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Will Moore

on 10 February 2013

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Transcript of psy383_intro

Dr. Alan Leshner "Science must replace ideology as the foundation for drug abuse and addiction prevention, treatment, and policy strategies." "There is a unique disconnect between the scientific
facts and the public's perception about drug abuse
and addiction. If we are going to make any progress,
we need to overcome the 'great disconnect.' " "We have become convinved that contemporary efforts to educate people about the effects of alcohol and other drugs are inadequate and misdirected."

-Buzzed, p.17 "Every time a new brain circuit or a new neurochemical is discovered, that discovery provides an opportunity to develop drugs that alter brain function in a new way."
-Buzzed, p.18 "Good drug education requires a lot of effort. The scientific and medical literature is often difficult for most people to find and even more difficult to understand. Most interpretations of this literature to the general public are oversimplified, inaccurate, or disseminated by organizations that slant the research to further political and moral agendas."

-Buzzed, p.19 All-American at U of Maryland

2nd pick in 1986 NBA Draft

Died of cardiac arrhythmia
induced by cocaine overdose Len Bias: more than just a ghost story: "The Len Bias Law" Anti-Drug Abuse Act of 1988

Decreased mass requirements for mandatory minimum sentences:

Dealers who supply an overdose can be charged with homicide Fair Sentencing Act of 2010 Act of Congress signed into law by U.S. President Barack Obama on August 3, 2010.

The law reduced the disparity between the amount of crack cocaine and powder cocaine needed to trigger certain United States federal criminal penalties from a 100:1 weight ratio to an 18:1 weight ratio and...

eliminated the five-year mandatory minimum sentence for simple possession of crack cocaine, among other provisions. an inclination to present or hold a partial perspective at the expense of
(possibly equally valid) alternatives Drugs Kill: an effective deterrent? Not comprehensive Buzzed: Cons Promotes 'less bad' myths? Actively dispels several bad myths Riddled with 'I'm a cool Dad'-ism YOU are the target audience Alternate Agenda? Explicit Agenda: Eductation Accessible Buzzed: Pros Grades No surfing: Don't check your email

Don't get on Facebook

Don't get caught!!! SILENCE
your phone before class

(under any circumstances) No phones: No talking: Not even whispering

Feel free to ask questions
by raising your hand Instructor William Everett Moore III, M.S.
118 LISB How will you decide
what to believe
about drugs? Psychoactive Drugs ideology a set of ideas that constitutes one's goals, expectations, and actions. An ideology can be thought of as a comprehensive vision, as a way of looking at things (compare worldview), as in common sense (see Ideology in everyday society below) and several philosophical tendencies (see Political ideologies), or a set of ideas proposed by the dominant class of a society to all members of this society (a "received consciousness" or product of socialization). The main purpose behind an ideology is to offer either change in society, or adherence to a set of ideals where conformity already exists, through a normative thought process. Ideologies are systems of abstract thought applied to public matters and thus make this concept central to politics. Implicitly every political or economic tendency entails an ideology whether or not it is propounded as an explicit system of thought. It is how society sees things. science a systematic enterprise that builds and organizes knowledge in the form of testable explanations and predictions about the universe Buzzed Asks: former head of NIDA http://www.fbi.gov/stats-services/publications/law-enforcement-bulletin/2009-pdfs/april09leb.pdf Buzzed correctly points out that using scare tactics
like reminding people of Len Bias's overdose is a poor means of educating them about drugs. What it fails to address, however, is how central the events surrounding Len Bias's overdose were in shaping publicly funded drug education for the next 35 years... 5 grams, crack 500 grams, cocaine
(half this brick) Culture Politics Mechanisms Law History Economics (how drugs work) what Buzzed doesn't tell you... chemical substances that alter mood or behavior as a result of alterations in the functioning of the brain "In science a beginner will certainly read or be told "The scientist this" or "The scientist that." Let him not believe it. There is no such person as the scientist... Scientists are perople of very dissimilar temperaments doing different things in very different ways. Among scientists are collectors, classifiers and compulsive tidiers-up; many are detectives by temperamanet and many are explorers; some are artists and others are artisans. There are poet-scientists and philosopher-scientists and even a few mystics. What sort of mind or temperament can all these people be supposed to have in common? Obligative scientists are very rare, and most people who are in fact scientists could easily have been something else instead."
- P.B. Medawar Is your information biased? Mondays: 10:00am - 12:00pm Midterm: 30%

Final: 30%

Buzzkills: 30%

Participation: 10% Multiple Choice x 60 Multiple Choice x 60 ~150 words

2 sources > = x 5 attendance, engagement, in-class activities Rules Psychology 383: MW, 8:30 - 9:50am Effects (what drugs do) PATIENT Industry or Inquiry? cocaine receptor type low-potency /
partial agonists antagonists receptor location D 1 D 2 dopamine receptors post-synaptic
'excitatory' decrease cAMP increase cAMP pre- & post-synaptic
'inhibitory' family family what sort of drugs are these? downstream
effect dopamine methylphenidate Ritalin
(methylphenidate) ventral tegmental area (VTA) substantia nigra (SN) cocaine:
scientific 'facts' Dopaminergic (DA) Neuron Synaptic Action Route of Administration Psychomotor Stimulant

Half Life: ~50 min.

Low Dose: ~25-75 mg

Acutely Toxic Dose: 2mg/kg Serotonin Reuptake Transporter Dopamine Reuptake Transporter unecessary for
self-administration NECESSARY for
self-administration Drug Absorbtion (Thomsen et al., 2009) "Every time a new brain circuit or a new neurochemical is discovered, that discovery provides an opportunity to develop drugs that alter brain function in a new way."
-Buzzed, p.18 Pope Leo XIII: openly endorsed use of Vin Mariani
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