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Pulmonary Arterial Hypertension

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by

Yanbo Liu

on 8 January 2013

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Transcript of Pulmonary Arterial Hypertension

Pulmonary Arterial Hypertension Pulmonary Hypertension PAH
PH due to left heart disease
PH due to lung diseases / Hypoxia
Chronic thromboembolic PH
PH with unclear / multifactorial mechanisms pathological lesions affect the distal pulmonary arteries in particular.

medial hypertrophy,
intimal proliferative and
fibrotic changes
entitial thickening with moderate perivascular inflammatory infiltrates
complex lesions
thrombotic lesions.

Pulmonary veins are classically unaffected. Pathology Patience Affection Humanity Presented by Yi Zhou

Team of Yianzhu Liu, Xiuhui Ye, Yang Sun and Yanbo Liu Clinical Menifestations Symptoms
Early
breathlessness
Syncope
Late
Respiratory Failure
Right Heart Failure accentuated P2
murmur of tricuspid regurgitation
Jugular vein distension
hepatomegaly
peripheral oedema
cool extremities Lab & Auxiliary Examinations USG
Right heart catheterization / vasoreactivity
6-MWT
Pulmonary Function Tests
Blood tests and immunology Treatment General measures / Supportive therapy
Specific drug therapy
Oral anticoagulants - Wafarin INR 2.0
Treatment of Arrythmia
Balloon atrial septostomy
Transplantation Prognosis 2yr survival rate: 66%
5yr: 48% PAH assessed by right heart catheterization
mPAP>=25 mmHg
PCWC<=15 mmHg non-specific Patience Affection Humanity Presented by Yi Zhou

Team of Yianzhu Liu, Xiuhui Ye, Yang Sun and Yanbo Liu References
[1] Hoeper MM, Ghofrani HA, Gorenflo M, Grünig E, Schranz D, Rosenkranz S; European Society of Cardiology (ESC) und European Respiratory Society (ERS).
[2] Diagnosis and management of pulmonary arterial hypertension ACCP evidence—based clinical practice guidelines Chest2004, 126(Suppl 1) lS_92S SPAP=4V2+RAP Thank You!
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