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Mitosis and Cancer project

Why mitosis can lead to cancer

Jack Daneil

on 13 November 2013

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Transcript of Mitosis and Cancer project

Mitosis and Cancer Project
Brain Cancer
Chemo side effects
With Chemotherapy killing unhealthy cancer cells, it can also damage healthy cells by stopping their mitosis. For example, disrupting the mitosis of root hair cells means that they can't divide hair cells, leading to hair loss, while damaging blood cells causes fatigue, anemia and can make you more susceptible to infections. Damage to mucous membrane cells can cause digestive problems like diarrhea, as well as mouth sores. [5]
Brain Cancer Chemotherapy

(Alkylating agents.)
Alkylating agents. These drugs alkylate the DNA, disrupting its replication and interfering with cell division. To alkylate means to put a methyl or other small alkyl group onto the DNA molecule. (Alkylates are like nitrogenous bases). Cytoxin, ifosfamide, and busulfan are alkylating agents. In general, these are fairly aggressive chemotherapy agent. In Brain Cancer chemotherapy can be more complicated because the brain is protected by a filter called the blood-brain barrier. One way to get the chemotherapy drugs in is by injecting the drug Methotrexate into the spinal cord, called Intrathecal Treatment, which lets the drug circulate throughout the brain, distributing it. [3] [6]
[1] Notes from science notebook
[2] http://nuclearchem.wikispaces.com/How+Radiation+Is+Used+In+Cancer+Treatments
[3] http://www.acco.org/information/drugsaction.aspx
[4] http://www.medicinenet.com/brain_cancer/page2.htm
[5] http://www.cancercare.org/publications/24-understanding_and_managing_chemotherapy_side_effects
Regular cells VS Brain cancer cells
By Team Awesome Guys
(Austins, Jared Greisz,
Jacob Schafte)

Period 3
Cancer is a term for diseases when abnormal cells divide and invade other tissue and organs. It is the second leading cause of death in the U.S., and more than 1.5 million Americans are diagnosed with some form of it every year. Brain cancer is a disease in the brain in which cancerous cells arise in brain tissue. Cancer cells grow to form a mass in the brain tissue, a tumor. This interferes with brain functions such as muscle control, memory, sensation and other regular body functions. 22000 people a year will be diagnosed and of that 13000 will die. [5]
Alkylates working on a cellular level
Other Forms of Curing Cancer
Surgery and radiation treatment are other ways to cure cancer although they will kill brain cells and can have deadly side affects to the brain. It is possible to completely remove the tumor with surgery but sometimes radiation is used to take care of what's left. [7]
Symptoms of Brain Cancer
There are many symptoms of brain cancer, some of theses symptoms include difficulty walking, seizures, headaches, nausea, vomiting, blurred vision, and change in alertness, speech or personality. Many of these symptoms have multiple possible causes, so if you have one or more of these symptoms it does not always mean you have cancer. [7]
Unregulated mitosis can lead to brain cancer and other cancers. Cells that would usually stop replicating or replicated at a normal speed start to replicate faster than normal due to a mutation where the Proto-oncogenes, which normally help cells divide, are stuck constantly dividing. The tumor Supressor genes have the task of stopping unhealthy cells from dividing. If they are also mutated, then this leads to a tumor, or mass of extra cells. The tumor is cancerous if these cells can get through boundries and to other areas of the body, infecting them. [1]
Unregulated mitosis
How chemotherapy works
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