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The elderly gut microbiota

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by

Merle van Cranenbroek

on 23 January 2015

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Transcript of The elderly gut microbiota

What determines microbiota composition of elderly subjects?
What are the main microbiota differences between young and old individuals?
What is meant by inflammaging?
The microbiota in infants is highly dynamic
Change in:
diet
Low-grade chronic form of inflammation
reduced intestinal motility
reduced dentition
reduced salivary function
reduced chewing strength
increased intestinal permeability
The elderly gut microbiota
Based on the article of Claesson et al. 'Gut microbiota composition correlates with diet and health in the elderly' 2012
Thank you for your attention!
Risk for the elderly:
Sources:
Senescence of cells
damaged cells
harmful product of microbiota
Potential inflammatory diseases:
Alzheimer
bowel diseases
obesity
Diabetes Mellitus (type II)
Firmicutes most dominant in young adults
residence location
Composition destabilizes again in elderly
Decrease in abundance of firmicutes in elderly
lifestyle
intrinsic factors involved in eating and digestion:
possibly also: climate, culture and extreme environment
Full transcript