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OCW LU1 MDP10208 Pharmacology: Neurotransmitter
Transcript of OCW LU1 MDP10208 Pharmacology: Neurotransmitter
Tyrosine L-dopa Dopamine Noradrenaline Adrenaline
Release: exocytosis of neurotransmitter into synaptic cleft
need for calcium release
Summarizing the seven processes, we have:
Release/breakdown/exocytosis (of any neurotransmitter leaking from the vesicles)
Seven Processes in Neurotransmitter Action
Transport/Storage (in vesicles, docked at presynaptic membrane)
Role of monoamine transporter proteins - pump neurotransmitters into vesicles
Vesicles are targeted to dock at presynaptic membrane
At the end of the teaching session, you should be able to:
explain the seven processes involved in neurotransmitter action: systhesis, storage, release, receptor binding, reuptake, diffusion and inactivation.
explain (for each of the seven processes) the possible physiological effects after administration of a chemical that can disrupt that process.
Examples of neurotransmitters are
Amino acids e.g. glutamate,
Biogenic amines e.g. noradrenaline, acetylcholine,
Neuropeptides e.g. Substance P,
Gases e.g. nitric oxide
Naming of receptor and nerve: both follows name of neurotransmitter
e.g. Neurotransmitter: acetylcholine.
Binding of neurotransmitter to postsynaptic (or presynaptic) receptors
Reuptake of neurotransmitters into presynaptic neuron through transporters at plasma membrane
Neurotransmitters diffuse away from the synapse
Neurotransmitters inactivated by enzymes
Drugs Interfere with Neurotransmission
Drugs can affect synapses at a variety of sites and in a variety of ways, including:
1. Increasing number of impulses
2. Release NT from vesicles with or without impulses
3. Block reuptake or block receptors
4. Produce more or less NT
5. Prevent vesicles from releasing NT
e.g acetylcholine acetate + choline
What is a synapse?
There are dozens of different neurotransmitters
(NT) in the neurons of the body.
NTs can be either excitatory or inhibitory
Each neuron generally synthesizes and releases a
single type of neurotransmitter
old drugs like metyrosine, reserpine
botox (botulinium toxin)
neostigmine for treatment of myasthenia gravis
A synapse is the “gap” between the axon of
one nerve and the dendrite of the next one.
The average neuron has 1,000 synapses
with other neurons.
Image online, courtesy Weber State University. PD
Take a look at this video
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