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Penicillin G

Chemistry
by

Sophie Woods

on 1 July 2013

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Transcript of Penicillin G

Penicillin G

Penicillin G is an antibiotic that treats bacterial infection.
It does not treat viral infections such as the common cold. Penicillin G is also a natural antibiotic and was one of the first antibiotics in clinical use. Penicillins may be used to treat infections such as urinary tract infections, septicemia, meningitis, intra-abdominal infection, gonorrhea, syphilis, pneumonia, respiratory infections, ear, nose and throat infections, skin and soft tissue infections. It is also effective against gram-positive strains of streptococci, staphylococci, and some gram-negative bacteria such as meningococcus. Penicillins prevent bacteria from using a substance that is necessary for the maintenance of the bacteria's outer cell wall. Unable to use this substance for cell wall maintenance, the bacteria swell, rupture, assume unusual shapes, and finally die. Penicillin G works best on an empty stomach.
Lewis Structure
Line Angle Structure
Model
Shapes
Functional Groups
Societal Impacts
History
References
Overview
Trigonal Planar
Trigonal Pyramidal
V-Bent
Tetrahedral
benzene
amide
alkane
carboxylic acid
Side Effects, Issues and Positive Attributes
Possible side effects are allergic reactions,severe agitation,anxiety, nerve damage, inflamation of the colon and unusual bleeding. Common side affects are diarrhea and pain. Penicillin G can only be injected, so if someone has a fear of needles or shots, it would be better for them to take Penicillin V which is taken orally. Some positive attributes of Penicillin G are it is a bactericidal against sensitive strains, it is relatively non-toxic, had excellent tissue penetration and is not very expensive.
benzene
amide
alkane
carboxylic acid
McKenna, Mackenzie, Sophie

- Originally noticed by Ernest Duchesne in 1896
- Rediscovered by Alexander Flemming in 1928
o Staphylococcus
o Observing mold
o Recreating as an experiment
o Alexander realized the significance of his discovery
- Hodkins used x-rays to find the structural layouts of molecules
o Her discovery led to the discovery of many other antibiotics
- Dr. Florey proceeded with research with his colleagues at Oxford University
o Research came to a halt when the war with Germany began
o Had to turn to the U.S. for help
o Peoria Lab
o Came up with a method of mass production of fungi
o Flew to the U.S. with Penicillin to start clinical trial
- Increased production of Penicillin
o Most effective antibiotic to date
o Prices dropped dramatically
o Andrew J Moyer patented his method for mass production
Penicillin G was very important during World War II. World War II was the first war in which Penicillin was used to stop infections. Penicillin is also known to have saved lives of many people outside of the war.
FUN FACTS
Penicillin was once called the miracle drug
Army pilots sent back soil samples from all over the world to be tested for molds
Laboratory staff members in Peoria, Illinois also kept an eye out for promising molds while grocery shopping or cleaning out their refrigerators.
Today, in the United States, deaths by infectious bacterial diseases are only one-twentieth of what they were in 1900
http://herbarium.usu.edu/fungi/funfacts/penicillin.htm
http://ezinearticles.com/?Penicillin-Antibiotics-Classification---Uses-and-Side-Effects&id=401820
google.com/images
http://www.pbs.org/wgbh/aso/databank/entries/dm28pe.html
http://www.botany.hawaii.edu/faculty/wong/bot135/lect21b.htm
CNN
Youtube-ANTM
www.wikipedia.com
Full transcript