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AP Biology Research

Cell Signaling Diseases Project
by

Devany Guizar

on 9 November 2012

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Transcript of AP Biology Research

Chronic Myelogenous
Leukemia By Devany Guizar Leukemia Facts
According to the American Cancer Society, some 43,000 people in the United States are diagnosed with leukemia each year. This includes about:
15,000 cases of chronic lymphocytic leukemia (CLL), most in older adults
13,500 cases of acute myeloid leukemia (AML), most in adults
6,000 cases of acute lymphocytic leukemia (ALL), about one in three in adults
5,000 cases of chronic myeloid leukemia (CML), most in older adults Pictures What causes CML? CML Patients and Affected Organs http://www.intelligentdental.com/2012/04/15/dental-management-of-leukemia-patients/

http://www.differencebetween.net/science/health/difference-between-lymphoma-and-leukemia/

http://www.lightthenight.org/id/localchapter/patients

http://www.omnimedicalsearch.com/conditions-diseases/chronic-myelogenous-leukemia.html http://www.mayoclinic.com/health/chronic-myelogenous-leukemia/DS00564/DSECTION=symptoms

http://www.cancer.gov/cancertopics/pdq/treatment/CML/Patient/page4#Keypoint13

http://www.cancer.org/cancer/leukemia-chronicmyeloidcml/detailedguide/leukemia-chronic-myeloid-myelogenous-new-research

http://www.cancernetwork.com/chronic-myeloid-leukemia/content/article/10165/61348 Information Targeted therapy
Chemotherapy
Biologic therapy
High-dose chemotherapy with stem cell transplant
Donor lymphocyte infusion (DLI)
Surgery Treatments Chronic=being long-lasting and recurrent or characterized by long sufferingMyelogenous=Produced in bone marrowLeukemia=cancer of the bone marrow that prevents the normal manufacture of red and white blood cells Chronic=being long-lasting and recurrent or characterized by long suffering
Myelogenous=Produced in bone marrow
Leukemia=cancer of the bone marrow that prevents the normal manufacture of red and white blood cells Studies of chronic myeloid leukemia (CML) are being done in labs and in clinical trials around the world.
Scientists are making great progress in understanding how changes in a person's DNA can cause normal bone marrow cells to develop into leukemia cells. Learning about changes in the genes (regions of the DNA) involved in CML is providing insight into why these cells grow too quickly, live too long, and fail to develop into normal blood cells. The explosion of knowledge in recent years is being used to develop many new drugs.(imatinib, dasatinib, nilotinib, and bosutinib) What`s new in chronic myeloid leukemia research and treatment? It is caused by what is called the "Philadelphia Chromosome"a genetic mutation in which typically there is a chromosomal translocation between chromosomes 9 and 22
The Philadelphia chromosome creates a new gene called BCR-ABL. which contains instructions that tell the abnormal blood cell to produce too much of a protein called tyrosine kinase. Tyrosine kinase promotes cancer by allowing certain blood cells to grow out of control.
The diseased white blood cells don't grow and die like normal cells. The diseased white blood cells build up in huge numbers, crowding out healthy blood cells and damaging the bone marrow. Numerous signal transduction pathways, including Ras/Raf/mitogen activated protein kinase (MAPK), phosphatidylinositol 3 kinase, STAT5/Janus kinase, and Myc, are activated by the Bcr-Abl tyrosine kinase (Figure 1).[4,5] Perturbation of these pathways results in uncontrolled cell proliferation and reduced apoptosis.
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