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systemic lupus

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mehria gawhari

on 6 May 2015

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Transcript of systemic lupus

Chronic inflammatory multisystem autoimmune disease
Systemic

lupus

erythematosus

Created by: Mehria Gawhari
( 24 countries) 30-50 per 100,000 people.
Cutaneous lupus erythematosus
Discoid lupus erythematosus
Drug-induced lupus
Neonatal lupus
autoimmune
immunological tolerance
gentic
gender & hormone
age
ethnic
family history
envioronmental triggers
drug
What is SLE?
lupus=wolf, erythematosus=red
Epidemiology
Types
Etiology
&
Pathophysiology
20-100 different factors
HLA region on chromosome 6
environmental triggers
infection
UV rays
Risk factors
53 per 100,000 people
40 per 100,000 people
Viruses (Epstein-Barr virus )
Sunlight (UVB)
Smoking
Chemicals (Silicone)
contraceptives
More than 38 medications can cause this condition
the most common are:
procainamide
isoniazid
hydralazine
quinidine
phenytoin
Signs
and
Symptoms
Dermatological
Musculoskeletal
Hematological
Cardiac
Pulmonary
Renal
Gastrointestinal
CNS
Reproductive
Infections
joint pain
with remission
Less destructive
osteoarticular TB
pleuritis
pleural effusion
lupus pneumonitis
pulmonary hypertension
pulmonary emboli
pulmonary hemorrhage
nausea
weight loss
mild abdominal pain
diarrhea
heartburn
organs located in the GIS
lupus nephritis
edema
kidney failure

headaches
depression
seizures
cognitive dysfunction
mood disorder
cerebrovascular disease
polyneuropath
anxiety disorder
psychosis
spontaneous abortion
Neonatal lupus
worsen symptoms
Diagnosis
Anemia
Antiphospholipid Syndrome
Vasculitis
Thrombocytopenia
Leukopenia and Neutropenia
Blood Cancers
pericarditis
myocarditis
endocarditis
atherosclerosis
Anemia
Vasculitis
Thrombocytopenia
Leukopenia and Neutropenia
Blood Cancers
pleuritis
pleural effusion
lupus pneumonitis
pulmonary hypertension
pulmonary emboli
pulmonary hemorrhage
nausea
weight loss
mild abdominal pain
diarrhea
heartburn
disorders of organs located in the GIS
lupus nephritis
edema
kidney failure

headaches
depression
seizures
cognitive dysfunction
mood disorder
cerebrovascular disease
polyneuropath
anxiety disorder
psychosis
spontaneous abortion
Neonatal lupus
worsen symptoms
symptoms
medical history
physical exam
lab test
biopsy
MD BRAIN SOAP
B=blood cells, R=renal, Raynauds, A=ANA, I=immunologic (anti-Sm, anti-dsDNA), N=neuropsych
M(malar rash)
D(discoid rash)
S=serositis, O=oral ulcers, A=arthritis, P=photosensitivity
B=blood cells, R=renal, A=ANA, I=immunologic (anti-Sm, anti-dsDNA), N=neuropsych
lupus band
Treatment
No treatment cures systemic lupus erythematosus, but many therapies can suppress symptoms and relieve discomfort.
Treatment for Mild SLE
Creams
Sun Protection
Nonsteroidal Anti-inflammatory Drugs
Antimalarial Drugs (Hydroxychloroquine,chloroquine)

Treatment for Severe SLE
Corticosteroids (prednisone, methylprednisolone, dexamethasone)
Immunosuppressant Drugs (Cyclophosphamide, Mycophenolate, Cyclosporine)
Biologic Drugs (Belimumab )

life style changes
Staying Active
Preventing Infections
Avoiding SLE Triggers
Reducing Stress
Prognosis
chronic
relapsing
Symptom-free
complications and extensive
mild form

Facts
The primary cause of death in lupus patients is kidney disease.
It takes an average between 3 and 5 years from onset of symptoms to get a diagnosis of lupus.( mimic)
Lack of understanding and awareness is the hardest symptom to deal with.
20 years ago only 40% of patients were expected to live for 3 years after being diagnosed, but now 80-90% of patients can have a normal lifespan.
Patients can have blood donation.

Thank

you
!

joint pain
usually does not cause severe destruction of the joints
osteoarticular tuberculosis
ANA (anti-sm, anti-DNAds)
LE cells tests
blood tests
others
Full transcript