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VITAMIN D, BEYOND BONE

By - Pooja Parekh , Zoya Patni,Sameer Bengali,Pooja Patel,Gurjyot Marwah,Shrunjal Shah,Chitrangada singh,Sheena Ali,Sanjana Kapoor.
by

Pooja Parekh

on 30 August 2012

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Transcript of VITAMIN D, BEYOND BONE

VITAMIN D Thank you for your attention! HOW? CNS DIABETES RS CANCER CVS WHERE? SKIN D FACTOR BY, FINAL YEAR STUDENTS OF PADMASHREE DR. D.Y.PATIL MEDICAL COLLEGE NOW? FACT: India get ATLEAST 9 months of good sunlight.

Q: Why are a significant population still at risk for Vitamin D deficiency?



Active form of vit D, CALCITRIOL benefits:
Adjusts cell growth and maturation
Regulates immune system
Topical calcitriol analogues e.g CALCIPOTRIENE/CALCIPOTRIOL, CALCITRIOL, TACALCITOL used, applied 2x daily in monotherapy (without corticosteroids) Vitamin D has been used to treat psoriasis in the topical form with great success. Prevents premature aging Prevents damage to skin structure Protective against skin cancer Prevention against skin infections (cc) image by anemoneprojectors on Flickr REFERENCES www.vitamindcouncil.org/health-conditions

www.solar-facts-and-advice.com/benefits-of-vitamin-D

www.naturalnews.com

www.vitamindwiki.com

www.naturalnews.com/vitamin_D_deficiency

Journal of Allergy and Clinical Immunology Volume 127, Issue 5, May 2011

www.youtube.com/watch?v=onSPZ0aBUKM&feature which? what was discovered? northern areas recieve less sunlight than southern areas
rates of colon and breast cancer was greater in the NORTH than SOUTH Vit D receptors activated
turning GENES on and off PREVENTS onset of cancer
cells adapt to new organ
APOPTOSIS increases CALCIUM
absorption from intestines increase in ACTIVE Vit D
from intake
increased sun exposure Prevents DYSPLASIA
Restricts ANGIOGENESIS
Reduces METASTASIS How?

Rates of colon cancer drop rapidly when levels of vitamin D are increased by 10ng/ml - 30ng/ml Research & Results multiple prospective and retrospective studies conducted BREAST CANCER Vitamin D blood levels greater than 40 ng/mL (100 nmol/L) reduce the risk of breast cancer by approximately 30%. Results meta graph indicating decrease in breast cancer with increasing concentrations of serum Vitamin D Conclusion Preventive and therapeutic use of Vitamin D being researched
vitamin D supplementation increases the post cancer mortality by 20 years
increase in Vitamin D levels prevent reccurrence of breast cancer Vitamin D deficiency indicated in:

Type I diabetes
- autoimmune destruction
of beta cells
- younger onset, thin, prone to ketosis

Type II diabetes
- insulin resistence
- 90% incidence,familial,older onset, obese How vitamin D affects Type I Diabetes: Evidence Ethnic Some evidence for north-south gradient
exceptions (e.g. Sardinia) Evidence for seasonal variation by time of birth in diabetic cases or according to season of the onset of the disease Birth cohort study pregnant women and infants administered vitamin D in north Finland in 1966
total number of 12058 participants in study
tested for Type I diabetes regularly till 1997
80% reduction in the risk if t had recieved at least some vitamin D
further 80% decrease among those who had received supplementation regularly if the dose had been at least the 2000 IU recommended at the time. Risk of Type II Diabetes reduces with Vitamin D CURRENT DRI RECOMMENDATIONS FOR VIT D39:
[By the Food and Nutrition Board at the Institute of Medicine]

Infants
• 0–6 months:- AI: 400 IU (10 µg/day)
• 7–12 months:- AI: 400 IU (5 µg/day)
Children
• 1– 3 years:- 600 IU (15 µg/day)
• 4–8 years:- 600 IU (15 µg/day)
Older Children and Adults
• 9–70 years:- 600 IU (15 µg/day)
• Adults > 70 years:- 800 IU (20 µg/day)
Pregnant and Lactating women
• Pregnancy and lactation:- 600 IU (15 µg/day) risk by 33% Cardiovascular Risk Factors Vitamin D deficiency activation of RAS Increase in
inflammatory
cytokines malfunction of
Calcium channels Hypertension Left Ventricular
hypertrophy Heart Failure Incidence The Framingham Heart Study noted that
Levels of vitamin D <18 ng/mL are associated with a 40% increase in cardiovascular events
Autism

Multiple Sclerosis

Parkinsons Disease How Does Vitamin D provide protection? Multiple Sclerosis Dementia Vitamin D may reduce the risk of dementia, especially Alzheimer’s disease. Autism Incidence:
autistic children generally have winter birthdays. MOA
reduces toxin induced dopaminergic cell death COLORECTAL CANCER PANCREATIC CANCER CNS Mental Health & Learning Disorders Neurological Conditions Depression


Dementia Protection
According to an Australian study a 7% reduction in risk of developing MS for each 4 ng/mL (10 nmol/L) increase in vitamin D levels in the blood BREAST CANCER PROSTATE CANCER Vit D acts on:
Beta defensin 2 gene directly, which encodes an anti-microbial peptide
NOD 2 gene, that alerts cells to the presence of invading microbes ASTHMA Vitamin D INHIBITS proinflammatory cytokine release by macrophages. Its ability to UP-REGULATE the expression of anti-microbial peptides is relevant, as these peptides can also exhibit ANTI-VIRAL activity. PREVELANCE AND SIGNIFICANE OF LOW 25(OD) IN NORMAL SUBJECTS IN DEHLI 4 groups of subjects were recruited based on different characteristics relevant to bone mineral homeostasis:
Physcians and nurses (SUMMER AND WINTER)
Soldiers (WINTER)
Pregnant women and their newborns (SUMMER)
Depigmented subjects (WINTER) TB CARDIOVASCULAR DISEASE IN ASSOCIATION WITH CHRONIC RENAL DISEASE ACVITITY BY THESE TWO GENES ENHANCES IMMUNITY GIT Q: What is this? IBDs like Crohns Disease
and Ulcerative Colitis seasonal variation immune mediated mmol 25(OH)D STATUS OF NORMAL INDIANS IN SUMMER Supplementation with oral vitamin D dramatically induces cathelicidin production in the skin of patients with atopic dermatitis. It also slightly elevates its production in normal skin in this study. ACKNOWLEDGE
Dr Archana Bhate
Dr. Mahesh Epilepsy Anti epileptic drugs decreased bone density increased risk of fractures Prevention
Supplementation of Vitamin D to maintain serum levels of 30-40ng/ml (75-100nmol/l) Healthy pancreatic Islet cells Unhealthy pancreatic Islet cells Type 1 diabetes is an autoimmune disease, where the insulin secreting beta cells in the pancreas are destroyed by the body’s own overaggressive immune defence system COLON CANCER TB Sanatoriums have traditionally been located in sunny places TB PATIENTS HAVE LOWER 25(OH)D LEVELS COMPARED TO CONTROL SUBJECTS HIGHER SPUTUM CONVERSION
IMPROVED RADIOLOGICAL FINDINGS THERE ARE OVER 10 CRORE INDIANS SUFFERING FROM ASTHMA Vitamin D < 30 ng/ml 30%-50% increased risk of Cancer OVARIAN CANCER Colorectal cancer 26 percent less likely for every 10 ng/ml of vitamin D 26% Prophylatic efficacy
2000-5000 IU of Vit D Conclusion Therapeutic efficacy
>8000 IU of Vit D Neuroprotective
Associated with better memory and information processing Parkinsons Disease American study conducted in 2008 found patients with PD to have 55% less Vitamin D than normal individuals. MOA
increases Nerve growth Factor (NGF) protecting against dementia Alzheimers MOA
decrease number of amyloid plaques - a hallmark of Alzheimer’ Vitamin D <10ng/ml = 2 x risk of alzheimers MOA
reduces cytokine induced inflammation in the brain during MS Dr. John Canell Vit D deficiency has been detected as a risk factor for many cardiac disease like... HYPERTENSION LVH CONGESTIVE CARDIAC FAILURE PATHOGENESIS DEFICIENCY: <20µg/L VITAMIN D AND LIVER DISEASES low vitamin D = raised free fatty acid


non-alcoholic fatty liver disease (NAFLD) V S FOR THOSE OF YOU LIVING AT THE POLES, AND FOR THE REST OF US, WHO DON'T WANT A TAN! Prevents ACNE Vitamin D Strengthens immune system UVB light reduces the risk of acne Kills
bacteria INSUFFICIENCY: 20-30 µg/mL TOXICITY >1250µg/day anaemia
nausea, vomiting
polyuria, polydypsia
weakness
nervousness
pruritis
renal failure
urinary casts
metastatic calcification SYMPTOMS ? Vit D as immunomodulator
FIBROBLAST supression
COLLAGEN supression increases INTERFERON efficacy in HEPATITIS C
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