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Transcript of Internet addiction?
Internet Addiction (IA)
The term was first introduced in 1996 by Kimberly Young
Is IA a real addiction like substance addiction?
Pathological gambling in DSM-5
A Real Addiction?
People who support this idea:
The behavioral manifestations of IA are akin to substance addiction: excessive use, withdrawal, tolerance and negative repercussions (Block, 2008; Morahan-Martin, 2005).
The similarities also exist in natural history, phenomenology, and neurobiological mechanisms (Grant et al., 2010)
A Real Addiction?
People who oppose this idea:
IA should be classified as an impulse-control disorder (Treuder et al., 2001; Shapira et al., 2003).
IA may be no more than a symptom of other existing disorders such as depression (Young and Rodgers, 1998), suicide ideation (Kim et al., 2006) bipolar disorder (Shapira et al., 2000), and loneliness (Whang et al., 2003).
Previous studies on IA
Between 1996 and 2006, more than 120 peer-reviewed articles were published on Internet addiction.
Three studies introduced molecular genetics to the field of Internet addiction:
DRD2 gene Taq1A locus and COMT gene, Han et al., 2007
CHRNA4 gene, Montag et al., 2012
5-HTTLPR gene, Lee et al., 2008
These polymorphisms have been previously shown to associate with addictive disorders such as smoking, opium abuse and pathological gambling
Dopamine Receptor D4 (DRD4)
DRD4 gene encodes a transmembrane G-protein coupled receptor that responds to endogenous dopamine (McGeary, 2009).
The receptor mediates some of inhibitory impacts on neuronal firing in dopaminergic pathway (Rubinstein et al., 2001; Wang et al., 2004).
High level of expression of this DRD4 is found in prefrontal cortex, a region involved in cognition, attention and other brain functions (Oak et al., 2000).
DRD4 VNTR Polymorphism
- DRD4 gene contains a variable number of tandem repeats (VNTR) polymorphism in exon III that consists of a 48-bp repeat unit.
- This unit is repeated between 2 and 11 times with the most common versions being 2, 4 and 7 repeats (Van et al., 1992; McGeary, 2009).
Ding et al., 2002
Compared to the 4 repeat (4R) variant, 2 repeat (2R) and 7 repeat (7R) variants mediate a blunted intracellular response to dopamine (Asghari et al., 1995; Wang et al., 2004).
DRD4 and Substance Addictions
- People with the 7R variant have been found to demonstrate significantly higher craving for alcohol (Hutchison et al., 2002a), smoking (Hutchison et al., 2002b) and heroin cues (Shao et al., 2006). 7R variant was also found to be associated with pathological gambling (Castro et al., 1997).
- These associations could be due to the role of the mesolimbic dopamine system in the rewarding effects in substance addiction cases (Berridge, 2007).
- Drugs that activate dopamine neurotransmission short circuit and sensitize ordinary mesolimbic mechanisms that evolved to react appropriately to hedonic stimuli (Berridge, 2007).
DRD4 and ADHD
- ADHD is a condition with inattentiveness, over-activity, impulsivity, or a combination (Whalen and Henker, 1998; Schweitzer et al., 2001).
- Studies show 7R presents a higher risk of ADHD (Gornick et al., 2007; El-Faddagh et al., 2004; Li et al., 2006).
It worth noting that 2R variant, the shorter version of this polymorphism, manifests a similar phenotypic effect as 7R variant in both addiction and ADHD cases (Comings et al., 1999)
4R vs. 2R and 7R
DRD4 and Personality Traits
- DRD4 7R is associated with personality trait of novelty seeking (Becker et al., 2005)
- DRD4 7R is associated with higher instance of sexual infidelity and greater rate of sexual promiscuity (Garcia et al., 2010)
Subjects were recruited through a project called AFK (away-from keyboard) Weekend event at Binghamton University in April 2011.
Every participant had a chance to win one of four gift cards in a lottery.
Saturday: Stay away from the Internet.
Sunday: Allow to resume normal Internet use.
AFK Weekend Project
Primary Survey Outcomes
- DRD4 (4R group vs. 2R/7R group), DRD2, 5httlpr...
Internet usage pattern
- Frequency and duration of Internet use
- Online activity
Internet Addiction Test
- It consists of 20 questions, with each response measured on a six-point Likert scale
- The higher total score, the greater severity of addiction and more problems caused by Internet use.
- Seventy-three participants （age: 21.7, SD=4.1） came to donated their DNA samples and finished the pre-weekend survey.
- Fifty-seven participants came back and finished the post-weekend survey.
Statistic analysis show:
- 4R group and 2R/7R group had the same possibility not finishing the project.
- male and female had the same possibility not finishing the project.
- 98.6% participants use the Internet several times a day.
- An average time of 3.8 hrs (SD=2.0) is spent on the Internet every day.
- 70% spent more than one hour on the Internet in a single session
Gender difference in online activities
More males than females:
- searched and bought songs or music online
- downloaded TV shows
- movies and played online multiplayer video games
but not in "play social network games"
Fifty-six participants completed the IAT with an average score of 31.5 (SD=9.3)
Userｓ with significant problems （ＩＡＴ≥70）： ０
Ｕｓｅｒｓ ｗｉｔｈ ｆｒｅｑｕｅｎｔ ｐｒｏｂｌｅｍｓ （40≤IAT<70）： ８ （１４％）
Ｓｏ ｗｈａｔ ｗｅ ｃａｎ ｃｏｎｃｌｕｄｅ ｓｏ ｆａｒ？
Ｔｈｅ ｕｓｅ ｏｆ ｔｈｅ Ｉｎｔｅｒｎｅｔ ｈａｓ ｂｅｃｏｍｅ ａ ｃｏｍｍｏｎ ｐａｒｔ ｏｆ ｅｖｅｒｙｄａｙ ｌｉｆｅ ａｍｏｎｇ ｃｏｌｌｅｇｅ ｓｔｕｄｅｎｔｓ．
－ Popularity of social network sites: a useful tool to maintain relations with the missing offline community
- Use of online courseware systems
If the optimal amount of sleep for an adult is 8 hours a day, participants in our study spent an average of more than 20% (3.8 hr/16 hr) of their awake hours on the Internet.
DRD4 Polymorphism and Internet Addiction
Our results confirm the role of dopamine system in Internet addiction.
DRD4 7R is associated with higher Internet addiction score in female.
7R expresses a protective effect over Internet addiction?
Maybe the ADHD model can offer an explanation:
The inattentiveness and distractedness associated with DRD4 7R can actually protect their bearers from Internet overuse.
Compared to people in 4R group, people with 7R allele are less likely to stay focused in front of a computer or more easily distracted by other things, which leads to reduced time spent on the Internet and less likelihood to become excessive Internet users.
Spent more than 3 hours on Internet a day?
4R group: 36.3%
2R/7R group: 53.3%
4R group: 66.7%
2R/7R group: 31.3%
Protective effect of 7R allele
More male participants than females play online video games and watch downloaded TV shows and movies.
Both categories are quite time consuming and attention requiring.
Time spent on the Internet by male participants was more easily reduced by the presence of 7R
Another possible explanation:
- Maybe people with 7R are spending more of their spare time seeking and maintaining romantic relationships rather than using the Internet
Asghari, V, S Sanyal, S Buchwaldt, A Paterson, V Jovanovic, and H H Van Tol. 1995. “Modulation of Intracellular Cyclic AMP Levels by Different Human Dopamine D4 Receptor Variants.” Journal of Neurochemistry 65 (3) (September): 1157–65. http://www.ncbi.nlm.nih.gov/pubmed/7643093.
Berridge, Kent C. 2007. “The Debate over Dopamine’s Role in Reward: The Case for Incentive Salience.” Psychopharmacology 191 (3) (April): 391–431. doi:10.1007/s00213-006-0578-x. http://www.ncbi.nlm.nih.gov/pubmed/17072591.
Block, Jerald J. 2008. “Issues for DSM-V: Internet Addiction.” The American Journal of Psychiatry 165 (3) (March): 306–7. doi:10.1176/appi.ajp.2007.07101556. http://www.ncbi.nlm.nih.gov/pubmed/18316427.
Comings, D E, N Gonzalez, S Wu, R Gade, D Muhleman, G Saucier, P Johnson, et al. 1999. “Studies of the 48 Bp Repeat Polymorphism of the DRD4 Gene in Impulsive, Compulsive, Addictive Behaviors: Tourette Syndrome, ADHD, Pathological Gambling, and Substance Abuse.” American Journal of Medical Genetics 88 (4) (August 20): 358–68. http://www.ncbi.nlm.nih.gov/pubmed/10402503.
El-Faddagh, M, M Laucht, a Maras, L Vöhringer, and M H Schmidt. 2004. “Association of Dopamine D4 Receptor (DRD4) Gene with Attention-deficit/hyperactivity Disorder (ADHD) in a High-risk Community Sample: a Longitudinal Study from Birth to 11 Years of Age.” Journal of Neural Transmission (Vienna, Austria : 1996) 111 (7) (July): 883–9. doi:10.1007/s00702-003-0054-2. http://www.ncbi.nlm.nih.gov/pubmed/15206004.
Garcia, Justin R, James MacKillop, Edward L Aller, Ann M Merriwether, David Sloan Wilson, and J Koji Lum. 2010. “Associations Between Dopamine D4 Receptor Gene Variation with Both Infidelity and Sexual Promiscuity.” PloS One 5 (11) (January): e14162. doi:10.1371/journal.pone.0014162. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2994774&tool=pmcentrez&rendertype=abstract.
Gornick, M C, Anjene Addington, P Shaw, A J Bobb, W Sharp, D Greenstein, S Arepalli, F X Castellanos, and J L Rapoport. 2007. “Association of the Dopamine Receptor D4 (DRD4) Gene 7-repeat Allele with Children with Attention-deficit/hyperactivity Disorder (ADHD): An Update.” American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics 144B (3) (April 5): 379–82. doi:10.1002/ajmg.b.30460. http://www.ncbi.nlm.nih.gov/pubmed/17171657.
Grant, Jon E, Marc N Potenza, Aviv Weinstein, and David A Gorelick. 2010. “Introduction to Behavioral Addictions.” The American Journal of Drug and Alcohol Abuse 36 (5) (September 1): 233–41. doi:10.3109/00952990.2010.491884. http://informahealthcare.com/doi/abs/10.3109/00952990.2010.491884.
Han, Doug Hyun, Young Sik Lee, Kevin C Yang, Eun Young Kim, In Kyoon Lyoo, and Perry F Renshaw. 2007. “Dopamine Genes and Reward Dependence in Adolescents with Excessive Internet Video Game Play.” Journal of Addiction Medicine 1 (3) (September): 133–8. doi:10.1097/ADM.0b013e31811f465f. http://www.ncbi.nlm.nih.gov/pubmed/21768948.
Hutchinson, Kent E., John McGeary, Andrew Smolen, Angela Bryan, and Robert M. Swift. 2002. “The DRD4 VNTR Polymorphism Moderates Craving after Alcohol Consumption.” Health Psychology 21 (2): 139–146. doi:10.1037//0278-6126.96.36.199. http://doi.apa.org/getdoi.cfm?doi=10.1037/0278-6188.8.131.52.
Hutchison, Kent E., Heather LaChance, Raymond Niaura, Angela Bryan, and Andrew Smolen. 2002. “The DRD4 VNTR Polymorphism Influences Reactivity to Smoking Cues.” Journal of Abnormal Psychology 111 (1): 134–143. doi:10.1037//0021-843X.111.1.134. http://doi.apa.org/getdoi.cfm?doi=10.1037/0021-843X.111.1.134.
Kim, Kyunghee, Eunjung Ryu, Mi-Young Chon, Eun-Ja Yeun, So-Young Choi, Jeong-Seok Seo, and Bum-Woo Nam. 2006. “Internet Addiction in Korean Adolescents and Its Relation to Depression and Suicidal Ideation: a Questionnaire Survey.” International Journal of Nursing Studies 43 (2) (February): 185–92. doi:10.1016/j.ijnurstu.2005.02.005. http://dx.doi.org/10.1016/j.ijnurstu.2005.02.005.
Li, Dawei, Pak C Sham, Michael J Owen, and Lin He. 2006. “Meta-analysis Shows Significant Association Between Dopamine System Genes and Attention Deficit Hyperactivity Disorder (ADHD).” Human Molecular Genetics 15 (14) (July 15): 2276–84. doi:10.1093/hmg/ddl152. http://www.ncbi.nlm.nih.gov/pubmed/16774975.
McGeary, John. 2009. “The DRD4 Exon 3 VNTR Polymorphism and Addiction-related Phenotypes: a Review.” Pharmacology, Biochemistry, and Behavior 93 (3) (September): 222–9. doi:10.1016/j.pbb.2009.03.010. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2706302&tool=pmcentrez&rendertype=abstract.
Montag, Christian, Peter Kirsch, Carina Sauer, Dipl Psych, Sebastian Markett, and Martin Reuter. 2012. “The Role of the CHRNA4 Gene in Internet Addiction.” World Wide Web Internet And Web Information Systems 00 (00): 1–5. doi:10.1097/ADM.0b013e31825ba7e7.
Morahan-Martin, J. 2005. “Internet Abuse: Addiction? Disorder? Symptom? Alternative Explanations?” Social Science Computer Review 23 (1) (February 1): 39–48. doi:10.1177/0894439304271533. http://ssc.sagepub.com/cgi/doi/10.1177/0894439304271533.
Oak, James N, John Oldenhof, and Hubert H.M Van Tol. 2000. “The Dopamine D4 Receptor: One Decade of Research.” European Journal of Pharmacology 405 (1-3) (September): 303–327. doi:10.1016/S0014-2999(00)00562-8. http://dx.doi.org/10.1016/S0014-2999(00)00562-8.
Rubinstein, M, C Cepeda, R S Hurst, J Flores-Hernandez, M A Ariano, T L Falzone, L B Kozell, et al. 2001. “Dopamine D4 Receptor-deficient Mice Display Cortical Hyperexcitability.” The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 21 (11) (June 1): 3756–63. http://www.ncbi.nlm.nih.gov/pubmed/11356863.
Schweitzer, Julie B., Thomas K. Cummins, and Carole A. Kant. 2001. “ATTENTION-DEFICIT/HYPERACTIVITY DISORDER.” Medical Clinics of North America 85 (3) (May): 757–777. doi:10.1016/S0025-7125(05)70339-4. http://dx.doi.org/10.1016/S0025-7125(05)70339-4.
Shao, Chunhong, Yifeng Li, Kaida Jiang, Dandan Zhang, Yifeng Xu, Ling Lin, Qiuying Wang, Min Zhao, and Li Jin. 2006. “Dopamine D4 Receptor Polymorphism Modulates Cue-elicited Heroin Craving in Chinese.” Psychopharmacology 186 (2) (June): 185–90. doi:10.1007/s00213-006-0375-6. http://www.ncbi.nlm.nih.gov/pubmed/16703401.
Shapira, Nathan A, Mary C Lessig, Toby D Goldsmith, Steven T Szabo, Martin Lazoritz, Mark S Gold, and Dan J Stein. 2003. “Problematic Internet Use: Proposed Classification and Diagnostic Criteria.” Depression and Anxiety 17 (4) (January): 207–16. doi:10.1002/da.10094. http://www.ncbi.nlm.nih.gov/pubmed/12820176.
Shapira, Nathan A., Toby D. Goldsmith, Paul E. Keck, Uday M. Khosla, and Susan L. McElroy. 2000. “Psychiatric Features of Individuals with Problematic Internet Use.” Journal of Affective Disorders 57 (1-3) (January): 267–272. doi:10.1016/S0165-0327(99)00107-X. http://dx.doi.org/10.1016/S0165-0327(99)00107-X.
Treuer, Tamas, Zsolt Fábián, and János Füredi. 2001. “Internet Addiction Associated with Features of Impulse Control Disorder: Is It a Real Psychiatric Disorder?” Journal of Affective Disorders 66 (2-3) (October): 283. doi:10.1016/S0165-0327(00)00261-5. http://dx.doi.org/10.1016/S0165-0327(00)00261-5.
Van Tol, H H, C M Wu, H C Guan, K Ohara, J R Bunzow, O Civelli, J Kennedy, P Seeman, H B Niznik, and V Jovanovic. 1992. “Multiple Dopamine D4 Receptor Variants in the Human Population.” Nature 358 (6382) (July 9): 149–52. doi:10.1038/358149a0. http://www.ncbi.nlm.nih.gov/pubmed/1319557.
Wang, E, Y-C Ding, P Flodman, J R Kidd, K K Kidd, D L Grady, O A Ryder, M A Spence, J M Swanson, and R K Moyzis. 2004. “The Genetic Architecture of Selection at the Human Dopamine Receptor D4 (DRD4) Gene Locus.” American Journal of Human Genetics 74 (5) (May): 931–44. doi:10.1086/420854. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1181986&tool=pmcentrez&rendertype=abstract.
Whalen, Carol K., and Barbara Henker. “Attention-deficit/hyperactivity Disorders.” In .
Whang, Leo Sang-Min, Sujin Lee, and Geunyoung Chang. 2003. “Internet Over-users’ Psychological Profiles: a Behavior Sampling Analysis on Internet Addiction.” Cyberpsychology & Behavior : the Impact of the Internet, Multimedia and Virtual Reality on Behavior and Society 6 (2) (April 5): 143–50. doi:10.1089/109493103321640338. http://online.liebertpub.com/doi/abs/10.1089/109493103321640338.
Young, KIMBERLY S. 1998. “Internet Addiction: The Emergence of a New Clinical Disorder.” CyberPsychology & Behavior 1 (3) (January 29): 237–244. doi:10.1089/cpb.1998.1.237. http://online.liebertpub.com/doi/abs/10.1089/cpb.1998.1.237.
Cheng Sun 9/12/2013