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Human In Vitro Fertilization

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Ferheen Abbasi

on 24 June 2015

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Transcript of Human In Vitro Fertilization

Human In Vitro Fertilization
Robert Edwards
Edwards was working on his PhD at University of Edinburgh in Scotland
Studied reproduction in mice
Conceived idea of fertilization outside of human body.
February 15, 1969 - First "test tube" fertilization

"Human oocytes have been matured and fertilized by spermatozoa in vitro."
July 25, 1978
Louise Brown was born
1986 - Large acceptance of IVF leading to 1,000 children born.
Nobel Prize in Physiology or Medicine
When a couple cannot conceive a child “naturally” - affects 10% of all couples.

Psychological: Disappointment, life-long trauma. Reduces quality of life. Increases risk of depression and social isolation

Medical = Poor sperm quality, lack of eggs, damage to fallopian tube, etc.
Bourn Hall Clinic
Further medical developments
Intra-cytoplasmic sperm injection
Vaginal ultrasound-guided oocyte recovery method
Fine needle used instead of laparoscopy
Oocytes/embryos can be frozen and saved.
20-30% of fertilized eggs develop into live-born children.
Higher frequency of multiple births
Preimplantation genetic diagnosis
Risks - Beckwith Wiedemann Syndrome and Angelman Syndrome
Pincus described experimental conditions that allowed mammalian oocytes to mature in vitro
Took eggs from a black rabbit fertilized in vitro by capacitated sperm from a black male and transferred to a white female resulted in the birth of a litter of black young.
Gregory Pincus - 1936
Min Chueh Chang - 1959
Yanagimachi & Chang - 1963
Fertilized hamster eggs in vitro without the use of in vivo activation of oocytes.

Sperm that were in female tract for longer period of time = higher rate of fertilization
July 12, 2008
Full transcript