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Optimising the clinical use of tomotherapy

Dissertation presentation
by

Kristoffer Petersson

on 12 February 2014

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Transcript of Optimising the clinical use of tomotherapy

2011
2012
2014
2010
2013
Master of Science Thesis:
Evaluated SharePlan™ (RaySearch Laboratories AB)
Paper 1
Paper 2
Paper 3
Paper 4
Doctoral Dissertation
Optimising the clinical use of tomotherapy
2009
Beginning my doctoral studies
Paper 5
What's unique?
New concept:
"fallback planning"

What's unique?
New concept:
"fallback planning"
What's unique?
Clinical grading analysis (CGA):
New method for comparing and evaluating plan quality

What's unique?
Correlated measurable biological side effects to the dose bath

Accepted for publication in
"Radiotherapy and Oncology"
What's unique?
The methods used in Papers 1-5 are comprehensively presented and explained!
The work is put into a greater context!

Is about to be defended!
Conclusions
Conclusions
Conclusions
Evaluated plan quality and deliverability of new delivery techniques for fallback planning
Conclusions
Aims
Conclusions
What's unique?
Evaluate plan quality and deliverability of currently available fallback TPS
(Papers 1, 2, and 5)
Develop a new treatment planning comparison method based on clinical judgements
(Papers 3, and 5)
Investigate the effect of the dose bath on clinically observed haematological toxicity (Paper 4)
Verified that generated treatment plans were deliverable with sufficient accuracy
Validated fallback planning in SharePlan™
Investigation of plan quality require a separate study
Generated treatment plans were comparable in quality to plans created "manually" in our clinical TPS
Plan quality improved with the use of more treatment fields
10-19 fields minimised the number of segments needed in a IMRT treatment plan
Aims
Evaluate plan quality and deliverability of currently available fallback TPS
Develop a new treatment planning comparison method based on clinical judgements

Investigate the effect of the dose bath on clinically observed haematological toxicity
CGA is presented as a useful method for comparing radiotherapy treatment plans
Suitable for introducing and evaluating new radiotherapy treatment techniques in a clinical setting
It facilitates a more optimal use of a clinic's advanced treatment resources
The severity of haematological toxicity correlated with the fraction of red bone marrow or body that was exposed to low dose
i.e. the dose bath
Generated VMAT treatment plans were of high quality and deliverability
Comparable to plans created "manually" in our clinical TPS
CGA results indicated that the objective value is useful for choosing between fallback delivery techniques
New type of treatment planning system:
It can only create IMRT plans from a reference tomotherapy plan

New methods required!
Used Pareto fronts to evaluate treatment plan quality
Full transcript