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Ovarian Cancer Prezi

Ovarian Cancer
by

Fernanda Castro

on 19 February 2013

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Transcript of Ovarian Cancer Prezi

varian Cancer Ovaries -Part of female reproductive system.
-Produces and stores eggs.
-Produces hormones.
-3 types of cells in an ovary.
1. Epithelial cells.
2. Germ cells.
3. Stromal cells. Causes/Risk Factors -Specific cause is unknown.
-Risk Factors
-History of Breast Cancer.
- Not being pregnant.
- Women 55+.
-Taking estrogen replacement.
-Pregnancy/birth control reduce the risk.
-Defect on tumor suppressor genes
BRCA1 and BRCA2. Effects -Bloating
-Swollen belly
-Abnormal menstrual
symptoms
-Digestive disorders
-Excessive hair
growth
-Frequent urination Diagnosis -Pelvic Exam
-Ultrasound
-CA125 Blood test
-Lower Gastrointestinal
Series
-CAT Scan
-Biopsy Treatments 3 Main Treatments
Surgery, Chemotherapy,
Radiation Cell Division -Cells asexually reproduce and divide through mitosis, a part of the cell cycle.
-DNA must duplicate and distribute into daughter cells properly.
-Cell cycle is regulated by internal and external regulators. -"Stop" or "go" signals that regulate the cell cycle malfunction.
-Mutations in cell cycle-regulating genes like tumor suppressors and proto-oncogenes.
-Ovarian Cancer: Defect in the tumor suppressor genes BRCA1 and BRCA2.
-Requires a build up of damage to cell cycle-regulating genes. Cancer Cell Defects Molecular Genetics -Many genes control and regulate cell growth and division
-Cell Cycle Checkpoints: Allow genes to check for mistakes and stops cycle if something is wrong.
-Apoptosis happens when irreparable
DNA errors occur.
-Proteins carry out the work of genes. Types of Chemotherapy How do Mutations Happen? -Restricts DNA Replication
1. Alkalyting agents bind to the DNA in the cell to prevent it from dividing.
2. Antimetabolites replace the nutrients required for DNA reproduction with inactive substances.
3. Antitumor antibiotics prevent uncoiling and interferes with DNA structure.
-Others
1. Hormonal drugs suppress hormone processes.
2. Plant alkaloids interferes with the internal structure of the cell. Chemotherapy Drug: Taxol (Paclitaxel) -Type: Plant Alkaloid
How does it halt cell division?
-Interferes with the normal function of microtubule breakdown.
-Binds and locks tublin in place.
-Destroys the cell's ability to use its cytoskeleton in a flexible manner.
-Shortening and lengthening of microtubules is necessary for the transport of cellular components.
-Prevents cytoskeleton from restructuring. by: Carmen Yang & Fernanda Castro Normal Cell Division vs.
Cancer Cell Division -Errors in DNA duplication during interphase of mitosis.
-Environmental factors; radiation or chemicals that destroy DNA. -Requires open tumor surgery.
-Tumor will be coated with a specific type of glycoprotein to act as a cellular receptor, which the virus will target.
-Virus will be injected into the coated tumor, killing the cells. Cancer Treatment: Open Tumor Viral Injection Glycocell Cancer Procedure SAFE!!! FAST!!! EFFECTIVE!! NO LIFESTYLE CHANGE NECESSARY!! Cancer Stories Fernanda's family:

-Grandma, Ovarian cancer, died at 67.

-Great aunt, Ovarian cancer, died at 47.

-Grandma, Leukemia, died at 37.

-Step-Grandma, Breast Cancer, living. Stages of Ovarian Cancer -Stage 1: Cancer cells found in one or both ovaries, or in ascites.
-Stage 2: Cells spread from ovaries to the fallopian tubes, uterus and other pelvic tissues.
-Stage 3: Cells spread to tissues outside of the pelvis, lymph nodes, and may be found on the liver.
-Stage 4: Cells spread outside of abdomen tissues to the inside of the liver, lungs, or other organs. Bibliography: 1. "How Paclitaxel Works." How Paclitaxel Works. N.p., n.d. Web. 18 Feb. 2013.
2. "OVARIAN CANCER: Diagnosis and Treatment." OVARIAN CANCER: Diagnosis and Treatment. N.p., n.d. Web. 18 Feb. 2013.
3. "Facts about OVARIAN CANCER." Facts about OVARIAN CANCER. N.p., n.d. Web. 18 Feb. 2013.
4. "ATTENTION: THIS IS AN ARCHIVAL WEB SITE." Tumor Suppressor Genes: Guardians of Our Cells. N.p., n.d. Web. 18 Feb. 2013.
5. "Ovarian Cancer Risk Factors." Centers for Disease Control and Prevention. Centers for Disease Control and Prevention, 02 Sept. 2010. Web. 18 Feb. 2013.
6. "Introduction to the Viruses." Introduction to the Viruses. N.p., n.d. Web. 18 Feb. 2013.
7. "Viral Life Cycles in Cells." Viral Life Cycles in Cells. N.p., n.d. Web. 18 Feb. 2013.
8. "Gene Mutations That Can Lead to Cancer." Gene Mutations That Can Lead to Cancer. N.p., n.d. Web. 18 Feb. 2013.
9. "The Causes of Mutations." The Causes of Mutations. N.p., n.d. Web. 18 Feb. 2013.
10. "Ovarian Cancer." Centers for Disease Control and Prevention. Centers for Disease Control and Prevention, 30 May 2012. Web. 18 Feb. 2013.
11. "Swollen Lymph Nodes: Causes, Symptoms, and Treatment." WebMD. WebMD, n.d. Web. 18 Feb. 2013. 12. "How Do Genes Control the Growth and Division of Cells?" - Genetics Home Reference. N.p., n.d. Web. 18 Feb. 2013.
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