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Sickle Cell Anemia: Then and Now

Symptoms and treatment of Sickle Cell Anemia
by

Venecia Hillard

on 30 May 2011

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Transcript of Sickle Cell Anemia: Then and Now

Sickle Cell Anemia: Then and Now ahututuo
chwecheechwe nuidudui
nwiiwii ogbanjes Some african tribes had
as many as 40% of it's
memembers as sickle cell carriers "Case of the Absence of the Spleen" 1846 Body of a runaway slave autopsied The physician that performed the autopsy had no way of knowing the disease had not been "discoverd" yet In 1922 three more cases
were reported and the disease was
named Sickle Cell Anemia 1904 Dr. James Herrick reported
"peculiar elongated & sickle shaped
RBC's " in an intelligent negro of 20. Walter Clement Noel 1st sickle cell
pt.He came to Chicago to study Dentistry Walter came to the US to study
dentistry at one of the best schools
where he was one of the only black students.He died from pneumonia 3 yrs after completing his studies. Sickle Cell Anemia Sickle Cell anemia does single
out those from tropical and subtropical
climates of the Old World. Malaria One long-held theory as to why it is so common in the tropics is it's association with Malaria. E.A. Bect A British medical officer found that malaria pt's that had sickle cell trait had fewer malarial parasites in the blood Anthony Allison In 1954, continued to build
on these observations and hypothesized that sickle cell trait offered protection against malaria In areas repeatedly devastated by malaria, people who carry the sickle cell trait have a greater chance for survival. Sickle Cell Anemia is an inherited blood disorder characterized by chronic anemia, painful events, and various complications due to associated tissue and organ damage Cause Caused by a genetic change in the hemoglobin,the oxygen carring protein inside RBC's.The cells take on a sickled shape. Sickled cells have a life span of 10-12
days,whereas normal RBC's have a life span of 120 days. sickled cells are less flexible and stickier
than normal RBC's,this causes them to become trapped in small vessels, preventing blood flow and compromising the delivery of oxygen 250, 000: 1 wORLD wIDE African Americans
400: 1 Signs and Symptoms chronic anemia
infections and spleen damage
sickle cell crisis
delayed growth
stroke
acute chest syndrome
priapism(painful erection of the penis)
kidney disease
jaundice and gallstones
retinopathy
joint problems Diagnosis Hemoglobin electophoresis
Isoelectic focusing
High-performance liquid chromatography Modalities Penicillin
Pain Management
Blood transfusions
Hydoxyurea
Bone marrow transplantation
Surgery Psychosocial support Prognosis d ue to modern medicine and technology, most sickle cell patients live well into adult hood THe END
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