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CLIP: Longevity

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by

Raymond McCauley

on 31 July 2018

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Transcript of CLIP: Longevity

Squaring the
Survival Curve
Cell
Repair
Technologies
Accidental death
by 190
on average
Hans Rosling's
Gapminder
Beyond 120?
Death is not a Democrat
Alzheimer's
Autism
Cerebral Palsy
Huntington's
Parkinson's
Stroke
Traumatic Brain Injury
Alopecia
Baldness
Burn
Cosmetic
Incision Recovery
Wound Healing
Facelift
Skin Resurfacing
Macular Degeneration, Cataracts
Deafness
Breast Augmentation
Breast Reconstruction
Kidney Regeneration
Liver Regeneration
Pancreas Regeneration
Intestine Regeneration
Heart Attack Repair
Heart Valve Replacement
Heart Regeneration
Bladder Regeneration
Genital Replacement
Infertility
Arthritis
Joint Injury Repair
Cancer Innate Immunity
HIV Treatment
Lupus
Multiple Sclerosis
Copyright 2016, Raymond McCauley, All Rights Reserved
Adapted from Paul Knopfler, Stem Cells, An Insider's Guide
Back Pain
Spinal Cord Regeneration
Genetic engineering
Stem cell therapy
Melanoma repair
DNA cross-checking
DNA repair
DNA
Cryonic recovery
Cell reprogramming
Death Be Not Proud, Part 3
Cryonics for
Organ Replacement
Organ Preservation Alliance
DNA
Nanobots
Stem
Cell Tx
People and Nations
Get Richer
Work Longer
More Education Time
Hyperexperience
Financial Behavior Change
Underestimate Savings Need
Health Care Cost Increase
Active Retirements
Inheritance Decrease
Longevity Escape Velocity
+ 3.0 months / year
+ 2.5 months / year
http://rockhealth.com/tag/wearables/
"Cellular scissors chop up HIV virus"
Salk Institute
Nature Communications "Use of the CRISPR/​Cas9 system as an intracellular defense against HIV-1 infection in human cells", Liao et al
23andMe and Apple
enter drug research business
"crowd-sourced clinical trials"
Apple ResearchKit
- Asthma
- Parkinson's Disease
- Breast Cancer
- Diabetes
- Cardiovascular
Enrolled 7400+ people in 24 hours.
Previous largest study was 1700.
Life Expectancy +25

Deaths in ages 85-110
2000: ~50%
2030: ~10%
Death Be Not Proud, Part 2
Genome Project Dividend
Worldwide Infectious Disease
Extend Healthspan
cancer
cardiovascular disease
neurological conditions
Autoimmune, Affluence
Health Surveillance
Quantified Self
Biosensors
People who never got:
cancer
cardiovascular disease
neurological conditions
Q: Secret to live a long time?
A: Pick good parents!
Longevity
Limit at 120, for a while
Overpopulation? No
Proposal: Longevity Lab
Pensions & Advanced Health Accounts
It Varies, by Disease & Country
Longevity Lab
At 50
first colonoscopy,
then every 5-10 years
(more or earlier if higher risk)
Every Year
blood pressure (or more)
flu shot
mammogram (monthly self exam)
dermatology screening
eye exam (age 55+, every 2 years before)

Every 3 Years (at least)
cholesterol profile + fasting blood sugar test
pelvic exam / pap smear / HPV test (ages 30-65)
At 50
first prostate exam,
then every year
(earlier if higher risk)
THIS IS YOUR HOMEWORK - PUT IN ON YOUR CALENDAR
Schedule Health Maintenance
Might Not Hurt / As Needed
Vitamin Supplements
Weight Record - Daily or Weekly
Cholesterol Particle Size Test
VAP Test, VAP Diagnostics
Lipoprotein Particle Profile (LPP) Test, SpectraCell
NMR LipoProfile Test, LabCorp
Cardio IQ Report, Quest Diagnostics
Body Scan
Low-Dose Aspirin
Genetic Scans
Cholesterol Particle Size Tests
Pharmacogenomics
Nutrigenomics
Clinical Genomics (ACMG)
Stop Smoking
Lose Weight
Exercise Regularly
Internet-connected Scales
MD weight loss programs
FMD - fast mimicking diets
cognitive behavioral therapy (CBT)
personalized
evidence-based
gamified
QuitGenius
Nutrigenomics
(Prolon?)
counseling
+ drugs
+ measure/record
nutrients
carb & fat metabolism
food sensitivities
behaviors
3 Things
To Do Now

Microbiome Scan
$999 genome sequencing
+ interpretation
$199 BRCA testing
+ interpretation
+ counseling
+ updates
$29 superhero testing
+ scans variants for
strength
intelligence
speed
+ counseling
+ cape
for qualifying
individuals
veritasgenetics.com
getcolor.com
orig3n.com
genomics
& a Caveat
At 50
first colonoscopy,
then every 5-10 years
(more or earlier if higher risk)

Every Year
blood pressure (or more)
flu shot
mammogram (monthly self exam)
dermatology screening
eye exam (age 55+, every 2 years before)

Every 3 Years (at least)
cholesterol profile + fasting blood sugar test
pelvic exam / pap smear / HPV test (ages 30-65)

At 50
first prostate exam,
then every year
(earlier if higher risk)

THIS IS YOUR HOMEWORK - PUT IN ON YOUR CALENDAR
Schedule Health Maintenance
Common Drugs for Longevity
Longevity
rapamycin, metformin, beta blockers, statins, low dose aspirin
Full transcript