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Glycolysis and Gluconeogenesis
Transcript of Glycolysis and Gluconeogenesis
Pay Off Phase (ATP produced)
Glucose+2ADP+2P+2NAD+ --> 2 pyruvate + 2 ATP +2 NADH +2H + 2H20 Lactic Acid Fermentation
Enters the citric acid cycle Arias C. et al. (2002) -Amyloid Neurotoxicity Is Exacerbated during Glycolysis Inhibition and Mitochondrial Impairment in the Rat Hippocampusin Vivo and in Isolated Nerve Terminals: Implications for Alzheimer's Disease. Experimental Neurology 176(1) 163-174http://dx.doi.org/10.1006/exnr.2002.7912
Bigl M. et al. (1999) Activities of key glycolytic enzymes in the brains of patients with Alzheimer's disease. Journal of Neural Transmission. 106: 499-511
Huang L. et al. (2004) Accumulation of high-molecular-weight amylose in Alzheimer's disease brains. Glycobiology. 14 (5): 409-416.doi: 10.1093/glycob/cwh042
McKee, T., & McKee, J. R. (2003). Biochemistry: The Molecular Basis of Life (3rd ed.). Boston: McGraw-Hill. Gluconeogenesis Investment Phase Glucose-->G-6-P [+18 KJ/mole]
ATP-->ADP + Pi [-32 KJ/mol]
Net delta G: -14 KJ/mol (-delta G) Coupled Reaction! Another coupled reaction!
Rate limiting step Fructose may enter here by phosphorylation. Pay Off Phase Oxidation-Reduction:
1. Glyeraldehyde-3-phosphate is oxidized to 1,3–bisphosphoglycerate.
2. NAD+ is reduced to NADH Coupled reaction, breakeven point What next? Regulation of Glycolysis Allosteric Regulation
Pyruvate Kinase Energetics of Glycolysis Reactions 1, 3, and 10
Reactions 2 and 4-9
Gluconeogenesis Questions? Fragen? Shitsumon? Jilmun? Domande? Ceisteanna? Pyetje? Galdera? Wen ti? Alzheimer's Disease Pentose Pathway: Oxidative Step Nonoxidative Pentose Pathway Products of Pentose Pathway 1. Ribose 5 Phosphate
2. Fructose 6 Phospate
3. Glyceraldehyde 3 Phosphate
3. NADPH Activities of key glycolytic enzymes in the brains of patients with Alzheimer's disease β-Amyloid Neurotoxicity Is Exacerbated during Glycolysis Inhibition and Mitochondrial Impairment in the Rat Hippocampus in Vivo and in Isolated Nerve Terminals: Implications for Alzheimer's Disease Accumulation of high-molecular-weight amylose in Alzheimer's disease brains