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Human Aging

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Steven Leong

on 21 March 2014

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Transcript of Human Aging

Biological Factors in Aging
Human Aging

Biological definition of aging
progressive accumulation of molecular damage in nucleic acids, proteins and lipids
due to inefficiency and failure of maintenance of repair and turnover pathways
Sun Exposure
promotes wrinkles
production of freckles
discolored areas of skin
dilation of blood vessels under the skin
damages chromosomes in skin cells
severe damage can lead to cancers
Other environmental factors
Job related
exposed to toxins
particulates, asbestos (lungs)
chemical toxins (liver, kidney)
Person's surrounding area
Heavy metals: lead and mercury affected the brain
power plants - exposure to radiation
Lifestyle of the Individual
eating healthy, instead of poor
Physical Activity
exercising regularly
Poor decision making
use of alcohol or tobacco
not getting enough sleep
Key components:
Hyaluronic acid - retains moisture
Salicylic acid - exfoliater
Retinol - Vitamin A
Peptides - collagen synthesis

Reducing lines
Collagen production (cell turnover)
Home modifications:
Shower chairs
Hand rails
Wheel chairs
Wrist/hand supports
Hearing aids

Technology affecting Aging
Environment affects Aging
Chemical peel - causes old skin to peel off and new skin to be revealed
Laser resurfacing - removes age spots and uneven tones
Plastic surgery
Corrective surgery -LASIKS, PKR
Cataract surgery - artificial lens to replace old one
Glaucoma surgery - intraocular pressure
Hip/knee replacements
Pain relief
By: Kierra, Steven, and Farhan
Genetic influence
on aging
monozygotic twins have more similiar lifespan than heterozygotic twins
Genes account for only 25% of what determines the length of life
oxygen is a potent source for molecular damage
oxidative stress can influence the shortening rate of telomeres, which are linked with aging and cellular lifespan
DNA repair capability correlates with life span of species
some age associated diseases are due to biological aging rather than chronological
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