Loading presentation...

Present Remotely

Send the link below via email or IM

Copy

Present to your audience

Start remote presentation

  • Invited audience members will follow you as you navigate and present
  • People invited to a presentation do not need a Prezi account
  • This link expires 10 minutes after you close the presentation
  • A maximum of 30 users can follow your presentation
  • Learn more about this feature in our knowledge base article

Do you really want to delete this prezi?

Neither you, nor the coeditors you shared it with will be able to recover it again.

DeleteCancel

SAK Family Mtg McCauley 2018 02

No description
by

Raymond McCauley

on 18 April 2018

Comments (0)

Please log in to add your comment.

Report abuse

Transcript of SAK Family Mtg McCauley 2018 02

Investment Syndicate
Hacking DNA for Fun and Profit
Raymond McCauley
@raymondmccauley +1-650-776-4561
+1-650-776-4561
for your attention
Raymond McCauley
biochemistry
biophysics
electrical eng.
computer science
bioinformatics
nanotechnology
DISCLAIMER
These are my opinions and are not intended to reflect the views of any group or organization with which I may be affiliated.
Exponential Biosciences
past:
Raymond McCauley
@raymondmccauley
Thank you
Conflicts
& Financial Interests
Anthrocyte
Deloitte
Exogen
Genomera
GLG
Illumina
Intellimed
Platypus Project
QIAGEN
Singularity University
Verinata
WellPoint
Marked with throughout presentation.
*
Entire presentation copyright 2014 by Raymond McCauley
advisor,
consultant,
investor
Raymond McCauley
raymondmccauley
on Google, LinkedIn & Twitter
+1-650-776-4561
Creative Commons
Attribution-NonCommercial
4.0 International
READING DNA
WRITING DNA
HACKING DNA
2013
=
2007
=
2015
=
+
2001
=
+
+
2018
2022
=
=
=
Source: National Human Genome Research Institute, Exponential Biosciences,
Aug 2017
$999 genome sequencing
$80 exome sequencing
+ interpretation
+ access to
app store
$199 BRCA testing
+ interpretation
+ counseling
+ updates
$29 superhero testing
+ scans variants for
strength
intelligence
speed
+ counseling
+ cape
for qualifying
individuals
veritasgenetics.com
getcolor.com
helix.com
orig3n.com
genomics
In the era of the
$1000 Genome
and racing toward the
$100 Genome
cheap genomes
cancer systems biology
+
=
simple blood tests for cancer
The End of
Mammograms
Colonoscopies
&
?
2017
human genomes
but still slow progress on
complex genetic diseases
first
1 million
and
is now
>
But only by reducing reports
from
200+
to
30+
microorganisms = factories
synthetic biology
industrial biology
industrial chemicals - food - agriculture textiles - biofuels - medical research
or
DNA = blueprints
new factories = exponential
& portable
sustainability
price & supply chain disruption
1.5 million
customers?
igital
D
iology
B
More Human Embryos Edited by CRIPSR
Zika
& gene drives
rapidly push
new DNA through
whole population
in the wild
CRISPR/Cas9
is a Swiss Army Knife for
Genes
and regulatory regions
Knock-out
Knock-in
Repair
Edit
cheap
highly targeted
improvable
they work,
everywhere
Human
Infertility
Prenatal Genetic Dx
Mitochondrial Therapy
Germ-Line Therapy
Enhancement
- Disease Risk
+ Intelligence
+ Longevity
NOW
NEXT
genetic
engineering
24 Aug 2017
Cellular Agriculture
Mark Post
Explosion of
consumer genomics
250+ companies
Ancestry
Athletic
Child talent
Matchmaking
Surreptitious
Non-legal paternity
Legal paternity
Nutrigenomics
Family
Carrier
Health testing
Microbiome
Pets
Food
desktop bioproduction lab
$1699
reprogram
microbes
Rise of the
Biotech
Garage
Inventor
bioprinter project
OpenPCR
$599 DNA Copy Machine
+
Cow-Free
Milk & Cheese
Boston
Paris
San Diego
Seattle
Oakland
Portland
Manchester UK
Biologigaragen
Biospace
Victoria, Canada
Copenhagen
Switzerland
Brooklyn
Sao Paolo
San Francisco
Shenzhen
Tokyo
Bio
Garage
Baltimore
Syn
Bio
Brasil
Launched at Singularity U 2014 Global Solutions Program
*
First clinical study, for gastric cancer, with Hospital Clínico Universidad Católica de Chile
microRNA diagnostics in low resource settings
Targeting emerging economies
Initial work completed at BioCurious in 5 weeks
Indie.bio, 479 Jessie Street, San Francisco, CA
sf.indiebio.co
Indie.bio, San Francisco
Counter Culture Labs, Oakland
Berkeley Biolabs, Berkeley
Janssen Labs + QB3, 953 & UCSF
Bay Area Biohackers
& Small Startup Labs
as New Models
Techshop
indie.bio
Hacker Dojo
Noisebridge
DARE2mansion
Hackteria
FabLab / HTGAA
Target CoLab
Janssen Labs
Silicon Valley
International
Corporate
National
Startup Chile
Hackerspaces
microRNA for diagnostics
EpiPen
Hack
$30 EpiPencil
Four Thieves Vinegar Collective
?
?
?
?
$1200 qPCR
Chai Biotech
Interpretation Websites
Promethease / SNPedia
Interpretome
LiveWello
Genetic Genie
23andMe
Ancestry.com
FamilyTreeDNA
Sources of DTC Genetic Data
buscando un bioinformático
coming
soon:
Fuel
?
Welcome to the
Consumer Genomics
Biohacking
Breakout Session
and/or
Raymond McCauley
Digital Biology:
@raymondmccauley
+1-650-776-4561
Life Is the New Black
Amniocentesis
Non-Invasive
Prenatal Testing
versus
simulated photo, courtesy Natera
World’s biggest database of DNA
40+ million people
China’s Ministry of Public Security
12.7 million offender profiles
migrant workers
college students in high theft areas
Xinjiang Uyghur Autonomous Region
passport applicants, since Sept 2016
source: Human Rights Watch
ConservationX Labs
DNA Barcode Scanner
Maastricht University, Technical University Eindhoven, Singularity University
Human Embryos Edited by CRIPSR - HIV immunity?
April 2016
in United States, previously in China
to correct heart disease (MYBPC3 cardiac myopathy)
Cellular Agriculture
positives
fewer environmental impacts
safer, purer product
more consistent supply
no harm to animals
real world examples
meat with healthier fats
milk without lactose
eggs without cholesterol
rhino horn with no extinction
negatives
the "ick" factor
adapted from New Harvest
* not necessarily genetic engineering
MSTN
LRP5
APP
CCR5
PCSK9
FUT2
SLC30A8
Lean muscles
Extra-strong bones
Alzheimer’s-resistant/immune
HIV-resistant/immune
Lower coronary risk
Stomach flu resistant
Type 2 Diabetes
Genes to Knock Out
adapted from George Church, private communication
Behavioral and Mental Traits
MAOA gene & aggression
last to implement
poorly understood
Therapeutics,
then
Enhancement
Gene Expression
"gene doping"
EPO, red blood cell production
Myostatin, muscle growth inhibition
VEGF, blood vessel production
IGF-1, targeted muscle mass increase
redneck
genetic
engineering
Expresión genética
"dopaje genético"
EPO, producción de hematíes
Miostatina, inhibición del crecimiento muscular
VEGF, producción de vasos sanguíneos
IGF-1, incremento de masa muscular orientada
Locus of Control:
Individuals, Parents, Doctors, Legislators
Widening the Economic Gap
Different Nations & Societies
= Diverse Approaches
Ethics, Laws and Policies
Overcoming
Fear of Other / Fear of Change / Every SciFi Movie Ever
Garage Labs
PCR Machine
Gel Electrophoresis
Fridge & Freezer
Water & Bleach

Biosafety Cabinet
Scale & pH Meter
Photospectrometer
basic equipment set
bicycles & woodworking optional
Laptop & Wifi
Biohazard Disposal
Centrifuge
Pipettors
Autoclave
Multimeter
3D Printer
getting fancy
Biohacking
Resources
for Kids
bit.ly/kidbiohack
Copyright 2017, Raymond McCauley. All Rights Reserved.

Build Our Biotech Future
What do you do
when you have access to potentially
the most dangerous technology
the human race has ever seen?
Put it in the hands
of 5 year olds
as quickly as you can
Alzheimer's
Autism
Cerebral Palsy
Huntington's
Parkinson's
Stroke
Traumatic Brain Injury
Alopecia
Baldness
Burn
Cosmetic
Incision Recovery
Wound Healing
Facelift
Skin Resurfacing
Macular Degeneration, Cataracts
Deafness
Breast Augmentation
Breast Reconstruction
Kidney Regeneration
Liver Regeneration
Pancreas Regeneration
Intestine Regeneration
Heart Attack Repair
Heart Valve Replacement
Heart Regeneration
Bladder Regeneration
Genital Replacement
Infertility
Arthritis
Joint Injury Repair
Cancer Innate Immunity
HIV Treatment
Lupus
Multiple Sclerosis
Copyright 2016, Raymond McCauley, All Rights Reserved
Adapted from Paul Knopfler, Stem Cells, An Insider's Guide
Back Pain
Spinal Cord Regeneration
Stem Cells = Reprogramming Medicine
A hackerspace for biotech

First biohacker lab in the world

Committed to making biotech
accessible, affordable, and open to everyone

Located in Sunnyvale, California

501c3 all-volunteer community lab, supported by monthly memberships and classes
most innovative
education company
in the world
Top
100
#4
Prof. Tulio de Oliveira,
and collaborators
Drive innovation in global health
Reverse the brain drain
Academic, govermental, and commercial
Work on HIV, TB, drug resistance

Platypus
Project
Applying exponential technology
to global grand challenges
Pharmacogenomics at scale
for health systems
Edtech for biology hacking
Raymond McCauley - Current Work
I0
Base
Copyright 2017, Raymond McCauley. All Rights Reserved.
Alltech
Beyond Meat
CellPod
Clara Foods
Hampton Creek
Impossible Foods
Modern Meadows
Nutrigene
Perfect Day/Muufri
Shojinmeat Project
Six Foods
Soylent
Initiatives
To
Watch
New Foods Sector
Microbiomes
& Metagenomics
Weight Loss Success Determined by
Two Gut Microbiota Species
uBiome
Farmville
Zynga
nutrigenomics
farm robotics
biomimicry
crop de-extinction
soil microbiomes
livestock genomics
water remediation
radical polyculture
bioculture
sensing (vision)
aquaculture
heterotrophic algae
bioenergy
data-intensive farming
pharming / manufacture
food security
genetic engineering
tissue engineering
animal-free protein
food tracking
supply chain automation
hyperspectral imaging
GMOs
digital labels
Digital
Agriculture
microirrigation
Ag biotech tracking map for World Bank, 2017
Copyright Raymond McCauley
exoproteins
cellular agriculture
environmental reclamation
*
*
*
*
*
Not
this kind of Digital Agriculture...
Advisor & Investor
Various Media Projects
programming bacteria
to monitor water quality
www.fredsense.com
portable, fast, easy, accurate biosensors
Calgary-based industrial biotech startup
"White Supremacists, You Won't Like Your Tests Results"
Digital Biology:
&
September 2017, Arne Astrup, et al, University of Copenhagen
@LIVCPH
for Innovation
and Accelerators
Aubrey
de Grey
Chief Science Officer
SENS Research Foundation
Longevity
People and Nations
Get Richer
Work Longer
More Education Time
Hyperexperience
Financial Behaviors Change
Underestimate Savings Need
Health Care Costs Increase
Active Retirements
Pensions Recalculated
Inheritance Decrease
the Longevity Dividend
+ 3.0 months / year
+ 2.5 months / year
Radical Biotechnology
& Fintech
Old Institutions Break
Insurance
Pensions
Retirement
Social Security
people aged 50+ equal
a global market nearly the size of China
Longevity Escape Velocity
current progress towards
}
demographics shift
Find me on
and

@LIVCPH
Raymond McCauley, @raymondmccauley
& New Food
Yuki
Hanyu,
Tokyo
DIY cultured meat
+ desktop myoformers
+ manga
working on
$499
and
$199
models

Investment Syndicate
Platypus
Project
Projects in non-traditional biotech
Educational tech for biology hacking
Raymond McCauley - Current Work
Advisor & Investor
Various Media Projects
&
CAR-T
Chimeric
Antigen
Receptor
T-Cell
Therapy
A type of adoptive cell transfer (ACT)
Collect patients’ own immune cells
Program disease recognition regions
Multiply outside body and reinsert
Kymriah
Kymriah (tisagenlecleucel) from Novartis
Targets CD19 protein, on cancerous B cells
First FDA approved CAR-T, 30 Aug 2017
Treats acute lymphoblastic leukemia (ALL)
first gene therapy in US
first FDA approved CAR-T
first personalized drug?
cons: $475K a dose, complicated process, cytokine storm
pros: "wonder drug" - about half in remission after 12 months
{
HOW TO PRONOUNCE
Kim

Kardashian
Ma
riah

Carey
+
Source: @abbynac
Yescarta
axicabtagene ciloleucel
large-B-cell lymphomas
approved 18 Oct 2017
Kymriah
tisagenlecleucel
acute lymphoblastic leukemia
approved 30 Aug 2017
JCAR017, PLAT-0x
axicabtagene
NHL, ALL
in trials
Amgen, Celegene, Bellicum Pharma, Cellectis,
Johnson & Johnson, Juno, Kite/Gilead, Novartis, Pfizer, Unum Therapeutics
AGTC, Audentes, Avalanche Biotech, Biomarin, Biogen Idec, Celladon, Dimension Thera, GSK, Noavartis, Shire, Spark Thera, uniQure, Voyager
Crispr Thera, Editas, Intellia, Sangamo,
More CAR-T
Gene Therapy
Gene Editing
What Happens Next in CAR-T
Selected Companies
Discount code:
BLOODMUSIC at checkout
"EZ Bake Oven for Genetic Engineering"
Then:
Chemistry Kit
Now:
Biology Kit
Cognitive
Genomics
+
Testing
then
Embryo Selection
then
Genetic Manipulation
Liquid Biposies
5.5M+?
Ancestry.com
, 2.5M+?
23andMe
USA FBI’s national DNA index
copyright 2017, Raymond McCauley. All Rights Reserved.
CRISPR Home Movie
Adapted from Nureki, et al "Real-space and real-time dynamics of CRISPR-Cas9 visualized by high-speed atomic force microscopy"
Nature Communications
Nov 2017, doi:10.1038/s41467-017-01466-8
First (official) gene-therapy in body
At UCSF Beniof, 44 year-old Brian Madeux
Hunter's Syndrome
(missing enzyme in carbohydrate metabolism)
Most die before teens
Replaces 2-3x weekly enzyme transfusions $100Ks/year
one delivery virus + one gene + 2 ZFPs
developed by
Sangamo Therapeutics
Adapted from "AP Exclusive: US scientists try 1st gene editing in the body",
AP News
, 15 Nov 2017
frequent colds and ear infections, distorted facial features, hearing loss, heart problems, breathing trouble, skin and eye problems, bone and joint flaws, bowel issues and brain and thinking problems.
Hunter Syndrome Symptoms
“I’ve been waiting for this my whole life, something that can potentially cure me.”
Three Things
image courtesy of
MIT Technology Review
image courtesy of Würzburg University, hudeceklab.org
www.bioclub.org
Tokyo Biohackerspaces

Pharmacogenomics
Traditional Treatment
Personalized Treatment
+
Adapted from Genesis Genome
pølse?
undskyld
Jane Doe
Female, 36, Non-smoker, BMI=19
Scenario 2: Deny Coverage
Chilling effect on life-saving genetic testing
Scenario 1: Ignore Genetic Tests
Alzheimers, Familial Cancer High Risk, ...
Personal Genetic Testing
Breaks Insurance
Patient's finding long-term care issues
5X more likely to buy long-term policy
- Dr. Green, Brigham and Women's Hospital, Personal Communication
Legal backlash
Oregon, Vermont - ban genetics + life ins California, Texas, New York, US - next?
25% of test refusers: fear
life insurance discrimination
But BRCA1-positive
~60% breast cancer risk
versus ~12% general risk
Scenario 3: Be the Solution
Genetic Test,
BUT
Hold Premiums Steady
Encourage clients to screen, take action
Preventive measures = Risk drops 87% to 5%
Genetic Testing
crushes
the Insurance Industry
"DNA methylation-based biomarkers, often referred to as '
epigenetic age
' or 'epigenetic clock', are robust estimators of chronological age of an individual..."
Life Epigenetics, Inc. & "DNA Age"
Bad News for Insurance
Regulation to restrict use of
genetic testing for inborn traits
to set premiums or deny coverage.
Good News for Insurance
genetic testing for acquired traits

Contact: Tom Nodine, tnodine@lifeegx.com
Implications for insurance and pension industries
GMOs

3.0
Genetically Modified Organisms
better yield
better nutrition
better digestion
drought tolerance
saline soil tolerance
fungus resistance
virus resisitance
Not conglomerate, but family orchard
Not implanted genes, but adjusted genes
Not hidden, but branded and labelled
Okanagan Specialty Fruits
Canadian company acquired by Intrexeon, Feb 2015, $41M
Simplot Innate Potato
Digital Agriculture
Genetically
Modified
Little
Mermaid
Bjørn Nørgaard's
Arctic Apples
"gene-silenced"
Cellular Agriculture
Mark Post
Maastricht University, Technical University Eindhoven, Singularity University
& New Food
EU's Horizon 2020
Q1 2018
Josiah
Zayner
Former NASA biologist
Self-experimenter
DIY GE kits at the-odin.com
Dangerous?
Reportedly, athletes are hacking genes
in
muscle groups, bloodstream, lung surface, and microbiome
, for
energy, endurance, metabolism, hormone increase, recovery, and cognition
.
Discount code:
BLOODMUSIC at checkout
"EZ Bake Oven for Genetic Engineering"
A hackerspace for biotech

First biohacker lab in the world

Committed to making biotech
accessible, affordable, and open to everyone

Located in Sunnyvale, California

501c3 all-volunteer community lab, supported by monthly memberships and classes
Brian Hanley, Butterfly Sciences;
GHRH for life extension, hyperimmunity, 2016
Elizabeth Parrish, BioViva;
telomerase & Alzheimer's treatments, 2015
Aaron Traywick & Tristan Roberts, Ascendance Biomedical; antibodies for HIV; herpes vaccine, fat/muscle control, 2016
Josiah Zayner, The Odin; GFP & myostatin, 2017
Examples of DIY Genetic Engineering
dangerously irresponsible? or pioneers?
biohacking
versus
body hacking
Pro/Am, DIY
& Biohacking
Pro/Am biotech company
Ascendance Biomedical
has gene hacking programs and trials to
reverse menopause, create a cocaine vaccine, cure genital herpes, change body odor, and resist Zika infection.
See Also:
Corbion, DSM, Novozymes, Danisco, DuPont Genencor, BASF, Advanced Enzymes, Enmex, Lonza Group, AB Enzymes, Chr. Hansen, Roche, ADM, Lesaffre Group, Adisseo France, Alltech
GMOs
versus
gene-edited
gene silenced
foods
&
also,
RNAi
= "natural bioprotection"?
"Cultured Foods"
Plant-based foods
versus
Pros
Cons
environmental impact
animal-cruelty free
regulation? labeling?
scale
Different nutrient profile
= Good or bad for you?
market perception
NEW HARVEST 2018
cellular agriculture & cell cultured products
MIT Media Lab
Cambridge, Massachusetts
July 20 & 21, 2018
new-harvest.org
Cellular Agriculture
Ask some
hard questions
Taste
Cooking and prep differences
{
Reprogramming Life
CRISPR
CAR-T
SCNT
programmable scissors for DNA
reprogramming immunity
reprogramming cells
Clustered Regularly Interspaced
Short Palindromic Repeats
Chimeric Antigen Receptor
T-Cell Therapy
Somatic Cell
Nuclear Transfer
RNAi
mute button for DNA
RNA
interference
life-changing
&
industry crushing
These acronyms are
information asymmetry
insurers
insured
life, health, pensions, fintech
Nov 2018
Cellular Agriculture
Shojinmeat Project
Yuki Hanyu
"We want to grow meat like we brew beer"
Performance
Cardiac output (ACE)
Energy output (ADRB3)
Muscle efficiency (BDKRB2)
Muscle function (ADRB2)
Oxygen capacity (ADRB1)
Training response (EDN1)
Toughness
Bone strength (SOST)
Joint strength/flex (COL5A1)
Muscle power (AGT)
Muscle force (ACTN3)
Muscle mass (VDR)
Strength building (MSTN)
Resilience
Cell repair (SOD2)
Cellular health (NFE2L2)
Inflammation (CRP)
Pain tolerance (GCH1)
Pain sensitivity (SCN9A)
Motivation/Spirit
Empathy (OXTR)
Happiness (FAAH)
Learning ability (Chromosome 6)
Memory (SNAP25)
Warrior or worrier (COMT)
John Lynch Gameplan
$79
"This 22-gene profile reveals whether your genes have the raw potential football legend John Lynch looks for in a player, from power and flexibility to resilience and spirit."
Science & Marketing
Advanced biotechnology company
using consumer genomics to better understand human disease and develop stem cell theraputics

Biobank of the Future?
&
Exponential Biosciences
Kopi Luwak
or
Civet Coffee
&
co-founders:
Abi Ramanan
Gustav Nipe
multispectral sensors
for food quality
and waste reduction
Solugen
Full transcript