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Palmitoylethanolamide in ulcerative colitis

PEA can counteract inflammatory signals in mice and humans, representing a novel and potential pharmacological tool to modulate inflammation during ulcerative colitis and Crohn
by

jan keppel hesselink

on 16 August 2014

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Transcript of Palmitoylethanolamide in ulcerative colitis

Palmitoylethanolamide in ulcerative colitis
In colitis ulcerosa the gut tissue tries to counteract
the chronic inflammation by the synthesis of
palmitoylethanolamide
This was described in a 2013 paper from
the university of Rome (It) and Harvard (USA)
They measured palmitoylethanolamide levels in the gut tissue
of patients suffering from colitus ulcerosa and of a mouse model of colitis
In the graph we clearly see the differences in PEA content
in diseased tissue compared to healthy tissue: the right hand is human tissue and patient tissue; the left hand depicts the animal model tissue levels
PEA in its pure form, given orally (10-30 mg/kg BW) dose-dependentlyinhibited the symptoms of colitis,
bloody stool and inhibited
significantly a multitude of inflammatory parameters!
Full transcript