Loading presentation...

Present Remotely

Send the link below via email or IM

Copy

Present to your audience

Start remote presentation

  • Invited audience members will follow you as you navigate and present
  • People invited to a presentation do not need a Prezi account
  • This link expires 10 minutes after you close the presentation
  • A maximum of 30 users can follow your presentation
  • Learn more about this feature in our knowledge base article

Do you really want to delete this prezi?

Neither you, nor the coeditors you shared it with will be able to recover it again.

DeleteCancel

Make your likes visible on Facebook?

Connect your Facebook account to Prezi and let your likes appear on your timeline.
You can change this under Settings & Account at any time.

No, thanks

Hypersplenism

No description
by

razan alsini

on 11 October 2015

Comments (0)

Please log in to add your comment.

Report abuse

Transcript of Hypersplenism

• Identify the normal function of spleen

1- the
major
role of the spleen is to
filter the blood

2- the spleen
develops
and
produces mature immune cells
that are capable of identifying and dystroying pathogens

white pulp (B and T cells)

3- store the
RBCs
and
platelets

In the case of extreme bleeding occurs RBCs , platelets and macrophages released from the spleen .

Hypersplenism
Is an overactive spleen which causes the spleen to rapidly and prematurely destroy blood cells.
Outcomes:
Hypersplenism can be caused by:

• In secondary hypersplenism:
The underlying disease must be treated to prevent further sequestration or destruction of blood cell, and possible spleen enlargement.

A number of complication may occur when hypersplenism is left untreated they include

1-Pre-hepatic jaundice
2-Anemia
3-Pancytopenia
4-Neutropenia
5-Thrombocytopenia
6-Immune deficiency
7- Infection
8-Ruptured spleen
9-Bleeding

Hypersplenism

Define hypersplenism
• Causes of hypersplenism
• Clinical features of hypersplenism
• Criteria for a diagnosis of hypersplenism
• Differences between hypersplenism and other causes of pancytopenia
•Complications of hypersplenism
• Management for patient of Hypersplenism


Sunday
Spleen
Definition
Function
causes of hypersplenism
Diagnostic criteria
5
1
2
3
4
clinical
features of
hypersplenism

Lymphoma
Malaria
Tuberculosis
Various connective tissue and inflammatory diseases

A/The heamatological symptoms :
1- Symptoms related to thrombocytopenia are common , such as , bruising and epistaxis .

2- Symptoms related to anemia are fatigue , weakness and pallor .

3-Leucopenia leads to recurrent infection and oral ulcerations .

complications of
References
S
u
m
m
a
r
y
Supervised by:
Thank You

hypersplenism
7
Differences between hypersplenism and other causes of pancytopenia

Pancytopenia
6
Management for patient of Hypersplenism
• In severe cases:
The spleen must be removed (splenectomy) which will correct the effects of low blood cell concentration in the blood.

3. Pozo AL, Godfrey EM, Bowles KM; Splenomegaly: investigation, diagnosis and management. Blood Rev. 2009 May;23(3):105-11. Epub 2008 Dec 4.
1.Medscape
2.hypersplenism review article , ERWA ELMAKKI.
4.American journal of clinical pathology
5.http://emedicine.medscape.com/article/206208-overview
Dr.Omaima Ezzo

Dr.Fatima Safi Aldin
Done by:
Razan Alsini
Marwah Turkistani
Anhar AlQurashi
Hadeel Alsalmi
Halah AlOtibi
Atheer Altalhi
Shams Aldosari
Hadeel Ashour
Taghreed Esmael
Hypersplenism


The spleen destroys large numbers of blood cells (sequestration)

Aplastic anemia

bone marrow, and the blood stem cells that reside there, are damaged.

Lymphoma

Hemophagocytic Syndrome Associated with Hodgkin's Lymphoma

Following the removal of the spleen, individuals
often develop a fatal infection that is called
Overwhelming Post-Splenectomy Infection (OPSI)

It is characterized by either meningitis or sepsis and it is caused by the following encapsulated organisms:

S
treptococcus pneumoniae (pneumococcus
)


H
aemophilus influenzae type b (Hib)

N
eisseria meningitidis (meningococcus)


E
scherichia coli


S
almonella typhi

K
lebsiella pneumoniae


G
roup
B s
treptococcus (GBS)

A popular mnemonic to remember most of the encapsulated bacteria is the
SHiNE SKiS bacteria

It is generally recommended that people with asplenia are vaccinated against:


N
eisseria meningitidis

H
aemophilus influenzae

S
treptococcus pneumoniae

These vaccines can be remembered with the mnemonic:
SHiN
symptoms of anemia
infection and bleeding
infection
bleeding
frequent infection
hemorrhage
8
Complication of treatment
The pharmacological TTT depends on the cause of hyperspleism which include immune depressant and chemotherapy with their side effects.
Complication of spleneoctomy:
• Infections

• Thrombocytosis

And may develop of DM

Primary hypersplenism:
Idiopathic


Secondary hypersplenism :
Cirrhosis

B/The most common symptoms of splenomegaly :
1- Unable to eat a large meal.


2- Feeling discomfort, fullness, or pain on the upper left side of the abdomen this pain may spread to left

shoulder
.
3- severe pain when taking a deep breath .
1. Blood tests
such as a complete blood count to check the number of red blood cells, white blood cells and platelets in your system
2. Ultrasound or computerized tomography (CT) scan
to help determine the size of your spleen and whether it's crowding other organs
3. Magnetic resonance imagining (MRI)
to trace blood flow through the spleen
4.Bone marrow aspiration
can help to identify many of the causes of hypersplenism, such as leukemia, lymphoma, and metastatic cancer
Full transcript