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Transcript of Hemophilia
-Bleeding in the mouth from a cut or bite or from cutting or losing a tooth
-Nosebleeds for no obvious reason
-Heavy bleeding from a minor cut
-Bleeding from a cut that resumes after stopping for a short time
-Signs of internal bleeding may include:
-Blood in the urine
-Blood in the stool
Bleeding in the Joints:
-Bleeding in the knees, elbows, or other joints is another common form of internal bleeding in people who have hemophilia. This bleeding can occur without obvious injury.
-At first, the bleeding causes tightness in the joint with no real pain or any visible signs of -bleeding. The joint then becomes swollen, hot to touch, and painful to bend.
-Swelling continues as bleeding continues. Eventually, movement in the joint is temporarily lost.
-Pain can be severe. Joint bleeding that isn't treated quickly can damage the joint
Bleeding in the Brain:
-Long-lasting, painful headaches or neck pain or stiffness
-Sleepiness or changes in behavior
-Sudden weakness or clumsiness of the arms or legs or problems walking
-Convulsions or seizures Hemophilia Facts It is passed on from mother to son, or her daughter could be a carrier of the disease. This disease is recessive. Hemophilia is located on the X chromosome. This disorder is not more likely to occur in certain populations. There are no environmental factors or influences. Most often, hemophilia is diagnosed after a person has an abnormal bleeding episode or when there is a known family history of the condition. A mother might be a carrier of hemophilia and then pass it on to her son, or her daughter might be a carrier. Hemophilia is sex-linked. It is a mutation and it is due to heredity. Treatment Standard treatment involves replacing the missing clotting factor through a vein (intravenous infusions). Scientists remove cells from the person with hemophilia (usually liver cells, but other cells have worked before) The scientist the genetically alters the cells by inserting new genetic material that reprograms the cell. The new genetic material instructs the cells to produce factor 8 or 9. The new cell is then reinserted into the person with hemophilia and then they no longer have hemophilia. Sources www.biogenidechemophilia.com