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Genetic Contributions to Brain Structure
Transcript of Genetic Contributions to Brain Structure
Peter T. Fox
Jack W. Kent Jr.
Tom and J.-B. The Institute of Living 734 Covariates Visit our posters: WTh-PM Correlations Phenotypic Genetic & Environmental Methods:
486 subjects, pedigrees
Age 26-85, mean 48, sd 13
Variance components Cortical
Volume Surface-based Volume-based SOLAR Gyrification Index
Curvature Indices h = 0.56-0.92
Cognitive performance Head circumference
Harvard-Oxford Atlas Should we correct for
global measurements? Yes No Covariate is not correlated to the measurement under study.
Interested on both regional and global effects on the measurement. Covariate correlated to the measurement under study.
Interested on regional effects only, not global effects. Peper et al., 2007;
Glahn et al., 2007;
Schmitt et al., 2008;
Kaymaz & van Os, 2009. Winkler & Glahn, unpublished;
Kremen et al., 2010;
Goldman et al., 2008; VBM Bookstein, 2001;
Hayasaka et al., 2004;
Ashburner, 2009. Issues for
Imaging Genetics Ashburner, 2009. Folding Thickness Misclassification Misregistration both If in doubt, do Study the results. General Issues Voxel-Based Morphometry Product of area per thickness;
Variance across subjects is not only due to subject differences, but different influcences of thickness and area on volume between subjects and brain regions. Carson, 2006. Kremen et al., 2010. Lunde et al., 2007. Reviews Regional Volumes ENIGMA Consortium Highest: Postcentral 0.73; Cingulate, isthmus 0.72; Superior temporal 0.65; Superior frontal 0.63.
Lowest: Temporal pole 0.06; Orbitofrontal, lateral 0.10; Cingulate, rostral anterior 0.12. Heritability f0r
Cortical Thickness Winkler et al, 2010. Winkler et al, 2010. Heritability for Cortical Volume Goldman et al., 2009;
Rimol et al., 2009;
Lenroot et al., 2009;
Panizzon et al., 2009;
Winkler et al., 2010;
Brun, Joshi et al., 2010. Recent
Area Highest: Insula 0.76; Precuneus 0.69; Pericalcarine 0.68; Transverse temporal 0.67.
Lowest: Frontal pole 0.17; Fusiform 0.19; Cingulate, caudal anterior 0.23. Heritability for
Cortical Area Winkler et al, 2010. Kochunov et al., 2010. 718
WTh-PM Other traits Vertexwise
Voxelwise Unconstrained on space
Multiplicity of tests
Vertexwise area? Surface-based Volume-based bit.ly/hbm10 Baaré et al., 2001;
Thompson et al., 2001;
Hariri and Weinberger, 2003;
de Zubicaray et al., 2008. Further Reading: Meyer-Lindenberg et al., 2008. Thanks to: 739 WTh-AM 2 (in study) McKay et al., 2010. Brain Volume Indirect Measurements: