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Asmah Yousef

on 7 December 2013

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Transcript of MERS-CoV

Middle East Respiratory Syndrom
Saudi Arabia
This new coronavirus is now known as Middle East respiratory syndrome coronavirus (MERS-CoV).
It started making people ill in the Middle East in 2012 and was first identified when a man in Saudi Arabia came down with "SARS-like" symptoms. He died in June 2012.
What's Coronavirus

The name "coronavirus" is derived from the Latin corona, meaning Crown. The virus has a crown-like projection on its surface, which is how it got its name. Corona viruses are a group of viruses that infect the respiratory tract of both humans and animals. Some corona viruses affect the digestive system.
The Middle East respiratory syndrome coronavirus is the most recent virus which was reported on 24th of September 2012 by an Egyptian virologist Dr. Ali Mohamed Zaki in Jeddah, Saudi Arabia. And this Virus is a Betacoronavirus, a novelcoronavirus, which is known as The Middle East respiratory syndrome coronavirus (MERS-CoV).
history of CoV
first CoV was discovered in 1965.
then the SARS outbreak in 2002 was believed to be caused by a new type of corona virus.
The novel coronavirus, first detected in April 2012, is a new virus that has not been seen in humans before. In most cases, it has caused severe disease. Death has occurred in about half of cases.
The name "coronavirus" is derived from the Latin corona, meaning crown.
This morphology is created by the viral spike (S) peplomers, which are proteins that populate the surface of the virus and determine host tropism.
The MERS-CoV has a strong tropism for nonciliated bronchial epithelial cells, and it has been shown to effectively evade innate immune responses and antagonize interferon (IFN) production in these cells. This tropism is unique in that most respiratory viruses target ciliated cells.
Mode of transmission
On 13 February 2013, WHO stated "
the risk of sustained person-to-person transmission appears to be very low.
" The cells MERS-CoV infects in the lungs only account for 20% of respiratory epithelial cells, so a large number of virions are likely needed to be inhaled to cause infection. Transmission has occurred in health-care facilities, including spread from
patients to health-care providers
Middle East respiratory syndrome coronavirus
A few months later, a man from Qatar became ill with similar symptoms after returning from a trip to Saudi Arabia. He was airlifted to the United Kingdom.
In UK further treatment, where laboratory tests confirmed he had been infected with MERS-CoV.
How widespread this virus may be is still unknown. but According to Margaret Chan, Director General of WHO,
"(MERS-CoV) is a threat to the entire world".
Because over
of people infected with MERS-CoV so far have died while SARS-CoV had a death rate of approximately
and the experts have noticed that MERS-CoV is more human-transmissible in

hospital settings
than originally thought. So far, Nine countries have now reported cases of human infection with MERS-CoV. Cases have been reported
in France, Germany, Italy Jordan, Qatar, Saudi Arabia, Tunisia, the United Arab Emirates, and the United Kingdom.
All cases have had some connection (whether direct or indirect) with the Middle East.

Sign and symptoms

₪ Coughing
₪ Mucous
₪ Shortness of breath
₪ Malaise - a general feeling of being unwell
₪ Chest pain
₪ Fever
₪ Diarrhea (in some cases)
₪ Renal (kidney) failure

Kidney failure
Death - over 60% of infected patients die

Can be identified by RT-PCR and also by taking some samples such as:
Bronchoalveolar lavage or sputum
also by using biologically safe immunofluorescence assays (IFA).

There are no specific treatments and No vaccine is currently available.
But SARS Virus Treatments Could Hold the Key for Treatment of MERS-CoV Outbreak.
IFN-B and Ribavirin combination do affect MERS-coV replication.
People Susceptible to MERS-CoV
Patients with chronic diseases, such as diabetes and heart conditions
Organ transplant recipients who are on immunosuppressive medications
Other patients whose immune systems are weak, such as cancer patients undergoing treatment

Avoid contact with people with symptoms of disease.

Maintain good hand hygiene.

Avoid unwashed vegetables and fruits.

Avoid uncooked or undercooked meats.

Make sure the water you drink is sterilized

Done by :- Asmah Al-Dobashi / 5387
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