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The ointment

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한방 약리학

on 1 June 2015

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Transcript of The ointment

The ointment
for the treatment
of atopic dermatitis

How to treat?
Concerntration of Vit.D in the body
Vitamin D functions
The creation of keratin membrane
Promotes the formation of the permeable barrier of lipid
Stimulates the synthesis of cathclicidin
which belongs to antibacterial peptides
Skin hot flashes
Dry skin
possibility of the secondary infection

Th1/Th2 Intercellular imbalance
Langerhans cell stimulation increased
The abnormality of cytokine : IL-4,IL-5,IL-10,IL-13 etc
The abnormality of prostaglandin
Abnormally increasing IgE in peripheral
Macrophage activation
Increase in eosinophils and ECP
Abnormality of immune system
of atopy
the etiology of atopy
Abnormality of immune system
can damage to the skin barrier.
Concerntration of Vit.D in the body
Lipid peroxidation
= Reactive oxygen species:ROS + Unsaturated fatty acids
Lipid peroxidation attached to the stratum corneum of the skin
makes skin dry
damages to normal tissue
easy to be infected
Lipid peroxidation
Macrolide compound
cyclosporin, tacrolimus, pimecrolimus
T cell에 작용해 세포 내 단백질, cyclophilin과 결합해 calcineurin 억제함
→ cytokine 유전자 전사 방해
표피지질의 불균형이 건조피부를 유발하고 피부장벽의 손상을 가져옴
이는 항원과 랑게르한스세포를 결합시켜 cytokine 이상을 가져오거나
감염으로 인해 결과적으로 염증과 표피의 과증식을 일으킴

감소한 세라마이드를 보충해 피부건조증을 치료하기위해 유사 합성 세라마이드를 사용할
수 있음

Kochia Scoparia
Dictamni Radicis Cortex
Silicon water
규소(Si)는 원래 인체 중 혈액, 뼈, 모발, 손, 발톱 등에 많이 포함되어 있는 생명 유지에 필수 불가결한 미량 미네랄로 이것이 인체에 윤활유 역할을 하고 있습니다. 피부가 윤택함을 유지하기 위해서 중요한 요소입니다. 하루의 규소(Si) 소비량은 일반 성인으로 10mg~40mg 정도이며, 섭취 방법은 주로 채소류로부터 입니다. 그러나 최근 농약을 사용한 야채로부터 규소(Si) 흡수량은 적어서 미량 원소의 미네랄 부족 현상이 일어나고 있습니다. 규소 부족으로부터 노화가 조기에 시작되고 또한 여러 가지 질환의 주된 원인이라는 것이 임상 연구로 밝혀지고 있습니다.
아토피환자는 대부분 피부열감과 상열감을 많이 느끼는데, 이는 과도하게 생성된 체열이 발산되기 위해 인체의 상부(호흡기)와 피부로 쏠리기 때문입니다. 피부열은 심한 가려움과 화끈거림을 일으키며 피부를 사막화시켜 보습, 방벽기능을 저하시켜 쉽게 피부염을 일으키게 됩니다. 또한 상열현상은 호흡질환을 불러와 비염, 천식, 폐렴, 기관지염 등이 생길 수 있습니다. 그러나, 상대적으로 인체의 중심부에는 혈액이 부족하여 냉한 현상이 생기는데, 이로 인해 소화기능이 떨어져 급체, 소화불량, 속쓰림, 과민성 대장질환, 구취, 심한 배변냄새 등이 생기기 쉽습니다.
From the oriental pharmaceutical point of view
Herbs that having pharmacological activities
*Atopy is caused by damp and heat
*Ponciri Fructus Immaturus
mechanism : inhibitory of IgE, IL-4 migration inhibitory of mast cells
*Lithospermi Radix
From the oriental pharmaceutical point of view
< Herbs that take damp and heat away >
Herbs that having pharmacological activities
@ mechanism of endogenous atopic dermatitis
Choi yo na
Kim jae eun
Kim jae eun
Choi yo na
Kim min choel
Yeo hye in
Baek un gi
Seo byeong ho
- Effect of Lithospermi Radix on Contact Dermatitis Induced by initrofluorobenzene in Mice -
<Journal of Pharmacopuncture 2012;15(2):007~010>
1. Effects of LR on skin
lesions in CD mice
Baek un gi
Requirements of the ointment
Relieve itching


Antibiotics for preventing secondary infection

Regeneration of cell

Preventing dry skin or moisturizing
2. Effects of LR on
hanges of tissues in CD mice
*Lithospermi Radix
3. Effects of LR on
production levels of
immunoglobulin in CD mice

Dioscorea japonica * - allantoin can hydrate corneous tissue
Choi yo na
Ceramide: Acanthopanax senticosus *chia seed oil *almond oil
Choi yo na
anti-inflammatory activity : lipopolysaccharide (LPS)-stimulated RAW264.7 murine macrophages

reduce prostaglandin E2 (PGE2) : production by inhibiting cyclooxygenase-2 (COX-2) expression proven on both mRNA as well as on protein levels

inhibit mRNA expressions of major pro-inflammatory cytokines
including TNF-α, IL-1β and IL-6
Kim jae eun
promoting the prevention of the virus and help prevent
infection of Chronic
to exercise their skin keratin layer to help
How can vitamin D helps atopic dermatitis?
*Ulmus davidiana var
Kim jae eun
Degranulation inhibited to the level of about who I won't be exposed to allergen an obstruction to the identified.

Seo byeong ho
It prevent tumor and activate skin cell organization. Also it treat many kind of inflammation and sterilize.

*Ponciri Fructus Immaturus
Yeo hye in
<European Journal of Pharmacology Volume 627, Issues 1–3, 10 February 2010, Pages 318–324>
- hispidol A 25-Me ether:
Kim min cheol
LR: Lithospermi Radix
CD: Contact Dermatitis
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