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Transcript of Cushing's Syndrome
SYNDROME By, Tom Morin Symptoms Osteoperosis Hypertension "Buffalo Hump" "Moon Face" SOURCES http://www.nlm.nih.gov/medlineplus/ency/article/000410.htm Abdominal Obesity Excess Cortisol Muscle Weakness Striae (but with thin arms and legs) More Skin Conditions -Skin ulcers -Thin, wrinkled skin -Poor wound healing -Purpura CAUSE? Taking too many corticosteriod medications.
(commonly used to treat asthma
and rheumatoid arthritis) One Cause Another Cause Tumor:
-in the adrenal gland
-in an ACTH-producing area (lung, thyroid, pancreas)
-anywhere else in the body that produces cortisol Our Focus Excess production of ACTH
in the pituitary gland
(possible cause: tumor) Cortisol Feedback Loop Endocrine Neoplasia Rare, inherited genetic condition that causes cells of endocrine glands to grow uncontrollably MET1 RET 2 Mutated Genes Codes for menin (tumor supressor)
Location: Chromosome 11 Codes for a protein involved in cell signaling
Location:Chromosome 10 Too Much Cortisol? 1. Cortisol attaches to receptor
2. Receptor complex dissociates and dimerizes
3. Receptor and hormone are transported into the nucleus and bind with DNA
4. Transcription of genes for regulatory enzymes in the pathway of gluconeogenesis
5. Liver creates more glucose
One Example Cortisol Pathway:
These sorts of metabolic changes cause the physiological changes seen in Cushing's Syndrome. TREATMENTS - Removal of Tumor
- Radiation Therapy
(In above cases, patients must be put on temporary cortisol supplements)
- Lowered dosage of corticosteroids
(if cause was drugs) http://books.google.com/books?id=3FNYdShrCwIC&pg=PA178&lpg=PA178&dq=signal+transduction+pathway+of+cortisol&source=bl&ots=4A_216U1NH&sig=Lq8T_SM0wOUVUXI_r_HmUqwO20k&hl=en&sa=X&ei=GRflUNWHLYj-0gHZ1YG4Cw&ved=0CDoQ6AEwAQ#v=onepage&q=signal%20transduction%20pathway%20of%20cortisol&f=false http://ghr.nlm.nih.gov/condition/multiple-endocrine-neoplasia http://www.endocrine.niddk.nih.gov/pubs/cushings/cushings.aspx http://www.comprehensivephysiology.com/WileyCDA/CompPhysArticle/refId-cp070423.html