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Metabolic Pathway

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by

Rayne Salyers

on 18 December 2013

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Transcript of Metabolic Pathway

Citrate
Isocitrate
a-Ketoglutarate
Succinyl-CoA
Succinate
Fumarate
Malate
Oxaloacetate
TCA Cycle
H2O
Citrate synthase
CoASH
Acetyl CoA
Aconitase
NAD+
NADH+
CO2
Isocitrate
dehydrogenase
NAD+
NADH+
CO2
a-Ketoglutarate
dehydrogenase
CoASH
GDP
GTP
ADP
ATP
Nucleoside
diphosphate
kinase
P
Succinyl-CoA
synthetase
FAD
FADH2
Succinate
dehydrogenase
H2O
Fumarase
Malate
dehydrogenase
NAD+
NADH+
Pyruvate
CO2
CoASH
NAD+
NADH+ H+
Pyruvate dehydrogenase
Citrulline
Argininosuccinate
Arginine
Ornithine
Aspartate
ATP
AMP + PPi
Argininosuccinate
synthetase
Fumarate
Argininosuccinase
Arginase
Urea
Ornithine
transcarbamoylase
Carbamoyl-PO4
CO2
NAG
2 ATP
NH3
2ADP + Pi
Carbamoyl phosphate
synthetase
Glutamate
a-ketoglutarate
Alanine
Pyruvate
Urea Cycle
Glucose
Glucose-6-P
ATP
ADP
Fructose-6-P
Fructose 1,6 bis P
ATP
ADP
Glyceraldehyde-3-P
1, 3 bis P glycerate
NAD+
NADH+ H+
3-P glycerate
ADP
ATP
2-P glycerate
PEP
Pyruvate
Lactate
ADP
ATP
NAD+
NADH+ H+
DHAP
Fructose-1-P
Fructose
ATP
ADP
Glycolysis
Glucose-1-P
Galactose-1-P
Galactose
ATP
ADP
Phosphoglucomutase
Glucose
ATP
ADP
Glucosokinase/Hexokinase
Hexokinase
Glucose phosphate isomerase
Phosphofructokinase
Fructokinase
Fructose biphosphate aldolase
Triosephosphate isomerase
G-3-P dehydrogenase
Phosphoglycerate kinase
Phosphoglycerate mutase
Enolase
Phosphoenolpyruvate kinase
Lactate dehydrogenase
Cell Membrane
a-D-glucose
ATP
ADP
Hexokinase in muscle
Glucokinase in liver
Glucose-6-P
Phosphoglucomutase
Glucose-1-P
UTP
PPi
UDP-glucose
Glycogenin primer
Glycogen
(unbranched)
Glycogen
(branched)
Glycogen synthase
Branching
enzyme
Glycogenesis
Nonreducing end of
glycogen chain
HPO4 -2
Glycogen
phosphorylase
Glucose-1-P
Glucose-6-P
+ Residual
glycogen
chain
Pi
liver only
Glucose
Glycogenolysis
Glucose-6-P
6-phosphoglucono-lactone
NADP+
NADPH + H+
6-phosphogluconate
Gluconolactonase
D-ribulose 5-phosphate
NADP+
NADPH + H+
CO2
Fructose-6-P
Glyceraldehyde-3-P
Transketolase
Transaldolase
Transketolase
Reversible
D-ribose 5-P
D-xylulose 5-P
Epimerase
Phosphopentose
isomerase
Oxidative Stage
Nonoxidative Stage
Hexosemonophosphate
Shunt
(Pentose-phosphate
Pathway)

Glucose
G6P
F6P
FBP
DHAP
Glycerol
G3P
BPG
3PG
2PG
PEP
Oxaloacetate
Malate
Malate
Fumarate
Succinate
Succinyl-CoA
a-ketoglutarate
Amino
Acids
Oxaloacetate
Pyruvate
Pyruvate
Lactate
Gluconeogenesis
Before Fatty Acid Synthesis
Mitochondria
Acetyl-CoA + Oxaloacetate
Citrate
Citrate Synthetase
Movement of Acetyl-CoA to Cytosol
Citrate
CoA
ATP
ADP + Pi
Citrate
Lyase
Oxaloacetate + Acetyl-CoA
Formation of Malonyl CoA
Malonyl-CoA
CO2
ATP
ADP + Pi
Acetyl-CoA
carboxylase
"Loading" of sulfhydryl groups into the fatty acid synthase system
Acetyl-CoA + HS
Malonyl-CoA + HS
CE
ACP
Acetyl
Malonyl
CE
ACP
+ 2 SCoA
Fatty Acid Synthesis
CO2
NADPH(H+)
NADP+
H2O
NADPH(H+)
NADP+
CO2
HS
Fatty Acid
CE
ACP
B-ketoacyl-ACP synthase
B-ketoacyl-ACP reductase
B-hydroxyacyl-ACP dehydratase
Enoyl-ACP reductase
Repeated
Sequence
Fatty acid
ATP
AMP + PPi
CoA
Acyl-CoA synthetase
Fatty Acyl-CoA
Activation of a Fatty Acid
Activated Fatty Acyl-CoA
B-oxidation of Fatty Acid
Ketone Body
Formation

Acetyl-CoA
Acetyl-CoA
CoA
Acetoacetyl-CoA
CoA
Acetoacetate
Acetone
B-hydroxybutyrate
Extrahepatic
tissues
Glucose-Alanine Cycle
Liver
Pyruvate
Alanine
a-ketoglutarate
Glutamate
NH3
Urea
Muscle
Pyruvate
Alanine
a-ketoglutarate
Glutamate
Leucine
a-ketoisocaproate
Mitochondrion
Pyruvate carboxylase
Malate dehydrogenase
PEP carboxykinase
Primer Function of Glycogenin
nUDP-Glu
nUDP
Glucosyl
transferase
Glycogenin
Glu
Glu
Glu
Glu
Palmitoyl-CoA
FAD
FADH
Unsaturated acyl-CoA
Enoyl-CoA
H2O
B-hydroxyacyl-CoA
NAD+
NADH + H+
B-ketoacyl-CoA
CoA
Occurs in many tissues
Saturated CoA-activated
fatty acid + Acetyl-CoA
glucose-6-P
glucose-1-P
glucose-6-P
pyruvate
pyruvate
lactate
Ala
Gly
Trp
Ser
Cys
Thr
Acetyl-CoA
fatty acid
Acetyl-CoA
Acetyl-CoA
Arg
His
Pro
Glu
Gln
Val
Ile
Met
Thr
Phe
Tyr
Asp
Asp
Asn
Ile
Leu
Lys
Thr
Trp
Alanine
glucose
Pyruvate
Pyruvate
Oxaloacetate
Fumarate
CO2
Fatty Acyl-CoA
Glycogen
Glucose-6-P
Fructose-6-P
Phe
Leu
Tyr
CoA
TDP
NADH
Mg2+
Biotin
Oxaloacetate
Hexose phosphate isomerase
Phosphoglucomutase
Glucose-6-Phosphatase
(in liver or kidney)
Biotin
Glucose-6-Phosphatase
Fructose 1,6-biphosphatase
Pyruvate kinase
Malate
dehydrogenase
Lactate dehydrogenase
Mg2+
Mn
Mg2+
PLP
PLP
PLP
PLP
PLP
CoA, TDP, NADH, Mg2+
PLP
Biotin
PLP
PLP
PLP
CoA, TDP,
NADH, Mg2+
PLP
Pathway Reactions
Pathway Links
Enzymes
Hot Pink Font
KEY
Oxaloacetate
Metabolic Pathway

Rayne Salyers
Full transcript