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EP 2014 04 Biotech CLOSING No 5 v1

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Raymond McCauley

on 18 April 2014

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Transcript of EP 2014 04 Biotech CLOSING No 5 v1

Singularity
University

for your attention
raymond@raymondmccauley.net
Biology now falls under Moore's Law
Raymond McCauley
biochemistry
biophysics
electrical engineering
computer science
bioinformatics
nanotechnology
genetic engineering
DNA sequencing
personalized health
DISCLAIMER
These are my opinions and are not intended to reflect the views of any group or organization with which I may be affiliated.
DNA Sequencing Economics
Cost
Exponential Biosciences
systems
biology
DNA Sequencing Tech 5X ~ 10X

Computer Tech
1.5X ~ 2X
past:
Biotech Chair: Singularity U
Co-Founder: Playtpus Project
Co-Founder & Chief Architect: BioCurious
Principal: Exponential Biosciences

Current Research Areas:
Personal Genomics
Low Cost Access to Biotech Tools
Genetic Engineering
Cancer Sequencing
Companies to Watch
Illumina
Complete Genomics
Ion Torrent / Life Technologies
Oxford Nanopore
Genia
DNAnexus
Invitae
NuMedii
Personalis
Station X *
Strand LS
SV Bio
Genentech
Genomic Health
Counsyl
Vecoy Nanomedicines
Verinata **
Second Genome
Next Gen Sequencing
Next Next Gen Sequencing
Informatics
Diagnostics/Treatment
& a Garage Near You...
Genetic Engineering
Innovation Lessons
from being in
an exponential business
Find an exponential trend,
then hitchhike
A prototype beats a plan
Product Development Process (PDP)
typical product:
18 month development cycle,
9 month market life

make new & rev old products
core team leaders involved from start
phase-gated milestones
manage technical and business risk
New Developments
Nothing fades faster than last year's technology
2008
$500K
Today
$1
Closing Thoughts
In the future,
if it is made out of
atoms,

you will make it with
biology.
What does your industry
make or use?
DNA Origami
Genetic Engineering
Industrial
Human
Food
PGD
mitochondrial therapy
germ line therapy
"Redneck Genetic Engineering"

bone marrow replacement
HIV cure
Nic Volker cure
Gene doping
"
The GM debate is over...
We no longer need to discuss whether or not it is safe — over a decade and a half with three trillion GM meals eaten, there has never been a single substantiated case of harm.
You are more likely to get hit by an asteroid than to get hurt by GM food.”
- Mark Lynas, GMO crop burning environmental activist
"...There is no more risk
in GMO food than conventionally
farmed food."
- Anne Glover,
European Commission’s
Chief Scientific Advisor
Digital Agriculture
versus
Digital Agriculture
Okanagan Specialty Fruits
Aqua Bounty
Arcadia BioSciences
Species Conservation
Scientist seeks
"adventurous
human woman"
to have
Neanderthal baby
:(
:)
Singularity
University
or need to unmake?
What's Next
People
Teams
Interdisciplinary
Innovation Lessons
from being in
an exponential business
Find an exponential trend,
then hitchhike
A prototype beats a plan
Product Development Process (PDP)
typical product:
18 month development cycle,
9 month market life

make new & rev old products
core team leaders involved from start
phase-gated milestones
manage technical and business risk
Nothing fades faster than last year's technology
2008
$500K
Today
$1
People
Teams
Interdisciplinary
=
DNA sequencing
and synthesis prices
continue to plummet
Synthetic
Biology
*
Hype Cycle
but...
Metagenomics
Meta
Raymond McCauley
@raymondmccauley
+1-650-776-4561
Thank you
Peter DiLaura
Second Genome
New Yorker article
DNA has 521 year half-life
GMO
Anxiously watching
IP
Hopefully watching
Crowdfunding
Watching in
rearview mirror
Regulatory
Covers
Disease risk, carrier status,
genealogy, random stuff

What do
you
want to know?
Some of your info also applies to
family...

Privacy:
to share or not to share?
Do you want to be found by long-lost relatives?
Health insurance
protected by law

(GINA)
Life insurance, long-term disability is
not
Human
Prenatal Genetic Dx
Mitochondrial therapy
Germ line therapy
"Redneck Genetic Engineering"

bone marrow replacement
HIV cure
Nic Volker cure
Gene doping
How long until
genetic engineering
for
humans
?
How long until
genetic engineering
for
adults
?
Do you
believe?
Looking for innovation in biotech?
Look in a garage near you...
Food & Synthetic Biology
Sample6
Modern Meadows *
Evolva
Raymond McCauley
Digital Biology:
The Reckoning
Future
of genetic engineering
raymond@raymondmccauley.net
@raymondmccauley
Timothy Ray Brown
HIV diagnosed 1995
AML diagnosed 2006
CCR5Δ32 stem cell transplant
HIV-free since 2009
Blood, March 10, 2011, vol. 117, no. 10, 2791-2799
Photo: Peter Rigaud, for Stern, 2010
The Sugarbelt Bioeconomy
What areas of the world will
drive a green bioeconomy?
x
x
Land prices,
Political stability
Water access
Sunlight access
Argentina
Brazil
Uruguay
=
The Sugar Economy
What areas of the world will
drive a green bioeconomy?
x
x
Land prices,
Political stability
Water access
Sunlight access
Argentina
Brazil
Uruguay
=
Synthetic Biology Explained
James Hudson/Bridge 8
Video
6 min 27 sec (partial)
for now
ZFPs
TALENs
CRISPR
$10000
$5000
$1000
Better, Cheaper, Faster
Genetic Engineering Tools
*
The
small
future
is
industrial microbiology
"Mary had a little microbe"?
gene prospecting
Drag and Drop
Genetic Engineering
TALENs
Transcription
Activator
Like
Effector
Nucleases
TALENs have modified genes in:
yeast
fruitfly
roundworm
cricket
zebrafish
frog
rat
pig
cow
thale cress
rice
silkworm
human somatic cells
pluripotent stem cells
Nature Reviews Molecular Cell Biology 14, 49-55 (January 2013)
http://www.brc.a-star.edu.sg/index.php?sectionID=12
hijacked from plant bacteria that genetically engineer their host plants
discovered by Bogdanove & Moscou, Iowa State University, in 2009
make double stranded breaks to knock-out and knock-in genes
Clustered
Regularly
Interspaced
Short
Palindromic
Repeats
hijacked prokaryotic immune system mechanism
discovered by Horvath & Barrangou, DuPont/Danisco, in 2010
immunize industrial bacteria
gene silencing in stem cells
CRISPRs
MSTN
LRP5
APP
CCR5
PCSK9
FUT2
Lean muscles
Extra-strong bones
Alzheimer’s-resistant
HIV-resistant
Lower coronary risk
Stomach flu resistant
Genes to Knock Out
adapted from George Church, private communication
Behavioral and Mental Traits
MAOA gene & aggression
last to implement
poorly understood
Therapeutics,
then
Enhancement
Gene Expression
"gene doping"
EPO, red blood cell production
Myostatin, muscle growth inhibition
VEGF, blood vessel production
IGF-1, targeted muscle mass increase
Qualified
Speculation
RNA-Guided Human Genome Engineering via Cas9
Prashant Mali, Luhan Yang, Kevin M. Esvelt, John Aach, Marc Guell, James E. DiCarlo, Julie E. Norville, and George M. Church
Science 15 February 2013

Multiplex Genome Engineering Using CRISPR/Cas Systems
Le Cong, F. Ann Ran, David Cox, Shuailiang Lin, Robert Barretto, Naomi Habib, Patrick D. Hsu, Xuebing Wu, Wenyan Jiang, Luciano A. Marraffini, and Feng Zhang
Science 15 February 2013
Academically (for reference)...
Commerically...
$43 million Series A , Nov 2013
Flagship Ventures
Polaris Partners
Third Rock Ventures
Partners Innovation Fund
TALENs
CRISPRs
The
future
is
coming
fast
DNA Scan
DNA Sequence
most interesting/best known
1.2 million bases
0.04%
almost all
3.2 billion bases
100%
Peter DiLaura, CEO
Practical Advice
Use antibiotics wisely
Eat like ancestors
Get a dog

Covers
Disease risk, carrier status, genealogy

What do
you
want to know?
Some of your info also applies to
family...

Privacy:
to share or not to share?
Do you want to be found by long-lost relatives?
In US,
Health insurance
protected by law

(GINA)
Life insurance, long-term disability is
not
FFPE
FF
Formalin Fixed
Paraffin Embedded
Fresh
Frozen
versus
This could save your life...
from Eric Topol, MD
STATION
Clinical Genetics
Cancer Genetics
Software for
Good place to pause
& take a breath...
Embrace genetic info
for preventive health
Encourage gene scans in corporate wellness programs
Insurance changes forever
in the biotech 21st century
Absolute
Privacy , Data
Escrow
good preview
of things to come
Try it
Best Conference
Future of Genomic Medicine
Dr. Eric Topol, Scripps Health
March 6&7 2014
Clinicians - Keep Learning
Drag & Drop Tools
DNA Synthesis
Lab Automation
Systems Biology
TALENs & CRISPRs
Renaissance in
Genetic Engineering
Industry Materials Energy Agriculture Medicine Research
Basic Research
Always Pays Off
Mitacs Accelerate's research internship program
NRC’s Industrial Research Assistance Program
CRA's Scientific Research and Experimental Development Tax Incentive
Gov't & Industry Cooperation in Canada
Drag & Drop Tools
DNA Synthesis
Lab Automation
Systems Biology
TALENs & CRISPRs
Renaissance in
Genetic Engineering
Industry Materials Energy Agriculture Medicine Research
Basic Research
Always Pays Off
Mitacs Accelerate's research internship program
NRC’s Industrial Research Assistance Program
CRA's Scientific Research and Experimental Development Tax Incentive
Gov't & Industry Cooperation in Canada
Raymond McCauley
Biotechnology
raymond@raymondmccauley.net
@raymondmccauley
Foundation Medicine
FoundationOne Test Video
2 min 18 sec
Cancer
Microbiome
Get-around-the-FDA hack
Raw Data
Demo:
Anyone want to share?
Sleep
Take Your Medicine!
Reminders
Keepers
Sleep
Aid
Wake
Aid
Are you a fast caffeine metabolizer?
Reproduction
Standing
Desks
Resources
10% Solution
Live Long Enough to Live Forever
Quantified Self Gadgets
Hacker's Diet
SNP ID: rs762551
AA = Fast
AC = Slow
CC = Slow
orange glasses
daylight spectrum
sleep monitors
"no glowing rectangles"
sleep hygiene
Supplements
If you take just
3 supplements a day...
Multivitamin & mineral supplement
Omega-3 fatty acids (EPA & DHA),
Enteric
Vitamin D
If you take a 4th one...
Coenzyme Q10
antioxidant
If you take a 5th one...
Phosphatidylcholine
skin membrane component
Drugs
Use pharmacogenomics
B9 vitamin levels
& MTHFR gene
Test,
Then Take
Wired Profile: Secrets of My DNA
Weight
Exercise
Lifestyle
Hacking
Change, Measure, Repeat
Test,
Then Take,
Then Test Again
Blood
Testing
DNA
Testing
Crossover Study
Get a Baseline
Things that work on average
don't always work for individuals
Skepticism
Resources
Your Turn
Diet
lots of opinions...
food scale
genomics, not yet...
What tools can people use
to get better health and longevity?

Not in 10 or 20 years
But now
IANAD
I AM NOT
A DOCTOR
Most of the tools
we talk about
and would like to have
are still in early stages...
Not medical advice
Consult your doctor
My personal opinions
Please don't sue me...
We have
great
doctors...
Daniel Kraft
Catherine Mohr
Peter Diamandis
Dan Barry
But I do some things differently,
today
,
because of the technologies I know about
and the lessons I've learned...
Go to your doctor
Eat Less
Exercise More
Little things &
Things you already know
Get genetic testing,
Do advanced tests,
Apply AI diagnostics
Eat Less
Exercise More
But you really do it!
NOT
NOT
Get Sequenced Today?
Rare Disease
Hereditary Disorder
Cancer
Research
=YES
Personalized Medicine = What works for
you
Crowd Sourced
Clinical Trials
Intervention
Compliance
Eat
Less
Workout
More
>
Metagenomics
Cancer
Eliminate
Antibiotic-Treated
Meat
Clinical Genetics
STATION
Cancer Genetics
Interpretation for
solid tumor cancers
hematologic cancers
sarcomas
pediatric cancers
breast cancer
colon cancer
prostate cancer
oncology research
weight genomics
+
quantified self
+
motivation
BIG
DEAL
IVF - in vitro fertilization
PGD - prenatal genomic diagnosis
egg and zygote storage
genomic karyotyping (Verinata)

hormone replacement therapy
(except in some cases)

And... Prizes!
?
Drag & Drop Tools
DNA Synthesis
Lab Automation
Systems Biology
TALENs & CRISPRs
Renaissance in
Genetic Engineering
Industry Materials Energy Agriculture Medicine Research
FFPE
FF
Formalin Fixed
Paraffin Embedded
Fresh
Frozen
versus
Got cancer?
This could save your life...
from Eric Topol, MD
Eliminate
Antibiotic-Treated
Meat
Full transcript