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ramos Ernesto

on 20 January 2013

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Transcript of DNA

The Explorer, the Investigator and the Organizer The Chronicles of DNA Friedrich Miescher: The Explorer The Big Picture Experiment Conclusions He determined that nuclein was made up of hydrogen, oxygen, nitrogen and phosphorus and there was an unique ratio of phosphorus to nitrogen. He was able to isolate nuclein from other cells and later used salmon cells (as opposed to pus) as a source. Phoebus Levene: The Investigator Experiment Conclusions Tetranucleotide Erwin Chargaff: The Organizer Conclusions Chargaff's Rules Experiment 1871 1950 1844- 1895 1869-1940 1. the number of adenine (A) bases always equals the number of thymine (T) bases and the number of guanine (G) bases always equals the number of cytosine (C) bases
2. the composition of DNA, ATCG, varies from one species to another **we now know that A-C or T-G cannot form because a purine has to bond with a pyrimidine 1905
*** His model shows 3' to 5' phosphodiester linkages like the model made by Watson and Crick however he treated it as a separate molecule instead of one whole as well as the bases are outwards rather than in. 1859
1865 "... But as they did not seem to know much about anything, I was not unduly surprised ... I believe that the double-stranded model of DNA came about as a consequence of our conversation."

"technology of genetic engineering poses a greater threat to the world than the advent of nuclear technology." Bibliography
1. "Concept 15DNA and Proteins Are Key Molecules of the Cell Nucleus." Friedrich Miescher. N.p., n.d. Web. 15 Jan. 2013.
2. "DNA Structure: The Discovery of Nucleic Acid Structure." Bright Hub. N.p., n.d. Web. 15 Jan. 2013.
3."Tetranucleotide Hypothesis." Tetranucleotide Hypothesis. N.p., n.d. Web. 15 Jan. 2013.
4. "Concept 15DNA and Proteins Are Key Molecules of the Cell Nucleus." Phoebus Levene. N.p., n.d. Web. 15 Jan. 2013.
5."Erwin Chargaff." â Biography. N.p., n.d. Web. 15 Jan. 2013.
6."Chargaff's Ratios, 3D Animation with Narration :: DNA Learning Center." DNALC Blogs. N.p., n.d. Web. 15 Jan. 2013.
7.Gerards, Susanne, Keith Gibbons, Susan McCallum, Robert Noble, Jennifer Parrington, Clyde Ramlochan, and Sharon Ramlochan. "DNA Structure and Organization in the Cell." Biology 12. By Trent Carter-Edwards. Toronto: McGraw-Hill Ryerson, 2011. 208-09. Print.
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