include the rough endoplasmic reticulum, the Golgi body, and secretory vesicles.
What makes it different
March 20th, 2014
Biology 12, Block A
The structure of goblet cells is quite different when compared to other cells. Goblet cells have a narrow base where most organelles including the nucleus are found. These cells have a large apical section where mucus secreting granules are found. These cells look goblet shaped when viewed on slides, giving them their name. However, when the granules aren't expanded while preparing a slide, these cells look like simple column-like cells.
Goblet cells in small intestine
Goblet cells have adapted to their function by having a distinct goblet shape that allows mucus to be produced more effectively. Also, these cells have certain enzymes that engulf foreign particles.
Epithelial cells, the type of cell goblet cells are, differ from other cells in many ways. These types of cells are only found in the linings of the major cavities of the body. Also, epithelial cells are held more tightly together than other types of cells, allowing them to create a closed barrier to the external environment. Also, neuron endings are found in epithelial cell tissue. This allows for these cells to perceive external stimulus.