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Zika Virus

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Greg Aguon

on 22 October 2015

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Transcript of Zika Virus

The virus was first isolated the Zika forest in Uganda, Africa in 1947
In a rhesus monkey.
In 1968, the first human case was isolated in Nigeria.
The Zika virus (ZIKV) is a member of the Flaviviridae virus family and the flavivirus genus. In humans, it causes a disease known as Zika fever. It is closely related to Spondweni virus. Other similar types of viruses include dengue, yellow fever, West Nile, and Japanese encephalitis.
Mild headaches
Maculopapular rash
Arthralgia
Common symptoms of the Zika virus are:
Fever
Malaise
Conjunctivitis
There is no vaccine or preventive drug for Zika virus, and only treatment of symptoms is possible.
Usually non-steroid anti-inflammatories and/or non-salicylic analgetics are used.
There are 6 elements in the Zika virus'
cycle of infection.
Portal of Entry
When biting a person for its blood meal, an infected mosquito releases saliva containing the Zika virus. Once in the body the virus infects the immune cells in the skin tissue and enters the lympatic system. The viral infection can then trigger a strong inflammatory reaction. During the incubation period the virus first replicated locally and then spreads into the blood stream of the infected person. This is called viremia.
In 2009, it was proved that the Zika virus can be sexually transmitted between humans. Professor Brian Foy was doing research in Senegal, South Africa to study mosquitos. He was bitten numerous times during his research. He returned to the U.S. and a few days later he fell ill with Zika, but not before having vaginal intercourse with his wife. His wife showed symptoms of Zika infection and sensitivity to light. Professor Foy is the first person known to have passed on an insect borne virus to another human by sexual intercourse.
Transmission of Disease
This disease is transmitted through vectors, which is an arthropod in whose body an infectious organism develops or multiplies before becoming infective to a new host. By biting another person it can transmit the virus and spread the disease.
It is transmitted by mosquitos also known as vectors and has been isolated from a number of species in the genus Aedes – Aedes aegypti specifically.
Reservoir of Infection
The Zika virus replicates itself in the cytoplasm of the susceptible host and also reproduces in the vectors. Here is where they thrive in sufficient numbers to pose a threat. An example of a reservoir would be a radiographer with an upper respiratory tract infection.
Zika Virus
Greg Aguon
RAD184
Susceptible Host
The most susceptible host are patients who have suppressed immune system, very young, and the very old. The non-immune are everyone who has not been previously exposed and generated a specific immune response to the Zika virus.

Portal of Exit
When a mosquito bites a person that’s already infected it draws in the virus contained in the blood.

The following video is about Dengue, which has the same cycle of infection as the
Zika virus.
Hope you enjoyed the show!
Pathogenic Organism
The Zika virus is capable of causing disease.
It possess certain virulence factors that distinguishs it from a non-pathogenic organisms or normal flora. These factors enable bacteria to destroy or damage host cells and resist destruction by the host's cellular defenses. They attach themselves to the host's cells excrete protein substances called toxins that can kill or injure the host cell.
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